VISSEQ Data Explorer
About
Lamin A
PTEN iPSC
PTEN Neurons
Data download
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Selected variants
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Use the search bar and the add/remove buttons to select any variants or groups of variants you are interested in. They will show up highlighted in the UMAP and heatmap plots below. When you have made your selections, click the "Update plots" button to reload the page
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Synonymous
Frameshift
ClinVar: P/LP
Anderson Punctate
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Cluster 5
Cluster 6
Cluster 7
Cluster 8
Cluster 9
Cluster 10
Selected features
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Use the search bar and the add/remove buttons to select any cellular features you are interested in. By clicking on individual features they can be selected and removed using the remove button.
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NucleiExpanded Intensity MeanIntensity mEGFP-LaminA
NuclearBoundary Intensity MeanIntensity mEGFP-LaminA
NucleiExpanded Granularity 1 mEGFP-LaminA
Nuclei AreaShape FormFactor
Variant UMAP
K260Q
E264N
E214V
Q184F
Q258E
E236K
V191T
N195Y
M187N
F237W
L248Y
I210N
K180A
E178S
Q184V
N273T
Q198D
L271D
A244T
E194G
I210F
E217V
N273H
A242P
R196C
Q251R
K261I
K208Y
D185P
L241E
Y259fs
R189E
L183H
A179A
Y211N
T224P
L263W
E228D
Q258P
K260fs
T224F
A242G
V227F
A250M
L215M
I210H
Y259T
E213I
M200P
D254C
E257D
T199W
L226A
I229H
E217P
E194R
K233S
R190S
G232T
A250I
L215H
K201E
K233A
E203R
L263C
Q207A
M187S
N209P
K261K
L183C
Y267A
M187K
E213H
D185W
S268L
R196A
Q246C
R189T
R235T
R220Q
K270P
E238Y
D185E
L241V
K233I
E178H
L183N
K270S
G232N
R189A
Q207S
Q207F
A269M
L197C
R225Q
E213C
V191K
D205R
T218N
T266W
L197Y
R240I
L248H
L271T
Y259W
H252S
E217L
R221F
V227V
I210W
A193D
Q258W
E253V
N209fs
E253S
D185R
K265H
E236P
Y259A
L271S
S239W
Q246F
E213S
S268W
A193W
A244A
Y259G
R190E
R216R
T218D
L271A
R221R
S239P
N209L
A179M
E264C
Q207P
E262I
G232S
K260C
S507fs
I210D
E178E
K201N
Q184fs
E223N
Q258M
R190G
K201D
Y211D
R196K
F237L
S212Q
V256R
D192A
E257N
Q234H
L241G
S212W
T218G
N195K
A193V
N231R
H252M
T266R
G232L
Q255S
F237A
K180D
R220P
Q198H
K270F
L271fs
E186E
E223fs
R235H
M187Y
D205M
G232A
A242N
L241W
E236R
K181D
F206T
V256Y
R235S
D254V
T224S
F237E
E228A
E223W
E238I
E253I
K208R
E223V
N273G
L226Q
L197W
T218F
Q246N
E264E
D243Y
R240G
F237N
H252K
L226L
Q182P
L215L
Q234M
E202T
D230E
N195S
E228Y
N209D
Y267K
R189I
D254S
E217G
L188H
R196G
E262E
F237H
R189L
K180P
A242Q
D272E
K219S
V256H
E253A
R221W
S212L
Q182F
K201F
L197T
L215W
F206N
Q184W
K180R
L226Y
Y259M
A244Q
R225C
E264P
S239L
V191V
D205I
E228F
H252P
Q184T
A242W
E257Y
E228I
R221A
E264V
K180M
F237K
K261W
L226T
D205C
L183K
N231P
L188L
V227A
E186V
L204W
R235P
Y267H
E236C
E223I
K233T
F237I
Y259N
L197Q
Q182L
E202A
K261Q
Q251D
L248V
A250E
V227H
N231I
K260V
A193E
A179T
D230F
K270T
D185T
R235Q
L188E
D272D
D243N
E202P
R235G
T266S
E203P
D254Q
E194K
E228R
R220H
N195M
K233M
D243P
A250F
M187Q
E247P
E264M
V256E
L204I
A242C
E238Q
K201K
S239T
G232W
Q198W
T218H
E247T
T199R
E262F
Q251N
L241K
G232Y
M200W
R189F
L183R
E223L
R221I
A244K
A193N
K201C
K261A
E236N
H252A
Q207T
K260W
E213M
K201T
S268I
D272T
L188W
G232G
Q207W
L204K
S239K
K208K
R235C
Q246P
Y259E
K270E
M187E
R225D
R189P
K219I
I229Y
L197G
R235Y
E223F
K219A
E213Y
Q234S
K181T
K233L
D243G
L183F
L215I
A242T
D243I
K265I
K180L
R190D
L188Q
D230T
H222E
K260H
I210G
K233F
K270G
E194E
Q184A
M200fs
E238fs
L271V
E236L
Y267Q
R240H
E203D
E214N
G232M
A250H
E217D
R196E
L245M
T266Q
L215G
E186W
D192I
K260S
K181F
L241M
Q251Y
F237fs
A242H
K219K
A250V
Y267S
T199T
L271L
L226E
N273W
E257F
R225G
M187L
E264I
Q255W
D192N
K233R
E253L
R220F
F237V
N209R
K181C
D192S
V227Q
E214Y
E257C
A269D
E247D
Q251H
E257H
D230I
D205L
E236G
E186N
E217Y
R196S
E194S
Q258A
D192W
K219H
S239R
M187H
Q246L
V256T
R216T
S212D
L263E
K208L
E223T
K201H
Q198V
Q182S
Q234W
E228T
M187P
E202K
K181E
Q184N
N195W
Q207D
L245H
D254T
Q234K
M200E
E264Y
E202fs
R190C
Q258Y
S212K
M200C
A244R
T266G
E213fs
A242E
T218Y
E217S
Q198I
Q258N
L215R
E178V
E178P
A250W
R216Q
Q251P
L241P
E257E
F237S
S239N
R220W
E238E
K270L
K219F
F206W
M200A
F206M
E262M
E217K
I210L
K260G
V191G
L204D
E213W
D243Q
K180W
E186S
Q251V
Q207L
Y211V
A242V
E217T
R190W
L215S
Q255G
M200G
V256Q
R220T
N195D
A244F
K219P
M187A
R189R
D254I
E217H
Q234F
S268Y
F206A
R196M
E194C
A269F
K261P
Y267Y
E213T
E262T
K201L
R225W
L188P
N209A
D230H
F206S
S268R
S212C
R216G
Y267I
E203G
K180Q
L245W
V256F
N273S
Y259S
E223S
A269A
E257S
Q207M
Q255A
N273E
A193Y
E262C
R220K
D205H
K260A
E238H
A179I
E217Q
R225Y
L241H
D243S
M187R
R190F
F206Q
L245Y
Q184E
A250N
D243T
E213E
N209F
K265N
Q182D
I210R
L183M
E213R
L263M
A244W
T224V
L263D
N195V
E213A
S268E
N231W
E217W
Q246H
I210S
N195A
D272H
E186F
N231E
R216M
L226V
D272W
Q255I
H252L
Q255V
D192P
Q207I
K265P
L197I
A179N
E202I
E223C
A179Q
I229A
R196Q
R196I
E253Y
E264A
K219E
K181Q
F237Y
D192K
R225A
Y259V
Q184S
D230K
L188N
E264S
D230Y
T218P
E214S
F206C
R190Q
Q258G
L248M
Q251T
E228L
V191Y
Q182E
D230fs
F206V
L263L
D192Y
A244D
M187C
Q246D
K260T
L197E
Q198E
D272R
I210P
L271R
D192H
R221H
L245S
A250G
K233W
R216W
L245P
L183E
T224D
K208H
E264F
K260R
Q207V
A269H
D185G
V191F
R240S
N195T
K180H
M187F
E186P
R220V
Q182G
R221D
K180G
K219N
Q207H
R235D
E202Q
N231C
T199G
E203N
Y259L
R221Q
N195G
T218V
Y259C
M187V
L245F
D243K
L263Q
A179F
A250D
S268P
T224H
L215E
E178G
D205Q
L245V
D272G
K219D
G232P
D272K
K208S
E264H
E253D
K233Y
K181G
K208T
A242D
L183I
R190N
K201R
L241C
M187D
N195H
H222M
D243C
Q234L
E214Q
H222V
Q182K
K265S
V227K
R220D
L263S
E253P
A269G
K180I
T224Q
L188A
L263V
L226fs
I229S
L263A
A242A
Q255N
L204M
K208fs
K181N
D185K
S268C
S268S
A250K
K261M
L183L
N231M
Q184L
L263G
E253C
L248F
E194L
E186T
Q246V
E257T
Q246W
E238C
L204V
Q255H
L215C
V191I
E238S
Q207Q
Y211Q
V256C
E236V
Q184D
N231Q
E203K
S268F
E213F
S212R
K180C
Y211M
S239Q
E178L
E262R
Q258T
R225F
S212P
A193M
V256D
L241I
D272I
Y211G
R190H
L215F
A179W
E264D
A269S
A193G
T218I
M200H
L204S
K261H
L271M
D185I
R240A
E253W
D230V
H222D
K261L
K180E
T218K
V191fs
Q198L
A269L
E203Q
N231H
A242F
Q255M
S212F
D243R
A250S
D185C
R225P
E223A
V191A
V227G
L248D
Y211A
R216K
E228G
A242K
E194I
T218E
D205K
Q182H
V227D
K181M
R240E
F206H
D192G
L204A
H222T
N231L
A193C
Y259D
L245L
R221N
L204L
L241Y
Q207G
K265R
H222L
S239D
T266V
L245C
Q198R
D254M
Q251E
L183G
K181H
Y267E
E247E
L226M
K233E
R220M
R235I
K233P
R240L
S239E
D272N
I229I
D192C
S239M
K261E
L204H
Q255T
Y211K
E228S
L188S
E178W
S239A
L188R
A193Q
S239V
Y259F
Y211T
E213D
K219L
R190V
A244S
Y267F
D230D
H252D
E202S
L204P
N231D
R190M
Q234V
E194W
D230C
R190K
K180K
E238T
L215V
Q234A
L245E
E186D
E194Q
I210Y
R235L
L271Q
K181V
L183S
Y259P
E257R
L263R
E202E
H252C
K260I
R190I
D192F
E238F
E186M
K181W
R189K
F206K
H252F
A193A
K219T
E257G
K260Y
E213K
R240D
L226N
K265L
E264G
D205A
L226C
L248K
H222S
R240V
N273M
N273Y
L197P
L226I
R225N
S268G
I229C
L188G
E202N
T224G
R189D
Q184K
K181S
E202D
M200Q
N195F
Q207R
H222P
G232K
D272A
L245G
A250Q
L263T
E214T
D254H
R189Y
E253E
Q184R
K219Q
D205P
L188C
L271C
T224L
E214L
I229R
T199Q
L188D
Y211F
I210A
K208W
Q246Q
T266P
G232Q
Q251K
K233H
D272V
Y267D
N231G
D230Q
V256V
D254L
K270N
E178N
Q234P
R240Y
E194N
I229L
F237C
Q251I
Y267R
E213L
A179D
T224E
M200D
F237G
L226K
G232H
L245R
K265V
L215Y
R220G
K233N
Y267L
V227S
R225I
K270I
Q255L
L197K
Q258H
H252G
E186G
R216N
L271K
L183W
R235A
T218C
K265W
R216L
L215K
S239H
K233Q
T218L
F206fs
F237T
D205G
R240P
R216E
E238L
T218M
D205F
L197M
F237R
N273D
D205W
M200I
E228H
A179S
D192R
D205Y
Q207N
L188K
E178R
N273R
E236I
E257K
E223M
A244I
N273I
A179H
E186I
Q258K
E223E
A193L
A179L
K208C
Q182Q
E178K
E264T
Q255Q
E238G
A179E
Q234E
R221S
L241T
L271P
G232R
N273P
A193H
D192M
F237F
E253T
E228P
D192D
Q182T
R189S
L263F
H222A
H222Y
Q234C
E178Q
V227E
G86fs
E253R
A244L
N209G
Y267C
Q255Y
E238N
Y211R
M200F
T199D
D205E
S239Y
K265C
V256I
A250P
A179G
E203V
L271H
E213N
A244Y
S212Y
S268D
E214R
S268Q
Y211I
E223Y
T224N
D205V
S268V
G13fs
A269C
V256M
R235R
V191E
N209H
H222R
K181I
E238A
K261F
A242L
Q234Y
D185F
M200T
E186R
Y267V
L248N
V256P
E214M
E214D
Q234fs
L245D
L248Q
L226R
K181fs
K265T
Q198K
E213V
A269E
R225K
R216Y
L215D
K260N
L226W
L263I
S212I
M200Y
R240K
E262Q
N231Y
K180F
S268K
Q251W
Q184M
R240C
E262K
R190T
D254F
H252W
N195R
D205N
L263H
R225R
T199A
E214G
L245K
V227M
E213P
D254E
T218A
D243F
D185A
V256W
K261S
L204Y
E257Q
D185D
A179R
Q251F
K201A
N273C
T218R
H222I
T224M
E214H
N273L
K265M
T218Q
L248L
Q234R
G232E
E253M
E238W
L263N
D205D
D185S
L215T
S239C
K260P
Q198M
D230L
E238P
A244E
L188F
Y267W
Y211H
Q207K
E236Q
E257I
E217C
D230W
Y267P
N209T
N195E
L197A
Y211S
Q182M
Q184Q
Q198G
V256K
L188I
T218S
V227R
Q255R
R189M
Q182N
T224R
R225V
D230A
T224A
Q184H
Q246E
L248I
V227N
L245T
G232I
H252R
K260E
R240R
E257V
E178C
V191S
L215N
A193T
I229P
H222C
E202W
E194Y
H222Q
Q184G
E203H
D272S
N273Q
F206P
D185L
Q182A
D205T
K270V
R216I
L197V
I210fs
Q251G
K265D
E228Q
E236E
E223Q
Q251A
Y267G
V191L
K261C
S239G
Y259R
G412fs
E186H
H252N
E178D
N273F
R221T
L245N
K181A
A179K
V256N
N209K
R235M
Q258C
N209W
E262A
H252Q
Q198S
L183P
L241Q
D272F
D185Q
E213G
V191P
R225E
E217M
R235W
E214A
I210E
A269Y
D230R
E194H
E186K
K261V
N273N
R220S
I229K
D230S
K219R
Q246Y
L226F
Y211W
R196W
T266M
E238R
I229T
H252Y
E186C
V256G
L215A
E228C
E194F
Q182C
A193I
R190Y
K181K
R221G
E217I
L241S
A242Y
R240T
A244P
E223D
V191R
L204N
D243M
G232C
D205S
V227T
R240N
L183T
E236T
Q246K
S212N
K201M
F206R
L204R
H252V
A269K
K180N
Q255K
R240W
R189W
R240Q
R221K
D272Q
Q246S
S268H
A179P
K260D
T266fs
G232V
Q234N
K261D
Q184C
L271F
E214P
Q258S
H252H
R216S
D254P
L215P
L263fs
A250L
K219Y
E194D
E264R
A250R
H252T
R220E
E236F
E264Q
Q198T
E194V
I210I
Q246R
T224fs
L183Q
K219G
D185M
A193R
E238D
A179C
K270Y
I210V
A244H
Q258V
K265E
H222H
T224I
E257A
D254Y
K208I
E264W
E214F
L197R
D272L
D254W
L226G
A244M
R220I
E186Y
D272P
Y267T
D254G
L271G
Q258D
K270R
V191N
Q234Q
K181R
A242M
L248W
R220Y
S212E
G232F
A244C
D243W
L197F
K260M
K270D
A250T
S268N
L204Q
E214K
I229Q
K261R
L197S
T224W
E202Y
K208G
A193F
A250C
A269I
K181Y
N231T
K208P
Y259H
H222F
T224Y
I229N
K180Y
D230M
V256fs
H222K
Q184I
S239I
R221P
K219C
K201S
E213Q
E253G
E223R
L197N
F237Q
L226P
K261G
E178A
F237M
Q184Y
E236Y
R196R
L271E
K265K
K233V
L271W
K180V
Y211Y
A269V
E186A
R225M
E236D
N273V
K233K
R190L
D272C
E262G
E217N
T10fs
M187I
E223P
N209E
K219M
T218W
Q255F
L188Y
R196N
Q198N
G232D
E253Q
E262N
R225L
D192V
K270K
L204G
D272M
K233C
E217A
D192T
Q182Y
V191W
D243L
V191C
L241R
V191Q
A250A
E203W
Q182R
Q182W
R190P
T218T
E262D
E214E
M187T
E178Y
V256S
L197D
Q258L
D254N
R221C
N231A
E202V
E202G
T199I
S239F
A244N
K181P
L183A
R240M
K219W
K233D
K261Y
L226S
N195N
K201P
V227L
Q234T
Y211P
K201V
E223H
E247Y
L241N
L226H
D254K
L241F
K208V
R220R
D243H
E262V
S212A
Q198Y
D243V
L241D
V227W
T224K
K233G
N209Q
Q182I
E228V
L183V
R221L
Y259Y
D185V
E262P
R189V
L183D
L197L
I229V
Q234D
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N273R
E236I
E257K
E223M
A244I
N273I
A179H
E186I
Q258K
E223E
A193L
A179L
K208C
Q182Q
E178K
E264T
Q255Q
E238G
A179E
Q234E
R221S
L241T
L271P
G232R
N273P
A193H
D192M
F237F
E253T
E228P
D192D
Q182T
R189S
L263F
H222A
H222Y
Q234C
E178Q
V227E
G86fs
E253R
A244L
N209G
Y267C
Q255Y
E238N
Y211R
M200F
T199D
D205E
S239Y
K265C
V256I
A250P
A179G
E203V
L271H
E213N
A244Y
S212Y
S268D
E214R
S268Q
Y211I
E223Y
T224N
D205V
S268V
G13fs
A269C
V256M
R235R
V191E
N209H
H222R
K181I
E238A
K261F
A242L
Q234Y
D185F
M200T
E186R
Y267V
L248N
V256P
E214M
E214D
Q234fs
L245D
L248Q
L226R
K181fs
K265T
Q198K
E213V
A269E
R225K
R216Y
L215D
K260N
L226W
L263I
S212I
M200Y
R240K
E262Q
N231Y
K180F
S268K
Q251W
Q184M
R240C
E262K
R190T
D254F
H252W
N195R
D205N
L263H
R225R
T199A
E214G
L245K
V227M
E213P
D254E
T218A
D243F
D185A
V256W
K261S
L204Y
E257Q
D185D
A179R
Q251F
K201A
N273C
T218R
H222I
T224M
E214H
N273L
K265M
T218Q
L248L
Q234R
G232E
E253M
E238W
L263N
D205D
D185S
L215T
S239C
K260P
Q198M
D230L
E238P
A244E
L188F
Y267W
Y211H
Q207K
E236Q
E257I
E217C
D230W
Y267P
N209T
N195E
L197A
Y211S
Q182M
Q184Q
Q198G
V256K
L188I
T218S
V227R
Q255R
R189M
Q182N
T224R
R225V
D230A
T224A
Q184H
Q246E
L248I
V227N
L245T
G232I
H252R
K260E
R240R
E257V
E178C
V191S
L215N
A193T
I229P
H222C
E202W
E194Y
H222Q
Q184G
E203H
D272S
N273Q
F206P
D185L
Q182A
D205T
K270V
R216I
L197V
I210fs
Q251G
K265D
E228Q
E236E
E223Q
Q251A
Y267G
V191L
K261C
S239G
Y259R
G412fs
E186H
H252N
E178D
N273F
R221T
L245N
K181A
A179K
V256N
N209K
R235M
Q258C
N209W
E262A
H252Q
Q198S
L183P
L241Q
D272F
D185Q
E213G
V191P
R225E
E217M
R235W
E214A
I210E
A269Y
D230R
E194H
E186K
K261V
N273N
R220S
I229K
D230S
K219R
Q246Y
L226F
Y211W
R196W
T266M
E238R
I229T
H252Y
E186C
V256G
L215A
E228C
E194F
Q182C
A193I
R190Y
K181K
R221G
E217I
L241S
A242Y
R240T
A244P
E223D
V191R
L204N
D243M
G232C
D205S
V227T
R240N
L183T
E236T
Q246K
S212N
K201M
F206R
L204R
H252V
A269K
K180N
Q255K
R240W
R189W
R240Q
R221K
D272Q
Q246S
S268H
A179P
K260D
T266fs
G232V
Q234N
K261D
Q184C
L271F
E214P
Q258S
H252H
R216S
D254P
L215P
L263fs
A250L
K219Y
E194D
E264R
A250R
H252T
R220E
E236F
E264Q
Q198T
E194V
I210I
Q246R
T224fs
L183Q
K219G
D185M
A193R
E238D
A179C
K270Y
I210V
A244H
Q258V
K265E
H222H
T224I
E257A
D254Y
K208I
E264W
E214F
L197R
D272L
D254W
L226G
A244M
R220I
E186Y
D272P
Y267T
D254G
L271G
Q258D
K270R
V191N
Q234Q
K181R
A242M
L248W
R220Y
S212E
G232F
A244C
D243W
L197F
K260M
K270D
A250T
S268N
L204Q
E214K
I229Q
K261R
L197S
T224W
E202Y
K208G
A193F
A250C
A269I
K181Y
N231T
K208P
Y259H
H222F
T224Y
I229N
K180Y
D230M
V256fs
H222K
Q184I
S239I
R221P
K219C
K201S
E213Q
E253G
E223R
L197N
F237Q
L226P
K261G
E178A
F237M
Q184Y
E236Y
R196R
L271E
K265K
K233V
L271W
K180V
Y211Y
A269V
E186A
R225M
E236D
N273V
K233K
R190L
D272C
E262G
E217N
T10fs
M187I
E223P
N209E
K219M
T218W
Q255F
L188Y
R196N
Q198N
G232D
E253Q
E262N
R225L
D192V
K270K
L204G
D272M
K233C
E217A
D192T
Q182Y
V191W
D243L
V191C
L241R
V191Q
A250A
E203W
Q182R
Q182W
R190P
T218T
E262D
E214E
M187T
E178Y
V256S
L197D
Q258L
D254N
R221C
N231A
E202V
E202G
T199I
S239F
A244N
K181P
L183A
R240M
K219W
K233D
K261Y
L226S
N195N
K201P
V227L
Q234T
Y211P
K201V
E223H
E247Y
L241N
L226H
D254K
L241F
K208V
R220R
D243H
E262V
S212A
Q198Y
D243V
L241D
V227W
T224K
K233G
N209Q
Q182I
E228V
L183V
R221L
Y259Y
D185V
E262P
R189V
L183D
L197L
I229V
Q234D
N231S
I210Q
T199V
E217R
L248R
D185N
K261N
V629fs
E214C
A269N
K417fs
I229E
Q258F
K180T
L271I
T199N
L188T
N231F
D243E
R235V
K201W
K265A
E257W
N273K
H252I
V227C
S268M
R216P
R196F
R221Y
F237P
A269Q
R235E
K180S
L245I
F206Y
E253F
T224T
L263K
R225S
N195L
L248S
Q207C
A193K
D230N
Y211L
R216C
E238V
L241A
N209Y
K270A
E238K
Q207Y
E257M
K219V
E194fs
E264K
D192L
H222W
E223K
A242S
L188M
F237D
Q255D
L226D
E247M
F206G
N209I
I229G
L263Y
E194T
E257L
H252E
Q198P
R235F
R225H
N209C
A269W
D272Y
E228E
E178I
E257P
R216D
R235K
L271N
R240F
S212S
Q258Q
V227I
Q255P
K181L
K201Y
E186Q
E223G
V191M
R216H
Q234I
D243D
D254D
A179V
R220L
I229M
E228M
L204E
Y259I
E262S
V227Y
L204F
R216V
Q198C
N195C
E253K
E178F
Y211C
K260L
E236W
S239S
D254R
M200V
F206I
L271Y
Q251M
Q255E
K261T
M187W
M200N
R221E
M200L
E194M
E202F
L215Q
E262W
Q246A
N231V
Q182V
N231K
Y211E
A244V
A250Y
D192E
E253H
E253N
H222G
K265F
H222N
D185Y
E236S
I210C
S212H
A242R
R216F
I229F
E217F
R216A
S268A
K265G
R220A
L188V
E236A
M200K
A193P
V191H
A179Y
K201Q
K270H
K260F
R221V
E236H
R190A
F206L
R220C
E203I
A242I
D230G
N231N
Q207E
L241L
Q234G
D230P
E228W
E178M
Q255C
E217E
D254A
R196V
A269T
-9
-6
-3
0
3
6
9
Color UMAP plot by:
None
NucleiExpanded Intensity MeanIntensity mEGFP-LaminA
NuclearBoundary Intensity MeanIntensity mEGFP-LaminA
NucleiExpanded Granularity 1 mEGFP-LaminA
Nuclei AreaShape FormFactor
Randomly selected cell images
Variant: Synonymous
Variant: Frameshift
Volcano plot: Frameshift
-log10(pvalue)
Cytoplasm RadialDistribution FracAtD DAPI 1of10
NucleiExpanded RadialDistribution RadialCV DAPI 9of10
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 5 02 256
NucleiExpanded Texture Contrast DAPI 20 03 256
Cytoplasm RadialDistribution FracAtD Ph+WGA 1of5
Cytoplasm Texture Variance mEGFP-LaminA 10 01 256
NuclearInterior Intensity StdIntensityEdge DAPI
Cytoplasm Texture InverseDifferenceMoment DAPI 10 02 256
NucleiExpanded Texture Variance DAPI 5 00 256
Cytoplasm Intensity IntegratedIntensity Mito
Cytoplasm Granularity 8 mEGFP-LaminA
NucleiExpanded Texture Contrast DAPI 5 00 256
AreaShape MeanRadius
NucleiExpanded Granularity 4 mEGFP-LaminA
NucleiExpanded Texture Variance DAPI 10 02 256
Cytoplasm RadialDistribution RadialCV Mito 1of5
NuclearInterior Intensity UpperQuartileIntensity mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac DAPI 5of10
Intensity MeanIntensityEdge DAPI
Cytoplasm RadialDistribution MeanFrac DAPI 3of10
NuclearInterior Intensity IntegratedIntensity mEGFP-LaminA
AreaShape ConvexArea
NucleiExpanded Granularity 4 DAPI
Cytoplasm RadialDistribution RadialCV Ph+WGA 4of5
NucleiExpanded Texture Contrast DAPI 5 02 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 20 03 256
Cytoplasm Intensity MADIntensity Ph+WGA
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 5 02 256
Cytoplasm Texture Variance mEGFP-LaminA 20 01 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 5 03 256
Cytoplasm Texture DifferenceEntropy DAPI 20 00 256
NucleiExpanded Correlation Manders mEGFP-LaminA DAPI
NucleiExpanded Texture DifferenceEntropy DAPI 10 00 256
Cytoplasm Texture SumAverage DAPI 5 03 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 10 03 256
NuclearBoundary Correlation RWC DAPI mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac Mito 3of5
NucleiExpanded Texture InfoMeas2 DAPI 20 00 256
NucleiExpanded Texture Correlation DAPI 10 02 256
NucleiExpanded RadialDistribution RadialCV DAPI 2of10
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 5 01 256
NucleiExpanded RadialDistribution RadialCV DAPI 6of10
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 10 03 256
Cytoplasm RadialDistribution FracAtD Ph+WGA 5of5
Cytoplasm Intensity MedianIntensity DAPI
NucleiExpanded RadialDistribution RadialCV DAPI 5of10
NuclearInterior Intensity MinIntensityEdge mEGFP-LaminA
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 20 00 256
Intensity MaxIntensity mEGFP-LaminA
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 20 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 10of10
NucleiExpanded Intensity StdIntensity mEGFP-LaminA
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 5 01 256
Cytoplasm Texture Entropy mEGFP-LaminA 10 00 256
NucleiExpanded Texture Variance DAPI 20 01 256
Cytoplasm Texture Entropy DAPI 20 02 256
NucleiExpanded Texture Entropy DAPI 5 01 256
NucleiExpanded Texture DifferenceEntropy DAPI 20 00 256
Cytoplasm RadialDistribution RadialCV Mito 4of5
Intensity MinIntensity DAPI
Cytoplasm Texture SumVariance DAPI 10 03 256
NucleiExpanded Texture SumEntropy DAPI 10 03 256
Cytoplasm Texture DifferenceEntropy DAPI 5 00 256
NucleiExpanded Texture SumVariance DAPI 10 02 256
AreaShape EquivalentDiameter
NucleiExpanded Texture Variance mEGFP-LaminA 5 03 256
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 7of10
NucleiExpanded Granularity 5 mEGFP-LaminA
Cytoplasm Texture Correlation mEGFP-LaminA 5 01 256
Cytoplasm Texture DifferenceVariance DAPI 20 00 256
NucleiExpanded Intensity MinIntensityEdge DAPI
Nuclei AreaShape Area
NuclearInterior Intensity UpperQuartileIntensity DAPI
NucleiExpanded Intensity IntegratedIntensity mEGFP-LaminA
Intensity MaxIntensityEdge mEGFP-LaminA
Cytoplasm Intensity MassDisplacement Mito
Cytoplasm Texture DifferenceVariance DAPI 10 03 256
NuclearBoundary Intensity MedianIntensity mEGFP-LaminA
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 5 01 256
Intensity LowerQuartileIntensity DAPI
Cytoplasm Intensity MeanIntensity DAPI
NucleiExpanded Texture Correlation DAPI 10 01 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 10 01 256
NucleiExpanded Granularity 12 DAPI
Cytoplasm RadialDistribution RadialCV Mito 5of5
Cytoplasm Texture DifferenceEntropy DAPI 5 02 256
Cytoplasm Texture InfoMeas2 DAPI 20 03 256
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 1of10
Cytoplasm Intensity MeanIntensityEdge DAPI
NucleiExpanded Texture InfoMeas2 DAPI 10 02 256
NuclearInterior Intensity IntegratedIntensityEdge DAPI
Cytoplasm Intensity StdIntensity mEGFP-LaminA
Intensity IntegratedIntensityEdge mEGFP-LaminA
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 20 03 256
NucleiExpanded Intensity MeanIntensity mEGFP-LaminA
Cytoplasm Texture SumEntropy DAPI 5 01 256
NucleiExpanded Texture SumVariance DAPI 5 02 256
Neighbors PercentTouching Adjacent
NuclearBoundary Intensity UpperQuartileIntensity mEGFP-LaminA
NucleiExpanded Texture SumAverage mEGFP-LaminA 20 01 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 10 02 256
NuclearBoundary Intensity MeanIntensity mEGFP-LaminA
NucleiExpanded Texture Entropy DAPI 10 00 256
NucleiExpanded Intensity UpperQuartileIntensity DAPI
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 7of10
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 5 01 256
Cytoplasm Texture SumVariance DAPI 10 01 256
Cytoplasm Granularity 1 mEGFP-LaminA
Cytoplasm Texture InfoMeas2 DAPI 20 01 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 20 03 256
Cytoplasm Texture SumVariance mEGFP-LaminA 20 00 256
NucleiExpanded Granularity 8 mEGFP-LaminA
NucleiExpanded Texture Contrast DAPI 20 01 256
Cytoplasm Granularity 7 DAPI
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 20 00 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 10 02 256
Nuclei AreaShape MaxFeretDiameter
Cytoplasm Texture SumEntropy DAPI 20 00 256
Cytoplasm RadialDistribution MeanFrac DAPI 6of10
Cytoplasm Texture SumEntropy mEGFP-LaminA 10 00 256
NucleiExpanded Texture DifferenceEntropy DAPI 5 03 256
NucleiExpanded Intensity MaxIntensityEdge mEGFP-LaminA
NucleiExpanded Intensity MeanIntensityEdge DAPI
NucleiExpanded RadialDistribution MeanFrac DAPI 7of10
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 9of10
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 5 02 256
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 7of10
NuclearInterior Intensity StdIntensity DAPI
NucleiExpanded Texture Correlation DAPI 20 00 256
NucleiExpanded Texture Correlation DAPI 5 00 256
Intensity MedianIntensity mEGFP-LaminA
NucleiExpanded Intensity MassDisplacement mEGFP-LaminA
NucleiExpanded Texture Correlation mEGFP-LaminA 20 03 256
NucleiExpanded Texture InfoMeas2 DAPI 5 00 256
Cytoplasm Texture DifferenceVariance DAPI 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 5 00 256
NucleiExpanded Texture InfoMeas2 DAPI 10 00 256
NucleiExpanded Texture DifferenceEntropy DAPI 5 02 256
NucleiExpanded Texture Contrast DAPI 5 01 256
Cytoplasm Intensity MinIntensityEdge Ph+WGA
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 9of10
Cytoplasm Intensity StdIntensity DAPI
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 8of10
NucleiExpanded Texture Contrast DAPI 10 00 256
NuclearInterior Intensity MinIntensity DAPI
NucleiExpanded Texture SumAverage DAPI 5 01 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 20 03 256
NucleiExpanded Texture DifferenceVariance DAPI 5 03 256
NucleiExpanded Texture InfoMeas2 DAPI 10 01 256
Cytoplasm Texture Variance DAPI 5 01 256
Cytoplasm RadialDistribution FracAtD DAPI 7of10
AreaShape Compactness
Cytoplasm Texture InverseDifferenceMoment DAPI 5 03 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 10 00 256
Cytoplasm Texture SumAverage mEGFP-LaminA 10 02 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 5 03 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 5of10
Cytoplasm Texture Contrast mEGFP-LaminA 10 00 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 5 01 256
Cytoplasm Intensity IntegratedIntensityEdge mEGFP-LaminA
NucleiExpanded Granularity 2 mEGFP-LaminA
NucleiExpanded Texture InfoMeas1 DAPI 5 03 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 20 00 256
NucleiExpanded Texture Contrast mEGFP-LaminA 5 01 256
Cytoplasm Texture Entropy DAPI 10 02 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 10 00 256
Cytoplasm Intensity IntegratedIntensityEdge Mito
NucleiExpanded Texture Correlation mEGFP-LaminA 10 03 256
Cytoplasm Texture Correlation mEGFP-LaminA 10 01 256
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 20 02 256
Cytoplasm Texture Correlation DAPI 10 01 256
Cytoplasm Texture Variance mEGFP-LaminA 5 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 4of10
NucleiExpanded Texture Variance mEGFP-LaminA 5 02 256
Cytoplasm Texture SumVariance DAPI 10 02 256
Cytoplasm Texture Correlation mEGFP-LaminA 10 00 256
Cytoplasm Intensity MassDisplacement mEGFP-LaminA
Cytoplasm Intensity MinIntensityEdge mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 2of10
NucleiExpanded Texture Variance mEGFP-LaminA 10 02 256
Cytoplasm Texture Correlation mEGFP-LaminA 20 00 256
NucleiExpanded Texture Entropy mEGFP-LaminA 5 01 256
NucleiExpanded RadialDistribution RadialCV DAPI 7of10
Cytoplasm Granularity 11 mEGFP-LaminA
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 5 00 256
NucleiExpanded Texture SumAverage DAPI 20 01 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 20 01 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 20 03 256
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 5 02 256
NuclearInterior Intensity MeanIntensityEdge mEGFP-LaminA
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 5 00 256
NucleiExpanded Texture Correlation DAPI 5 03 256
AreaShape FormFactor
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 10 01 256
NucleiExpanded Intensity StdIntensityEdge DAPI
NucleiExpanded Intensity MADIntensity mEGFP-LaminA
NuclearInterior Intensity StdIntensity mEGFP-LaminA
NucleiExpanded Texture SumAverage DAPI 20 00 256
NucleiExpanded Texture InfoMeas1 DAPI 5 00 256
NucleiExpanded Texture SumVariance DAPI 20 03 256
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 8of10
NucleiExpanded Granularity 10 mEGFP-LaminA
Nuclei AreaShape MinorAxisLength
NucleiExpanded Texture InfoMeas1 DAPI 20 01 256
Cytoplasm RadialDistribution RadialCV DAPI 7of10
Cytoplasm Texture SumAverage mEGFP-LaminA 10 01 256
NucleiExpanded Intensity MinIntensity DAPI
AreaShape MedianRadius
NucleiExpanded Texture DifferenceVariance DAPI 20 02 256
NucleiExpanded Texture Entropy mEGFP-LaminA 20 03 256
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 10 02 256
Cytoplasm Intensity MeanIntensityEdge Mito
Cytoplasm Texture InfoMeas1 DAPI 20 01 256
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 20 03 256
NucleiExpanded RadialDistribution RadialCV DAPI 1of10
Cytoplasm RadialDistribution MeanFrac Ph+WGA 2of5
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 6of10
Cytoplasm Texture InverseDifferenceMoment DAPI 20 02 256
Cytoplasm Texture SumAverage mEGFP-LaminA 10 00 256
Intensity LowerQuartileIntensity mEGFP-LaminA
Cytoplasm Intensity MeanIntensityEdge Ph+WGA
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 10 00 256
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 5 02 256
NucleiExpanded Texture InfoMeas2 DAPI 20 03 256
NucleiExpanded RadialDistribution MeanFrac DAPI 5of10
Cytoplasm Texture Entropy DAPI 20 03 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 20 02 256
Cytoplasm Texture Variance mEGFP-LaminA 20 00 256
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 6of10
Cytoplasm RadialDistribution FracAtD Ph+WGA 4of5
Cytoplasm Texture Entropy mEGFP-LaminA 20 01 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 10 02 256
Intensity MinIntensity mEGFP-LaminA
NucleiExpanded Texture SumEntropy DAPI 5 03 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 3of10
Cytoplasm Texture Correlation mEGFP-LaminA 20 03 256
NucleiExpanded Intensity IntegratedIntensityEdge DAPI
NucleiExpanded Texture Correlation DAPI 20 02 256
Cytoplasm Texture DifferenceEntropy DAPI 10 00 256
NucleiExpanded Texture SumAverage DAPI 10 03 256
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 9of10
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 5 03 256
Cytoplasm Texture InfoMeas2 DAPI 5 01 256
NucleiExpanded Texture Entropy mEGFP-LaminA 20 00 256
Cytoplasm RadialDistribution FracAtD DAPI 6of10
NucleiExpanded Texture DifferenceEntropy DAPI 10 01 256
Cytoplasm Texture Correlation DAPI 20 03 256
NucleiExpanded Texture Contrast mEGFP-LaminA 5 02 256
NucleiExpanded Texture Variance DAPI 10 03 256
NuclearBoundary Intensity MaxIntensityEdge mEGFP-LaminA
Cytoplasm Texture InfoMeas1 DAPI 10 02 256
NucleiExpanded Intensity MADIntensity DAPI
NucleiExpanded Texture Correlation DAPI 5 02 256
Neighbors SecondClosestDistance 30
NucleiExpanded Granularity 10 DAPI
Cytoplasm Intensity MinIntensity mEGFP-LaminA
Cytoplasm Texture Contrast mEGFP-LaminA 10 02 256
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 3of10
NucleiExpanded Texture Variance DAPI 20 02 256
Cytoplasm Granularity 4 DAPI
Neighbors AngleBetweenNeighbors Adjacent
NucleiExpanded Texture DifferenceEntropy DAPI 20 01 256
Cytoplasm Texture Correlation mEGFP-LaminA 20 02 256
NuclearInterior Intensity MADIntensity mEGFP-LaminA
NucleiExpanded Texture Contrast mEGFP-LaminA 10 00 256
Cytoplasm Intensity IntegratedIntensityEdge DAPI
NucleiExpanded Texture Entropy DAPI 20 02 256
Cytoplasm Texture Entropy mEGFP-LaminA 10 02 256
Cytoplasm Texture Variance mEGFP-LaminA 20 02 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 4of10
Cytoplasm Texture SumVariance mEGFP-LaminA 20 03 256
NucleiExpanded Texture Contrast mEGFP-LaminA 10 01 256
Cytoplasm Texture SumEntropy DAPI 20 01 256
Intensity MADIntensity mEGFP-LaminA
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 20 02 256
NucleiExpanded RadialDistribution RadialCV DAPI 10of10
NucleiExpanded Texture InverseDifferenceMoment DAPI 20 02 256
Cytoplasm Texture InfoMeas2 DAPI 10 02 256
NucleiExpanded Texture Correlation mEGFP-LaminA 20 02 256
Cytoplasm RadialDistribution MeanFrac Ph+WGA 3of5
NucleiExpanded Texture InfoMeas1 DAPI 5 02 256
NucleiExpanded Texture SumEntropy DAPI 20 01 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 10 01 256
Cytoplasm Texture Correlation DAPI 5 00 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 20 01 256
Cytoplasm Texture Contrast mEGFP-LaminA 5 01 256
NuclearBoundary Intensity MADIntensity DAPI
NuclearBoundary Correlation RWC mEGFP-LaminA DAPI
Cytoplasm Texture SumEntropy DAPI 20 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 5of10
Cytoplasm Correlation K mEGFP-LaminA DAPI
Cytoplasm Texture DifferenceVariance DAPI 20 01 256
NucleiExpanded Texture InfoMeas2 DAPI 20 02 256
Cytoplasm Intensity StdIntensityEdge DAPI
NuclearInterior Intensity MeanIntensity DAPI
NucleiExpanded Texture InfoMeas1 DAPI 20 00 256
Cytoplasm Texture Entropy mEGFP-LaminA 10 01 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 5 01 256
Cytoplasm Texture Variance DAPI 20 03 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 20 00 256
NuclearInterior Intensity MassDisplacement DAPI
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 10 03 256
NucleiExpanded Texture Variance mEGFP-LaminA 10 00 256
Cytoplasm Intensity MADIntensity mEGFP-LaminA
NucleiExpanded Intensity IntegratedIntensityEdge mEGFP-LaminA
Cytoplasm Texture Entropy mEGFP-LaminA 5 03 256
Cytoplasm RadialDistribution MeanFrac Mito 2of5
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 20 03 256
Cytoplasm Intensity MedianIntensity mEGFP-LaminA
NuclearBoundary Intensity StdIntensity DAPI
NucleiExpanded Texture Contrast mEGFP-LaminA 20 03 256
NucleiExpanded Texture SumEntropy DAPI 20 02 256
NucleiExpanded Texture DifferenceVariance DAPI 5 01 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 5 02 256
NucleiExpanded Correlation K DAPI mEGFP-LaminA
NucleiExpanded Texture Variance mEGFP-LaminA 5 01 256
NucleiExpanded Texture SumVariance DAPI 5 03 256
Cytoplasm Texture InfoMeas2 DAPI 10 01 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 20 00 256
Cytoplasm RadialDistribution FracAtD Mito 1of5
NucleiExpanded Texture Variance DAPI 10 01 256
Cytoplasm Intensity StdIntensity Mito
NucleiExpanded Texture Entropy mEGFP-LaminA 5 03 256
Cytoplasm Texture Entropy mEGFP-LaminA 10 03 256
NucleiExpanded RadialDistribution FracAtD DAPI 2of10
Cytoplasm Granularity 5 mEGFP-LaminA
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 1of10
Cytoplasm Texture Correlation DAPI 20 02 256
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 5 01 256
Cytoplasm Texture DifferenceEntropy DAPI 20 03 256
NucleiExpanded Granularity 13 DAPI
NuclearBoundary Intensity IntegratedIntensityEdge DAPI
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 20 00 256
Cytoplasm Texture Contrast DAPI 5 02 256
Cytoplasm Texture InfoMeas1 DAPI 5 00 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 10 00 256
NucleiExpanded RadialDistribution MeanFrac DAPI 4of10
NuclearInterior Intensity MeanIntensityEdge DAPI
Intensity MinIntensityEdge mEGFP-LaminA
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 20 00 256
Cytoplasm RadialDistribution MeanFrac DAPI 4of10
Cytoplasm Texture Correlation DAPI 10 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 5 02 256
Correlation Manders DAPI mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac DAPI 8of10
Cytoplasm Texture SumAverage DAPI 20 02 256
NucleiExpanded Granularity 11 mEGFP-LaminA
NucleiExpanded Granularity 8 DAPI
NucleiExpanded Granularity 15 DAPI
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 5 00 256
Cytoplasm Intensity StdIntensityEdge mEGFP-LaminA
Cytoplasm Intensity LowerQuartileIntensity DAPI
NucleiExpanded RadialDistribution FracAtD DAPI 9of10
Cytoplasm Texture InfoMeas2 DAPI 10 03 256
NucleiExpanded RadialDistribution MeanFrac DAPI 3of10
Cytoplasm Intensity MeanIntensity Ph+WGA
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 10 00 256
Cytoplasm Texture Contrast DAPI 20 02 256
NuclearInterior Intensity MinIntensityEdge DAPI
Cytoplasm Intensity MinIntensityEdge Mito
Cytoplasm Texture Variance mEGFP-LaminA 5 01 256
Cytoplasm Texture SumAverage DAPI 10 02 256
NucleiExpanded RadialDistribution MeanFrac DAPI 10of10
Cytoplasm Intensity MaxIntensityEdge mEGFP-LaminA
Cytoplasm Texture InverseDifferenceMoment DAPI 10 00 256
Cytoplasm Texture Variance mEGFP-LaminA 5 00 256
Cytoplasm Texture InfoMeas1 DAPI 10 03 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 5 03 256
Cytoplasm Texture SumVariance mEGFP-LaminA 10 03 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 20 01 256
NucleiExpanded RadialDistribution FracAtD DAPI 6of10
Cytoplasm Texture Entropy mEGFP-LaminA 5 00 256
NucleiExpanded Texture InfoMeas1 DAPI 20 02 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 10 02 256
NuclearBoundary Intensity MeanIntensityEdge DAPI
NucleiExpanded Texture SumAverage mEGFP-LaminA 10 01 256
NucleiExpanded Texture SumAverage DAPI 5 00 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 10 00 256
Cytoplasm Intensity MinIntensity DAPI
Cytoplasm Texture Correlation DAPI 20 00 256
NuclearInterior Correlation Manders DAPI mEGFP-LaminA
Cytoplasm Texture Correlation DAPI 10 00 256
Cytoplasm Texture SumAverage mEGFP-LaminA 20 03 256
Cytoplasm Intensity MaxIntensityEdge Mito
NucleiExpanded Texture Contrast mEGFP-LaminA 20 00 256
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 20 03 256
Nuclei AreaShape MinFeretDiameter
NuclearBoundary Intensity StdIntensityEdge mEGFP-LaminA
NucleiExpanded Texture Entropy mEGFP-LaminA 10 01 256
NucleiExpanded RadialDistribution FracAtD DAPI 4of10
NucleiExpanded Texture InfoMeas1 DAPI 10 01 256
Cytoplasm Texture InverseDifferenceMoment DAPI 10 03 256
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 10 01 256
NucleiExpanded Texture Entropy DAPI 5 02 256
Cytoplasm Intensity IntegratedIntensity mEGFP-LaminA
NuclearBoundary Intensity UpperQuartileIntensity DAPI
Cytoplasm Texture InfoMeas1 DAPI 20 03 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 10 03 256
Cytoplasm Texture Correlation DAPI 20 01 256
Cytoplasm Texture SumVariance DAPI 20 00 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 5 01 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 10 01 256
NuclearBoundary Intensity IntegratedIntensity mEGFP-LaminA
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 6of10
Cytoplasm Texture SumEntropy mEGFP-LaminA 5 00 256
Cytoplasm Texture Contrast DAPI 10 02 256
Cytoplasm Intensity MeanIntensity mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac Ph+WGA 4of5
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 3of10
Cytoplasm RadialDistribution RadialCV DAPI 2of10
NucleiExpanded Texture Entropy mEGFP-LaminA 20 01 256
Cytoplasm RadialDistribution FracAtD Mito 4of5
Cytoplasm Texture Variance mEGFP-LaminA 10 00 256
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 10of10
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 20 01 256
NucleiExpanded Texture Variance DAPI 5 03 256
Cytoplasm Texture SumAverage DAPI 5 00 256
Cytoplasm RadialDistribution RadialCV DAPI 4of10
NucleiExpanded Texture Correlation mEGFP-LaminA 10 01 256
Cytoplasm Texture Correlation mEGFP-LaminA 10 03 256
NucleiExpanded Granularity 5 DAPI
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 20 03 256
Cytoplasm Texture Variance DAPI 10 03 256
Cytoplasm Correlation RWC DAPI mEGFP-LaminA
Cytoplasm Texture SumEntropy DAPI 5 02 256
Cytoplasm Texture Entropy DAPI 20 00 256
NuclearInterior Intensity StdIntensityEdge mEGFP-LaminA
NucleiExpanded Texture Variance mEGFP-LaminA 20 01 256
NucleiExpanded RadialDistribution FracAtD DAPI 5of10
Cytoplasm Texture Contrast DAPI 10 00 256
Cytoplasm Texture Correlation mEGFP-LaminA 5 03 256
NucleiExpanded Texture InfoMeas1 DAPI 20 03 256
Intensity MeanIntensityEdge mEGFP-LaminA
Cytoplasm Texture InfoMeas2 DAPI 5 03 256
Cytoplasm Texture DifferenceEntropy DAPI 10 03 256
NucleiExpanded Texture Contrast DAPI 10 02 256
Cytoplasm Texture Entropy DAPI 5 03 256
Cytoplasm Texture Variance mEGFP-LaminA 10 03 256
Cytoplasm RadialDistribution MeanFrac DAPI 9of10
Intensity StdIntensity DAPI
NucleiExpanded Texture SumVariance mEGFP-LaminA 20 00 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 20 03 256
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 9of10
NuclearBoundary Intensity MinIntensityEdge mEGFP-LaminA
Cytoplasm Texture SumEntropy DAPI 10 02 256
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 5of10
Cytoplasm Texture InverseDifferenceMoment DAPI 5 00 256
Cytoplasm Texture SumVariance DAPI 5 02 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 20 00 256
Cytoplasm Texture SumAverage DAPI 10 03 256
AreaShape Extent
Cytoplasm Granularity 10 mEGFP-LaminA
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 20 02 256
Cytoplasm RadialDistribution FracAtD Mito 5of5
NucleiExpanded Texture Contrast mEGFP-LaminA 10 03 256
Cytoplasm Texture Correlation mEGFP-LaminA 5 02 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 20 01 256
AreaShape Area
Correlation RWC mEGFP-LaminA DAPI
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 4of10
Correlation K mEGFP-LaminA DAPI
Correlation Costes DAPI mEGFP-LaminA
NucleiExpanded Texture Contrast DAPI 20 02 256
Cytoplasm Granularity 1 DAPI
Intensity IntegratedIntensity mEGFP-LaminA
Nuclei Neighbors AngleBetweenNeighbors 10
NuclearInterior Intensity MaxIntensityEdge mEGFP-LaminA
Cytoplasm Texture Entropy mEGFP-LaminA 5 02 256
Cytoplasm Texture Contrast mEGFP-LaminA 10 01 256
Cytoplasm Intensity UpperQuartileIntensity Mito
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 20 01 256
NucleiExpanded Granularity 1 mEGFP-LaminA
NuclearInterior Correlation Overlap DAPI mEGFP-LaminA
NucleiExpanded Correlation Manders DAPI mEGFP-LaminA
Nuclei AreaShape Compactness
NucleiExpanded Texture InfoMeas1 DAPI 10 00 256
Cytoplasm Texture Contrast mEGFP-LaminA 20 02 256
NucleiExpanded Texture Variance mEGFP-LaminA 5 00 256
NucleiExpanded Texture DifferenceVariance DAPI 10 00 256
NucleiExpanded Texture SumVariance DAPI 5 01 256
Cytoplasm Texture SumEntropy mEGFP-LaminA 10 02 256
Cytoplasm Texture InfoMeas1 DAPI 5 02 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 10 00 256
Cytoplasm Texture Contrast DAPI 5 01 256
NucleiExpanded RadialDistribution FracAtD DAPI 10of10
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 3of10
Cytoplasm Granularity 9 mEGFP-LaminA
NucleiExpanded Texture Entropy DAPI 5 03 256
Cytoplasm Texture Variance mEGFP-LaminA 20 03 256
Cytoplasm RadialDistribution RadialCV Ph+WGA 1of5
NuclearBoundary Intensity LowerQuartileIntensity DAPI
NucleiExpanded Texture SumAverage mEGFP-LaminA 20 03 256
Cytoplasm Texture Variance DAPI 20 01 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 10 01 256
Cytoplasm Granularity 3 DAPI
NucleiExpanded Texture InfoMeas1 DAPI 5 01 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 6of10
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 10 02 256
Cytoplasm Granularity 2 DAPI
NucleiExpanded Texture Variance DAPI 5 01 256
Cytoplasm Texture Variance DAPI 10 02 256
Correlation K DAPI mEGFP-LaminA
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 8of10
NuclearInterior Intensity MedianIntensity DAPI
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 5 00 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 7of10
Cytoplasm Texture SumVariance mEGFP-LaminA 10 00 256
Cytoplasm Texture SumVariance DAPI 20 02 256
Cytoplasm Texture Variance DAPI 5 00 256
Cytoplasm Texture DifferenceEntropy DAPI 20 02 256
Cytoplasm Granularity 8 DAPI
Cytoplasm Texture SumVariance mEGFP-LaminA 20 02 256
NucleiExpanded Texture InfoMeas2 DAPI 10 03 256
NucleiExpanded Granularity 3 mEGFP-LaminA
NucleiExpanded Texture InfoMeas1 DAPI 10 02 256
NucleiExpanded Texture Correlation DAPI 20 01 256
Cytoplasm Intensity LowerQuartileIntensity mEGFP-LaminA
Cytoplasm Texture SumAverage mEGFP-LaminA 20 02 256
NucleiExpanded Texture Entropy mEGFP-LaminA 10 00 256
NuclearBoundary Intensity MeanIntensityEdge mEGFP-LaminA
Correlation RWC DAPI mEGFP-LaminA
Cytoplasm Correlation Manders mEGFP-LaminA DAPI
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 2of10
NucleiExpanded Texture DifferenceVariance DAPI 5 02 256
Cytoplasm Texture InfoMeas2 DAPI 20 00 256
Cytoplasm Texture SumVariance DAPI 5 03 256
NucleiExpanded Texture Variance mEGFP-LaminA 20 03 256
Cytoplasm Intensity MinIntensity Ph+WGA
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 10of10
NucleiExpanded Granularity 14 DAPI
Cytoplasm Texture InverseDifferenceMoment DAPI 5 01 256
NucleiExpanded Intensity MedianIntensity DAPI
NucleiExpanded Texture DifferenceEntropy DAPI 20 02 256
Cytoplasm RadialDistribution FracAtD DAPI 4of10
Intensity MinIntensityEdge DAPI
Cytoplasm Texture InverseDifferenceMoment DAPI 10 01 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 10 01 256
Cytoplasm Texture InfoMeas1 DAPI 10 01 256
NucleiExpanded Intensity MaxIntensity DAPI
Cytoplasm Texture Correlation DAPI 5 01 256
Cytoplasm Texture Variance mEGFP-LaminA 10 02 256
Intensity MedianIntensity DAPI
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 10 01 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 10 02 256
Cytoplasm Intensity IntegratedIntensity Ph+WGA
Cytoplasm Texture Contrast mEGFP-LaminA 5 03 256
NucleiExpanded Texture SumEntropy DAPI 5 01 256
Cytoplasm Texture SumVariance mEGFP-LaminA 10 01 256
Correlation Overlap DAPI mEGFP-LaminA
Cytoplasm Granularity 13 DAPI
Nuclei Neighbors SecondClosestDistance 10
Cytoplasm Texture DifferenceEntropy DAPI 5 01 256
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 5 00 256
Cytoplasm Texture Contrast DAPI 20 03 256
NucleiExpanded Texture InfoMeas2 DAPI 5 03 256
Cytoplasm Texture Entropy mEGFP-LaminA 20 00 256
Cytoplasm Texture DifferenceVariance DAPI 5 03 256
Cytoplasm RadialDistribution RadialCV Ph+WGA 3of5
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 5 01 256
NuclearBoundary Intensity MaxIntensity DAPI
NucleiExpanded Texture SumVariance mEGFP-LaminA 20 01 256
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 6of10
Cytoplasm Texture DifferenceEntropy DAPI 10 01 256
NucleiExpanded Texture InfoMeas2 DAPI 20 01 256
NucleiExpanded Intensity IntegratedIntensity DAPI
NucleiExpanded Texture SumEntropy mEGFP-LaminA 10 02 256
Cytoplasm Texture Entropy DAPI 5 01 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 10 00 256
Cytoplasm Texture DifferenceEntropy DAPI 10 02 256
NuclearBoundary Intensity StdIntensity mEGFP-LaminA
NucleiExpanded Texture Correlation mEGFP-LaminA 20 00 256
Cytoplasm Granularity 2 mEGFP-LaminA
Cytoplasm RadialDistribution FracAtD DAPI 8of10
NucleiExpanded Texture DifferenceEntropy DAPI 10 02 256
Cytoplasm Texture Variance DAPI 10 00 256
NucleiExpanded Intensity MassDisplacement DAPI
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 10 01 256
Cytoplasm RadialDistribution FracAtD Mito 2of5
Neighbors AngleBetweenNeighbors 30
Nuclei AreaShape Solidity
NucleiExpanded Correlation Overlap DAPI mEGFP-LaminA
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 1of10
Cytoplasm Texture SumEntropy mEGFP-LaminA 5 02 256
NuclearBoundary Correlation Overlap DAPI mEGFP-LaminA
NucleiExpanded Texture InverseDifferenceMoment DAPI 5 01 256
NucleiExpanded Granularity 7 DAPI
Cytoplasm Texture SumVariance mEGFP-LaminA 20 01 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 10 02 256
NucleiExpanded Texture SumAverage DAPI 5 03 256
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 20 02 256
NucleiExpanded Texture Entropy DAPI 20 01 256
NucleiExpanded Texture Variance DAPI 20 00 256
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 10 02 256
NucleiExpanded Intensity MinIntensityEdge mEGFP-LaminA
Cytoplasm Texture SumEntropy mEGFP-LaminA 20 03 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 20 02 256
Cytoplasm Texture SumAverage DAPI 20 03 256
NuclearBoundary Intensity StdIntensityEdge DAPI
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 5 01 256
Nuclei AreaShape MajorAxisLength
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 8of10
Cytoplasm Granularity 10 DAPI
Cytoplasm RadialDistribution MeanFrac Ph+WGA 1of5
NucleiExpanded Texture Entropy mEGFP-LaminA 10 02 256
NucleiExpanded Texture DifferenceEntropy DAPI 5 00 256
Cytoplasm Texture SumAverage DAPI 20 01 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 10 02 256
NuclearBoundary Intensity MassDisplacement mEGFP-LaminA
NuclearInterior Intensity LowerQuartileIntensity DAPI
Cytoplasm Texture Entropy DAPI 5 00 256
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 4of10
NucleiExpanded Intensity StdIntensityEdge mEGFP-LaminA
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 5 02 256
NuclearInterior Intensity MADIntensity DAPI
NucleiExpanded RadialDistribution MeanFrac DAPI 6of10
NucleiExpanded Intensity MaxIntensity mEGFP-LaminA
Cytoplasm Texture Correlation mEGFP-LaminA 5 00 256
Cytoplasm Texture DifferenceVariance DAPI 10 01 256
Cytoplasm Correlation Costes DAPI mEGFP-LaminA
Cytoplasm Texture Entropy DAPI 5 02 256
Nuclei Neighbors PercentTouching 10
NucleiExpanded Texture DifferenceVariance DAPI 20 00 256
Cytoplasm Intensity MeanIntensity Mito
AreaShape Perimeter
Intensity MeanIntensity mEGFP-LaminA
NucleiExpanded Texture SumAverage DAPI 10 00 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 20 03 256
NucleiExpanded Intensity MinIntensity mEGFP-LaminA
Cytoplasm Texture Contrast mEGFP-LaminA 5 00 256
Neighbors FirstClosestDistance 30
NucleiExpanded Texture Entropy DAPI 20 00 256
NucleiExpanded Texture Variance mEGFP-LaminA 10 01 256
NuclearInterior Correlation K DAPI mEGFP-LaminA
Cytoplasm Correlation K DAPI mEGFP-LaminA
NuclearBoundary Intensity MeanIntensity DAPI
Cytoplasm Texture SumAverage DAPI 5 01 256
Neighbors FirstClosestDistance Adjacent
Cytoplasm Intensity MassDisplacement Ph+WGA
NuclearBoundary Correlation K DAPI mEGFP-LaminA
NucleiExpanded Texture SumEntropy mEGFP-LaminA 5 00 256
Cytoplasm Texture SumVariance DAPI 20 01 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 5 03 256
Nuclei AreaShape Extent
Cytoplasm Texture Variance DAPI 5 03 256
Cytoplasm Texture InfoMeas1 DAPI 20 02 256
Cytoplasm RadialDistribution RadialCV DAPI 8of10
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 20 01 256
Cytoplasm RadialDistribution RadialCV Ph+WGA 5of5
Cytoplasm Texture SumAverage mEGFP-LaminA 20 01 256
Cytoplasm Granularity 15 DAPI
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 2of10
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 4of10
Cytoplasm Texture Variance DAPI 10 01 256
Cytoplasm RadialDistribution RadialCV Mito 3of5
NucleiExpanded Texture SumEntropy DAPI 10 00 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 10 03 256
NucleiExpanded Texture SumAverage DAPI 10 01 256
Cytoplasm Texture SumEntropy mEGFP-LaminA 5 01 256
NucleiExpanded Texture Entropy mEGFP-LaminA 5 00 256
Cytoplasm Texture InverseDifferenceMoment DAPI 20 01 256
Cytoplasm RadialDistribution MeanFrac DAPI 2of10
Cytoplasm Texture SumVariance DAPI 20 03 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 20 00 256
Cytoplasm Texture Contrast mEGFP-LaminA 20 03 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 10 03 256
NuclearBoundary Correlation Manders DAPI mEGFP-LaminA
NucleiExpanded Texture SumVariance DAPI 20 02 256
NuclearBoundary Correlation Manders mEGFP-LaminA DAPI
Cytoplasm Texture Contrast mEGFP-LaminA 5 02 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 5 00 256
AreaShape Eccentricity
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 10 00 256
NucleiExpanded Granularity 3 DAPI
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 5 03 256
NucleiExpanded Texture Correlation mEGFP-LaminA 5 01 256
Cytoplasm RadialDistribution MeanFrac DAPI 10of10
NucleiExpanded Texture Variance DAPI 20 03 256
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 2of10
NucleiExpanded Texture Correlation DAPI 10 00 256
Cytoplasm Texture InverseDifferenceMoment DAPI 20 00 256
Cytoplasm Texture SumAverage mEGFP-LaminA 5 00 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 10 01 256
NucleiExpanded Texture DifferenceEntropy DAPI 20 03 256
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 5of10
Cytoplasm Intensity IntegratedIntensityEdge Ph+WGA
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 8of10
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 20 02 256
NucleiExpanded Texture SumVariance DAPI 20 00 256
NucleiExpanded Intensity UpperQuartileIntensity mEGFP-LaminA
Cytoplasm RadialDistribution RadialCV DAPI 10of10
NucleiExpanded RadialDistribution FracAtD DAPI 3of10
NucleiExpanded Texture Variance mEGFP-LaminA 10 03 256
NucleiExpanded Texture Entropy mEGFP-LaminA 10 03 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 20 01 256
Cytoplasm Texture SumEntropy mEGFP-LaminA 5 03 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 10 03 256
Cytoplasm Texture SumEntropy mEGFP-LaminA 10 03 256
NucleiExpanded Granularity 2 DAPI
NucleiExpanded Granularity 1 DAPI
Cytoplasm RadialDistribution FracAtD Mito 3of5
Cytoplasm Intensity IntegratedIntensity DAPI
Cytoplasm Texture SumEntropy DAPI 10 03 256
Cytoplasm Texture Variance DAPI 5 02 256
Nuclei AreaShape EquivalentDiameter
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 5 00 256
Cytoplasm Intensity StdIntensityEdge Ph+WGA
Cytoplasm Texture Entropy mEGFP-LaminA 20 02 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 20 00 256
Correlation Manders mEGFP-LaminA DAPI
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 20 01 256
Cytoplasm Texture InverseDifferenceMoment DAPI 20 03 256
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 5 00 256
Cytoplasm Texture DifferenceVariance DAPI 5 02 256
NucleiExpanded Texture Entropy DAPI 5 00 256
NucleiExpanded Texture Variance DAPI 5 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 9of10
Intensity UpperQuartileIntensity DAPI
Cytoplasm Texture Contrast mEGFP-LaminA 20 00 256
Cytoplasm Texture DifferenceVariance DAPI 5 01 256
Cytoplasm RadialDistribution MeanFrac Mito 1of5
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 10 01 256
NucleiExpanded Texture SumEntropy DAPI 5 02 256
Cytoplasm Texture SumAverage mEGFP-LaminA 5 02 256
Cytoplasm RadialDistribution RadialCV DAPI 3of10
Neighbors SecondClosestDistance Adjacent
NucleiExpanded Granularity 6 DAPI
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 10of10
Cytoplasm Granularity 7 mEGFP-LaminA
Cytoplasm Texture SumEntropy mEGFP-LaminA 20 01 256
NucleiExpanded RadialDistribution FracAtD DAPI 8of10
NucleiExpanded Texture SumEntropy DAPI 10 02 256
Cytoplasm Texture InfoMeas1 DAPI 5 03 256
Cytoplasm Correlation Overlap DAPI mEGFP-LaminA
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 20 01 256
NucleiExpanded Texture Correlation DAPI 10 03 256
NucleiExpanded Texture InverseDifferenceMoment DAPI 5 00 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 5 00 256
NucleiExpanded Texture Correlation mEGFP-LaminA 10 02 256
Cytoplasm RadialDistribution MeanFrac Mito 4of5
NucleiExpanded Texture SumEntropy DAPI 5 00 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 20 01 256
Nuclei AreaShape MedianRadius
NucleiExpanded Texture Correlation mEGFP-LaminA 5 02 256
Cytoplasm Texture SumEntropy DAPI 5 03 256
Cytoplasm Texture SumEntropy mEGFP-LaminA 10 01 256
NucleiExpanded Granularity 7 mEGFP-LaminA
Cytoplasm Texture SumAverage mEGFP-LaminA 5 03 256
Cytoplasm Texture SumEntropy DAPI 5 00 256
NuclearBoundary Correlation K mEGFP-LaminA DAPI
Cytoplasm Texture SumAverage DAPI 10 01 256
Cytoplasm Texture InfoMeas1 DAPI 20 00 256
Cytoplasm Intensity MaxIntensity Mito
Cytoplasm Intensity MedianIntensity Ph+WGA
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 5 01 256
Cytoplasm Texture InfoMeas1 DAPI 5 01 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 5 00 256
NucleiExpanded Texture Contrast DAPI 20 00 256
NuclearBoundary Intensity MinIntensity DAPI
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 20 01 256
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 4of10
NuclearBoundary Intensity MaxIntensityEdge DAPI
Cytoplasm Intensity MedianIntensity Mito
NucleiExpanded Texture Entropy mEGFP-LaminA 5 02 256
NucleiExpanded Granularity 9 DAPI
NucleiExpanded Texture SumVariance DAPI 5 00 256
NuclearInterior Intensity MaxIntensity DAPI
NucleiExpanded Texture Contrast mEGFP-LaminA 20 01 256
Cytoplasm Texture SumAverage mEGFP-LaminA 20 00 256
Cytoplasm Texture DifferenceVariance DAPI 10 02 256
NucleiExpanded Intensity MeanIntensity DAPI
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 1of10
NucleiExpanded Granularity 11 DAPI
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 5 03 256
Cytoplasm Texture Correlation DAPI 10 03 256
Cytoplasm Texture SumVariance mEGFP-LaminA 5 03 256
Cytoplasm Texture Correlation DAPI 5 03 256
AreaShape Solidity
Cytoplasm Texture DifferenceVariance DAPI 20 03 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 10 03 256
NucleiExpanded Granularity 6 mEGFP-LaminA
NucleiExpanded Intensity LowerQuartileIntensity DAPI
NucleiExpanded Texture DifferenceVariance DAPI 20 03 256
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 10 00 256
NucleiExpanded RadialDistribution RadialCV DAPI 4of10
AreaShape MinorAxisLength
NucleiExpanded Texture InverseDifferenceMoment DAPI 5 03 256
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 5 03 256
Cytoplasm Texture Contrast DAPI 20 00 256
Cytoplasm Intensity MaxIntensityEdge DAPI
NucleiExpanded Correlation RWC mEGFP-LaminA DAPI
Cytoplasm Texture SumAverage DAPI 10 00 256
NucleiExpanded Texture SumAverage DAPI 20 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 3of10
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 5 02 256
NucleiExpanded Texture SumVariance DAPI 10 03 256
NucleiExpanded Texture Variance mEGFP-LaminA 20 02 256
NucleiExpanded Texture Contrast DAPI 5 03 256
Cytoplasm Texture Contrast DAPI 20 01 256
Cytoplasm Texture Entropy DAPI 20 01 256
NucleiExpanded Texture SumAverage DAPI 10 02 256
NuclearInterior Intensity LowerQuartileIntensity mEGFP-LaminA
NucleiExpanded Texture SumEntropy DAPI 20 00 256
Cytoplasm Texture Entropy mEGFP-LaminA 20 03 256
NuclearInterior Intensity MaxIntensityEdge DAPI
Nuclei Neighbors NumberOfNeighbors 10
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 10 03 256
AreaShape MaximumRadius
Cytoplasm Intensity StdIntensityEdge Mito
NucleiExpanded Intensity MeanIntensityEdge mEGFP-LaminA
Cytoplasm RadialDistribution FracAtD Ph+WGA 3of5
Nuclei AreaShape FormFactor
Cytoplasm Texture Entropy DAPI 10 01 256
Cytoplasm Texture SumVariance mEGFP-LaminA 5 00 256
NucleiExpanded Texture SumVariance mEGFP-LaminA 5 03 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 8of10
Cytoplasm Correlation Manders DAPI mEGFP-LaminA
Cytoplasm Granularity 4 mEGFP-LaminA
Cytoplasm Intensity MinIntensityEdge DAPI
NucleiExpanded RadialDistribution RadialCV DAPI 3of10
NucleiExpanded Texture SumAverage mEGFP-LaminA 10 03 256
NucleiExpanded Intensity LowerQuartileIntensity mEGFP-LaminA
NucleiExpanded RadialDistribution MeanFrac DAPI 9of10
NucleiExpanded Texture SumEntropy mEGFP-LaminA 10 03 256
Cytoplasm Texture Contrast DAPI 10 01 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 5 01 256
NucleiExpanded Correlation Correlation DAPI mEGFP-LaminA
NuclearBoundary Intensity MedianIntensity DAPI
Cytoplasm Intensity MaxIntensity DAPI
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 20 02 256
NucleiExpanded RadialDistribution FracAtD DAPI 1of10
Nuclei AreaShape MaximumRadius
NucleiExpanded Texture SumAverage mEGFP-LaminA 5 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 6of10
Cytoplasm Texture SumVariance mEGFP-LaminA 5 01 256
Cytoplasm Texture SumAverage mEGFP-LaminA 10 03 256
Cytoplasm RadialDistribution FracAtD Ph+WGA 2of5
Cytoplasm Granularity 5 DAPI
Cytoplasm Intensity UpperQuartileIntensity DAPI
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 9of10
NuclearInterior Correlation K mEGFP-LaminA DAPI
NucleiExpanded Texture SumEntropy DAPI 20 03 256
Cytoplasm Texture SumVariance DAPI 10 00 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 10 00 256
Cytoplasm Texture DifferenceVariance mEGFP-LaminA 5 00 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 5 03 256
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 10 01 256
Cytoplasm Texture SumVariance DAPI 5 00 256
NucleiExpanded Texture Contrast mEGFP-LaminA 5 00 256
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 2of10
NuclearBoundary Intensity IntegratedIntensity DAPI
Cytoplasm RadialDistribution MeanFrac DAPI 1of10
NucleiExpanded Texture InfoMeas2 DAPI 5 01 256
Intensity MeanIntensity DAPI
Intensity MaxIntensity DAPI
Cytoplasm Texture SumEntropy DAPI 20 03 256
Cytoplasm Intensity MaxIntensity mEGFP-LaminA
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 10 01 256
NucleiExpanded Texture DifferenceEntropy DAPI 10 03 256
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 10of10
NucleiExpanded Texture DifferenceVariance mEGFP-LaminA 10 03 256
Cytoplasm Texture Entropy mEGFP-LaminA 5 01 256
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 10 02 256
NucleiExpanded Texture Entropy DAPI 20 03 256
Intensity UpperQuartileIntensity mEGFP-LaminA
NucleiExpanded Texture SumAverage mEGFP-LaminA 10 00 256
NucleiExpanded Texture Contrast mEGFP-LaminA 10 02 256
Cytoplasm Intensity LowerQuartileIntensity Mito
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 20 03 256
NucleiExpanded Texture SumEntropy mEGFP-LaminA 5 02 256
NucleiExpanded Intensity MedianIntensity mEGFP-LaminA
Cytoplasm Texture Contrast DAPI 10 03 256
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 10 00 256
Cytoplasm Intensity UpperQuartileIntensity mEGFP-LaminA
NuclearInterior Intensity MinIntensity mEGFP-LaminA
Cytoplasm RadialDistribution RadialCV DAPI 6of10
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 5 02 256
Cytoplasm RadialDistribution RadialCV Mito 2of5
NucleiExpanded RadialDistribution RadialCV DAPI 8of10
NucleiExpanded Texture InverseDifferenceMoment DAPI 20 00 256
NucleiExpanded Texture Variance DAPI 10 00 256
Cytoplasm Intensity StdIntensity Ph+WGA
Intensity IntegratedIntensityEdge DAPI
Cytoplasm Correlation RWC mEGFP-LaminA DAPI
Nuclei AreaShape ConvexArea
Cytoplasm RadialDistribution RadialCV Ph+WGA 2of5
NucleiExpanded Granularity 9 mEGFP-LaminA
NucleiExpanded Texture InverseDifferenceMoment DAPI 10 00 256
Cytoplasm RadialDistribution RadialCV DAPI 1of10
Cytoplasm Granularity 11 DAPI
NucleiExpanded Texture SumVariance DAPI 20 01 256
Intensity StdIntensityEdge mEGFP-LaminA
Nuclei Neighbors FirstClosestDistance 10
NuclearBoundary Intensity MinIntensityEdge DAPI
Cytoplasm Granularity 6 mEGFP-LaminA
Cytoplasm Texture SumEntropy mEGFP-LaminA 20 00 256
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 1of10
Cytoplasm Granularity 14 DAPI
Cytoplasm Granularity 12 mEGFP-LaminA
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 10 03 256
Nuclei AreaShape Eccentricity
NuclearInterior Intensity IntegratedIntensity DAPI
NucleiExpanded Texture InfoMeas2 mEGFP-LaminA 20 02 256
NucleiExpanded Texture Correlation mEGFP-LaminA 20 01 256
Cytoplasm Intensity MassDisplacement DAPI
Intensity MaxIntensityEdge DAPI
NuclearInterior Intensity MaxIntensity mEGFP-LaminA
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 5 00 256
Cytoplasm Texture Contrast DAPI 5 00 256
Cytoplasm RadialDistribution FracAtD DAPI 10of10
Cytoplasm Texture Correlation mEGFP-LaminA 10 02 256
Cytoplasm RadialDistribution MeanFrac DAPI 7of10
Cytoplasm Granularity 6 DAPI
NucleiExpanded Texture SumEntropy mEGFP-LaminA 5 03 256
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 10of10
NucleiExpanded Texture SumVariance mEGFP-LaminA 5 02 256
NucleiExpanded RadialDistribution MeanFrac DAPI 2of10
NucleiExpanded Texture InfoMeas2 DAPI 5 02 256
NucleiExpanded Texture InfoMeas1 DAPI 10 03 256
Cytoplasm Texture InfoMeas1 DAPI 10 00 256
Cytoplasm RadialDistribution MeanFrac Mito 5of5
NucleiExpanded RadialDistribution MeanFrac DAPI 1of10
Cytoplasm Texture SumAverage mEGFP-LaminA 5 01 256
Cytoplasm Texture DifferenceVariance DAPI 5 00 256
NuclearInterior Intensity MassDisplacement mEGFP-LaminA
Intensity MassDisplacement mEGFP-LaminA
NucleiExpanded RadialDistribution MeanFrac DAPI 8of10
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 10 02 256
NucleiExpanded Texture SumEntropy DAPI 10 01 256
Cytoplasm Texture SumVariance mEGFP-LaminA 10 02 256
NucleiExpanded Texture DifferenceEntropy DAPI 5 01 256
NuclearInterior Correlation Correlation DAPI mEGFP-LaminA
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 20 02 256
Cytoplasm Intensity LowerQuartileIntensity Ph+WGA
NucleiExpanded Texture SumEntropy mEGFP-LaminA 20 03 256
NucleiExpanded Texture Variance mEGFP-LaminA 20 00 256
Cytoplasm Texture Entropy DAPI 10 03 256
NucleiExpanded Texture SumAverage DAPI 5 02 256
Cytoplasm RadialDistribution RadialCV DAPI 9of10
NucleiExpanded Texture SumAverage DAPI 20 03 256
Cytoplasm Intensity MaxIntensityEdge Ph+WGA
NucleiExpanded Texture InverseDifferenceMoment DAPI 5 02 256
Intensity StdIntensityEdge DAPI
NuclearBoundary Intensity LowerQuartileIntensity mEGFP-LaminA
Cytoplasm Texture InfoMeas1 mEGFP-LaminA 20 00 256
NuclearBoundary Correlation Correlation DAPI mEGFP-LaminA
Cytoplasm Texture Contrast mEGFP-LaminA 10 03 256
NuclearInterior Correlation RWC mEGFP-LaminA DAPI
NucleiExpanded Texture Entropy DAPI 10 02 256
NucleiExpanded Texture Entropy mEGFP-LaminA 20 02 256
NuclearInterior Intensity IntegratedIntensityEdge mEGFP-LaminA
NucleiExpanded RadialDistribution FracAtD mEGFP-LaminA 5of10
NucleiExpanded Texture InfoMeas1 mEGFP-LaminA 10 02 256
Intensity MassDisplacement DAPI
Cytoplasm RadialDistribution FracAtD DAPI 9of10
AreaShape MinFeretDiameter
NucleiExpanded Texture Correlation DAPI 20 03 256
Cytoplasm Texture SumVariance DAPI 5 01 256
Cytoplasm Granularity 3 mEGFP-LaminA
Cytoplasm Texture SumEntropy mEGFP-LaminA 20 02 256
Correlation Correlation DAPI mEGFP-LaminA
Cytoplasm Texture Variance mEGFP-LaminA 5 03 256
Nuclei AreaShape Perimeter
NucleiExpanded Texture DifferenceVariance DAPI 10 03 256
Cytoplasm Texture InfoMeas2 DAPI 5 02 256
Cytoplasm Texture DifferenceVariance DAPI 20 02 256
Cytoplasm RadialDistribution FracAtD DAPI 5of10
Cytoplasm RadialDistribution FracAtD mEGFP-LaminA 2of10
NucleiExpanded Texture SumVariance mEGFP-LaminA 20 02 256
NucleiExpanded Texture DifferenceVariance DAPI 20 01 256
Cytoplasm Texture SumAverage DAPI 5 02 256
NucleiExpanded Texture Contrast mEGFP-LaminA 5 03 256
Cytoplasm Texture DifferenceEntropy DAPI 20 01 256
Cytoplasm RadialDistribution FracAtD DAPI 3of10
Cytoplasm Granularity 12 DAPI
NucleiExpanded Texture Correlation mEGFP-LaminA 5 00 256
Cytoplasm Texture Contrast mEGFP-LaminA 20 01 256
Cytoplasm Texture Variance DAPI 20 00 256
Cytoplasm Texture InfoMeas2 mEGFP-LaminA 5 02 256
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 7of10
NucleiExpanded Texture InverseDifferenceMoment mEGFP-LaminA 5 03 256
Cytoplasm RadialDistribution RadialCV mEGFP-LaminA 3of10
NucleiExpanded RadialDistribution RadialCV mEGFP-LaminA 5of10
NucleiExpanded Texture DifferenceEntropy mEGFP-LaminA 5 01 256
Cytoplasm Intensity MaxIntensity Ph+WGA
NucleiExpanded Texture Contrast DAPI 10 03 256
NuclearBoundary Intensity MinIntensity mEGFP-LaminA
NuclearInterior Intensity MedianIntensity mEGFP-LaminA
Cytoplasm Texture Entropy DAPI 10 00 256
NucleiExpanded Texture SumVariance DAPI 10 00 256
Cytoplasm Texture Correlation DAPI 5 02 256
NucleiExpanded Intensity MaxIntensityEdge DAPI
NucleiExpanded Texture DifferenceVariance DAPI 10 01 256
NucleiExpanded Texture Correlation mEGFP-LaminA 5 03 256
Cytoplasm Texture SumEntropy DAPI 10 00 256
NuclearBoundary Intensity MADIntensity mEGFP-LaminA
NuclearBoundary Intensity MaxIntensity mEGFP-LaminA
Intensity StdIntensity mEGFP-LaminA
NucleiExpanded Texture Correlation mEGFP-LaminA 10 00 256
Cytoplasm Texture Contrast DAPI 5 03 256
Cytoplasm Texture Correlation mEGFP-LaminA 20 01 256
Cytoplasm Intensity MADIntensity DAPI
Cytoplasm Texture DifferenceEntropy DAPI 5 03 256
NucleiExpanded RadialDistribution FracAtD DAPI 7of10
NuclearBoundary Intensity MassDisplacement DAPI
NucleiExpanded Texture SumVariance DAPI 10 01 256
Cytoplasm Texture SumEntropy DAPI 10 01 256
NuclearInterior Intensity MeanIntensity mEGFP-LaminA
Cytoplasm RadialDistribution MeanFrac mEGFP-LaminA 7of10
NucleiExpanded Intensity StdIntensity DAPI
Cytoplasm Granularity 9 DAPI
NuclearInterior Correlation RWC DAPI mEGFP-LaminA
NucleiExpanded Correlation K mEGFP-LaminA DAPI
Nuclei AreaShape MeanRadius
Cytoplasm Texture SumAverage DAPI 20 00 256
NucleiExpanded Texture Entropy DAPI 10 03 256
Cytoplasm Intensity UpperQuartileIntensity Ph+WGA
Cytoplasm RadialDistribution RadialCV DAPI 5of10
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 10 03 256
Cytoplasm Texture DifferenceEntropy mEGFP-LaminA 20 02 256
Cytoplasm Intensity MeanIntensityEdge mEGFP-LaminA
NuclearBoundary Intensity IntegratedIntensityEdge mEGFP-LaminA
Intensity IntegratedIntensity DAPI
AreaShape MaxFeretDiameter
NucleiExpanded Texture DifferenceVariance DAPI 10 02 256
NucleiExpanded Texture Contrast DAPI 10 01 256
NucleiExpanded Texture Correlation DAPI 5 01 256
NucleiExpanded Texture SumAverage mEGFP-LaminA 5 03 256
Intensity MADIntensity DAPI
Cytoplasm RadialDistribution FracAtD DAPI 2of10
NucleiExpanded Correlation RWC DAPI mEGFP-LaminA
Cytoplasm Intensity MinIntensity Mito
NucleiExpanded Texture Entropy DAPI 10 01 256
NucleiExpanded Texture DifferenceVariance DAPI 5 00 256
AreaShape MajorAxisLength
Cytoplasm RadialDistribution MeanFrac Ph+WGA 5of5
Cytoplasm Intensity MADIntensity Mito
Cytoplasm Texture Variance DAPI 20 02 256
Cytoplasm Correlation Correlation DAPI mEGFP-LaminA
Cytoplasm Texture SumVariance mEGFP-LaminA 5 02 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-LaminA 20 00 256
NucleiExpanded RadialDistribution MeanFrac mEGFP-LaminA 1of10
NucleiExpanded Texture Contrast mEGFP-LaminA 20 02 256
Cytoplasm Texture InfoMeas2 DAPI 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 20 02 256
30
20
10
0
-9
-6
-3
0
3
6
9
Feature z-score
Feature: NucleiExpanded Intensity MeanIntensity mEGFP-LaminA
K260Q
E264N
E214V
Q184F
Q258E
E236K
V191T
N195Y
M187N
F237W
L248Y
I210N
K180A
E178S
Q184V
N273T
Q198D
L271D
A244T
E194G
I210F
E217V
N273H
A242P
R196C
Q251R
K261I
K208Y
D185P
L241E
R189E
L183H
A179A
Y211N
T224P
L263W
E228D
Q258P
T224F
A242G
V227F
A250M
L215M
I210H
Y259T
E213I
M200P
D254C
E257D
T199W
L226A
I229H
E217P
E194R
K233S
R190S
G232T
A250I
L215H
K201E
K233A
E203R
L263C
Q207A
M187S
N209P
K261K
L183C
Y267A
M187K
E213H
D185W
S268L
R196A
Q246C
R189T
R235T
R220Q
K270P
E238Y
D185E
L241V
K233I
E178H
L183N
K270S
G232N
R189A
Q207S
Q207F
A269M
L197C
R225Q
E213C
V191K
D205R
T218N
T266W
L197Y
R240I
L248H
L271T
Y259W
H252S
E217L
R221F
V227V
I210W
A193D
Q258W
E253V
E253S
D185R
K265H
E236P
Y259A
L271S
S239W
Q246F
E213S
S268W
A193W
A244A
Y259G
R190E
R216R
T218D
L271A
R221R
S239P
N209L
A179M
E264C
Q207P
E262I
G232S
K260C
I210D
E178E
K201N
E223N
Q258M
R190G
K201D
Y211D
R196K
F237L
S212Q
V256R
D192A
E257N
Q234H
L241G
S212W
T218G
N195K
A193V
N231R
H252M
T266R
G232L
Q255S
F237A
K180D
R220P
Q198H
K270F
E186E
R235H
M187Y
D205M
G232A
A242N
L241W
E236R
K181D
F206T
V256Y
R235S
D254V
T224S
F237E
E228A
E223W
E238I
E253I
K208R
E223V
N273G
L226Q
L197W
T218F
Q246N
E264E
D243Y
R240G
F237N
H252K
L226L
Q182P
L215L
Q234M
E202T
D230E
N195S
E228Y
N209D
Y267K
R189I
D254S
E217G
L188H
R196G
E262E
F237H
R189L
K180P
A242Q
D272E
K219S
V256H
E253A
R221W
S212L
Q182F
K201F
L197T
L215W
F206N
Q184W
K180R
L226Y
Y259M
A244Q
R225C
E264P
S239L
V191V
D205I
E228F
H252P
Q184T
A242W
E257Y
E228I
R221A
E264V
K180M
F237K
K261W
L226T
D205C
L183K
N231P
L188L
V227A
E186V
L204W
R235P
Y267H
E236C
E223I
K233T
F237I
Y259N
L197Q
Q182L
E202A
K261Q
Q251D
L248V
A250E
V227H
N231I
K260V
A193E
A179T
D230F
K270T
D185T
R235Q
L188E
D272D
D243N
E202P
R235G
T266S
E203P
D254Q
E194K
E228R
R220H
N195M
K233M
D243P
A250F
M187Q
E247P
E264M
V256E
L204I
A242C
E238Q
K201K
S239T
G232W
Q198W
T218H
E247T
T199R
E262F
Q251N
L241K
G232Y
M200W
R189F
L183R
E223L
R221I
A244K
A193N
K201C
K261A
E236N
H252A
Q207T
K260W
E213M
K201T
S268I
D272T
L188W
G232G
Q207W
L204K
S239K
K208K
R235C
Q246P
Y259E
K270E
M187E
R225D
R189P
K219I
I229Y
L197G
R235Y
E223F
K219A
E213Y
Q234S
K181T
K233L
D243G
L183F
L215I
A242T
D243I
K265I
K180L
R190D
L188Q
D230T
H222E
K260H
I210G
K233F
K270G
E194E
Q184A
L271V
E236L
Y267Q
R240H
E203D
E214N
G232M
A250H
E217D
R196E
L245M
T266Q
L215G
E186W
D192I
K260S
K181F
L241M
Q251Y
A242H
K219K
A250V
Y267S
T199T
L271L
L226E
N273W
E257F
R225G
M187L
E264I
Q255W
D192N
K233R
E253L
R220F
F237V
N209R
K181C
D192S
V227Q
E214Y
E257C
A269D
E247D
Q251H
E257H
D230I
D205L
E236G
E186N
E217Y
R196S
E194S
Q258A
D192W
K219H
S239R
M187H
Q246L
V256T
R216T
S212D
L263E
K208L
E223T
K201H
Q198V
Q182S
Q234W
E228T
M187P
E202K
K181E
Q184N
N195W
Q207D
L245H
D254T
Q234K
M200E
E264Y
R190C
Q258Y
S212K
M200C
A244R
T266G
A242E
T218Y
E217S
Q198I
Q258N
L215R
E178V
E178P
A250W
R216Q
Q251P
L241P
E257E
F237S
S239N
R220W
E238E
K270L
K219F
F206W
M200A
F206M
E262M
E217K
I210L
K260G
V191G
L204D
E213W
D243Q
K180W
E186S
Q251V
Q207L
Y211V
A242V
E217T
R190W
L215S
Q255G
M200G
V256Q
R220T
N195D
A244F
K219P
M187A
R189R
D254I
E217H
Q234F
S268Y
F206A
R196M
E194C
A269F
K261P
Y267Y
E213T
E262T
K201L
R225W
L188P
N209A
D230H
F206S
S268R
S212C
R216G
Y267I
E203G
K180Q
L245W
V256F
N273S
Y259S
E223S
A269A
E257S
Q207M
Q255A
N273E
A193Y
E262C
R220K
D205H
K260A
E238H
A179I
E217Q
R225Y
L241H
D243S
M187R
R190F
F206Q
L245Y
Q184E
A250N
D243T
E213E
N209F
K265N
Q182D
I210R
L183M
E213R
L263M
A244W
T224V
L263D
N195V
E213A
S268E
N231W
E217W
Q246H
I210S
N195A
D272H
E186F
N231E
R216M
L226V
D272W
Q255I
H252L
Q255V
D192P
Q207I
K265P
L197I
A179N
E202I
E223C
A179Q
I229A
R196Q
R196I
E253Y
E264A
K219E
K181Q
F237Y
D192K
R225A
Y259V
Q184S
D230K
L188N
E264S
D230Y
T218P
E214S
F206C
R190Q
Q258G
L248M
Q251T
E228L
V191Y
Q182E
F206V
L263L
D192Y
A244D
M187C
Q246D
K260T
L197E
Q198E
D272R
I210P
L271R
D192H
R221H
L245S
A250G
K233W
R216W
L245P
L183E
T224D
K208H
E264F
K260R
Q207V
A269H
D185G
V191F
R240S
N195T
K180H
M187F
E186P
R220V
Q182G
R221D
K180G
K219N
Q207H
R235D
E202Q
N231C
T199G
E203N
Y259L
R221Q
N195G
T218V
Y259C
M187V
L245F
D243K
L263Q
A179F
A250D
S268P
T224H
L215E
E178G
D205Q
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K260Q
K260Q
E264N
E264N
E214V
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Q184F
Q184F
Q258E
Q258E
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K261I
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M187S
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Q207F
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L197C
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R225Q
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V191K
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D205R
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T218N
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T266W
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R240I
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L271T
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K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
0
100
200
300
400
-20
-15
-10
-5
0
5
External link
K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
Q258E
Q258E
E236K
E236K
V191T
V191T
N195Y
N195Y
M187N
M187N
F237W
F237W
L248Y
L248Y
I210N
I210N
K180A
K180A
E178S
E178S
Q184V
Q184V
N273T
N273T
Q198D
Q198D
L271D
L271D
A244T
A244T
E194G
E194G
I210F
I210F
E217V
E217V
N273H
N273H
A242P
A242P
R196C
R196C
Q251R
Q251R
K261I
K261I
K208Y
K208Y
D185P
D185P
L241E
L241E
Y259fs
Y259fs
R189E
R189E
L183H
L183H
A179A
A179A
Y211N
Y211N
T224P
T224P
L263W
L263W
E228D
E228D
Q258P
Q258P
K260fs
K260fs
T224F
T224F
A242G
A242G
V227F
V227F
A250M
A250M
L215M
L215M
I210H
I210H
Y259T
Y259T
E213I
E213I
M200P
M200P
D254C
D254C
E257D
E257D
T199W
T199W
L226A
L226A
I229H
I229H
E217P
E217P
E194R
E194R
K233S
K233S
R190S
R190S
G232T
G232T
A250I
A250I
L215H
L215H
K201E
K201E
K233A
K233A
E203R
E203R
L263C
L263C
Q207A
Q207A
M187S
M187S
N209P
N209P
K261K
K261K
L183C
L183C
Y267A
Y267A
M187K
M187K
E213H
E213H
D185W
D185W
S268L
S268L
R196A
R196A
Q246C
Q246C
R189T
R189T
R235T
R235T
R220Q
R220Q
K270P
K270P
E238Y
E238Y
D185E
D185E
L241V
L241V
K233I
K233I
E178H
E178H
L183N
L183N
K270S
K270S
G232N
G232N
R189A
R189A
Q207S
Q207S
Q207F
Q207F
A269M
A269M
L197C
L197C
R225Q
R225Q
E213C
E213C
V191K
V191K
D205R
D205R
T218N
T218N
T266W
T266W
L197Y
L197Y
R240I
R240I
L248H
L248H
L271T
L271T
Y259W
Y259W
H252S
H252S
E217L
E217L
R221F
R221F
V227V
V227V
I210W
I210W
A193D
A193D
Q258W
Q258W
E253V
E253V
N209fs
N209fs
E253S
E253S
D185R
D185R
K265H
K265H
E236P
E236P
Y259A
Y259A
L271S
L271S
S239W
S239W
Q246F
Q246F
E213S
E213S
S268W
S268W
A193W
A193W
A244A
A244A
Y259G
Y259G
R190E
R190E
R216R
R216R
T218D
T218D
L271A
L271A
R221R
R221R
S239P
S239P
N209L
N209L
A179M
A179M
E264C
E264C
Q207P
Q207P
E262I
E262I
G232S
G232S
K260C
K260C
S507fs
S507fs
I210D
I210D
E178E
E178E
K201N
K201N
Q184fs
Q184fs
E223N
E223N
Q258M
Q258M
R190G
R190G
K201D
K201D
Y211D
Y211D
R196K
R196K
F237L
F237L
S212Q
S212Q
V256R
V256R
D192A
D192A
E257N
E257N
Q234H
Q234H
L241G
L241G
S212W
S212W
T218G
T218G
N195K
N195K
A193V
A193V
N231R
N231R
H252M
H252M
T266R
T266R
G232L
G232L
Q255S
Q255S
F237A
F237A
K180D
K180D
R220P
R220P
Q198H
Q198H
K270F
K270F
L271fs
L271fs
E186E
E186E
E223fs
E223fs
R235H
R235H
M187Y
M187Y
D205M
D205M
G232A
G232A
A242N
A242N
L241W
L241W
E236R
E236R
K181D
K181D
F206T
F206T
V256Y
V256Y
R235S
R235S
D254V
D254V
T224S
T224S
F237E
F237E
E228A
E228A
E223W
E223W
E238I
E238I
E253I
E253I
K208R
K208R
E223V
E223V
N273G
N273G
L226Q
L226Q
L197W
L197W
T218F
T218F
Q246N
Q246N
E264E
E264E
D243Y
D243Y
R240G
R240G
F237N
F237N
H252K
H252K
L226L
L226L
Q182P
Q182P
L215L
L215L
Q234M
Q234M
E202T
E202T
D230E
D230E
N195S
N195S
E228Y
E228Y
N209D
N209D
Y267K
Y267K
R189I
R189I
D254S
D254S
E217G
E217G
L188H
L188H
R196G
R196G
E262E
E262E
F237H
F237H
R189L
R189L
K180P
K180P
A242Q
A242Q
D272E
D272E
K219S
K219S
V256H
V256H
E253A
E253A
R221W
R221W
S212L
S212L
Q182F
Q182F
K201F
K201F
L197T
L197T
L215W
L215W
F206N
F206N
Q184W
Q184W
K180R
K180R
L226Y
L226Y
Y259M
Y259M
A244Q
A244Q
R225C
R225C
E264P
E264P
S239L
S239L
V191V
V191V
D205I
D205I
E228F
E228F
H252P
H252P
Q184T
Q184T
A242W
A242W
E257Y
E257Y
E228I
E228I
R221A
R221A
E264V
E264V
K180M
K180M
F237K
F237K
K261W
K261W
L226T
L226T
D205C
D205C
L183K
L183K
N231P
N231P
L188L
L188L
V227A
V227A
E186V
E186V
L204W
L204W
R235P
R235P
Y267H
Y267H
E236C
E236C
E223I
E223I
K233T
K233T
F237I
F237I
Y259N
Y259N
L197Q
L197Q
Q182L
Q182L
E202A
E202A
K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
1.0
10.0
100.0
-20
-15
-10
-5
0
5
Log scale
NucleiExpanded Intensity MeanIntensity mEGFP-LaminA
Per variant images
Variant Synonymous
Variant Frameshift
Feature: NuclearBoundary Intensity MeanIntensity mEGFP-LaminA
K260Q
E264N
E214V
Q184F
Q258E
E236K
V191T
N195Y
M187N
F237W
L248Y
I210N
K180A
E178S
Q184V
N273T
Q198D
L271D
A244T
E194G
I210F
E217V
N273H
A242P
R196C
Q251R
K261I
K208Y
D185P
L241E
R189E
L183H
A179A
Y211N
T224P
L263W
E228D
Q258P
T224F
A242G
V227F
A250M
L215M
I210H
Y259T
E213I
M200P
D254C
E257D
T199W
L226A
I229H
E217P
E194R
K233S
R190S
G232T
A250I
L215H
K201E
K233A
E203R
L263C
Q207A
M187S
N209P
K261K
L183C
Y267A
M187K
E213H
D185W
S268L
R196A
Q246C
R189T
R235T
R220Q
K270P
E238Y
D185E
L241V
K233I
E178H
L183N
K270S
G232N
R189A
Q207S
Q207F
A269M
L197C
R225Q
E213C
V191K
D205R
T218N
T266W
L197Y
R240I
L248H
L271T
Y259W
H252S
E217L
R221F
V227V
I210W
A193D
Q258W
E253V
E253S
D185R
K265H
E236P
Y259A
L271S
S239W
Q246F
E213S
S268W
A193W
A244A
Y259G
R190E
R216R
T218D
L271A
R221R
S239P
N209L
A179M
E264C
Q207P
E262I
G232S
K260C
I210D
E178E
K201N
E223N
Q258M
R190G
K201D
Y211D
R196K
F237L
S212Q
V256R
D192A
E257N
Q234H
L241G
S212W
T218G
N195K
A193V
N231R
H252M
T266R
G232L
Q255S
F237A
K180D
R220P
Q198H
K270F
E186E
R235H
M187Y
D205M
G232A
A242N
L241W
E236R
K181D
F206T
V256Y
R235S
D254V
T224S
F237E
E228A
E223W
E238I
E253I
K208R
E223V
N273G
L226Q
L197W
T218F
Q246N
E264E
D243Y
R240G
F237N
H252K
L226L
Q182P
L215L
Q234M
E202T
D230E
N195S
E228Y
N209D
Y267K
R189I
D254S
E217G
L188H
R196G
E262E
F237H
R189L
K180P
A242Q
D272E
K219S
V256H
E253A
R221W
S212L
Q182F
K201F
L197T
L215W
F206N
Q184W
K180R
L226Y
Y259M
A244Q
R225C
E264P
S239L
V191V
D205I
E228F
H252P
Q184T
A242W
E257Y
E228I
R221A
E264V
K180M
F237K
K261W
L226T
D205C
L183K
N231P
L188L
V227A
E186V
L204W
R235P
Y267H
E236C
E223I
K233T
F237I
Y259N
L197Q
Q182L
E202A
K261Q
Q251D
L248V
A250E
V227H
N231I
K260V
A193E
A179T
D230F
K270T
D185T
R235Q
L188E
D272D
D243N
E202P
R235G
T266S
E203P
D254Q
E194K
E228R
R220H
N195M
K233M
D243P
A250F
M187Q
E247P
E264M
V256E
L204I
A242C
E238Q
K201K
S239T
G232W
Q198W
T218H
E247T
T199R
E262F
Q251N
L241K
G232Y
M200W
R189F
L183R
E223L
R221I
A244K
A193N
K201C
K261A
E236N
H252A
Q207T
K260W
E213M
K201T
S268I
D272T
L188W
G232G
Q207W
L204K
S239K
K208K
R235C
Q246P
Y259E
K270E
M187E
R225D
R189P
K219I
I229Y
L197G
R235Y
E223F
K219A
E213Y
Q234S
K181T
K233L
D243G
L183F
L215I
A242T
D243I
K265I
K180L
R190D
L188Q
D230T
H222E
K260H
I210G
K233F
K270G
E194E
Q184A
L271V
E236L
Y267Q
R240H
E203D
E214N
G232M
A250H
E217D
R196E
L245M
T266Q
L215G
E186W
D192I
K260S
K181F
L241M
Q251Y
A242H
K219K
A250V
Y267S
T199T
L271L
L226E
N273W
E257F
R225G
M187L
E264I
Q255W
D192N
K233R
E253L
R220F
F237V
N209R
K181C
D192S
V227Q
E214Y
E257C
A269D
E247D
Q251H
E257H
D230I
D205L
E236G
E186N
E217Y
R196S
E194S
Q258A
D192W
K219H
S239R
M187H
Q246L
V256T
R216T
S212D
L263E
K208L
E223T
K201H
Q198V
Q182S
Q234W
E228T
M187P
E202K
K181E
Q184N
N195W
Q207D
L245H
D254T
Q234K
M200E
E264Y
R190C
Q258Y
S212K
M200C
A244R
T266G
A242E
T218Y
E217S
Q198I
Q258N
L215R
E178V
E178P
A250W
R216Q
Q251P
L241P
E257E
F237S
S239N
R220W
E238E
K270L
K219F
F206W
M200A
F206M
E262M
E217K
I210L
K260G
V191G
L204D
E213W
D243Q
K180W
E186S
Q251V
Q207L
Y211V
A242V
E217T
R190W
L215S
Q255G
M200G
V256Q
R220T
N195D
A244F
K219P
M187A
R189R
D254I
E217H
Q234F
S268Y
F206A
R196M
E194C
A269F
K261P
Y267Y
E213T
E262T
K201L
R225W
L188P
N209A
D230H
F206S
S268R
S212C
R216G
Y267I
E203G
K180Q
L245W
V256F
N273S
Y259S
E223S
A269A
E257S
Q207M
Q255A
N273E
A193Y
E262C
R220K
D205H
K260A
E238H
A179I
E217Q
R225Y
L241H
D243S
M187R
R190F
F206Q
L245Y
Q184E
A250N
D243T
E213E
N209F
K265N
Q182D
I210R
L183M
E213R
L263M
A244W
T224V
L263D
N195V
E213A
S268E
N231W
E217W
Q246H
I210S
N195A
D272H
E186F
N231E
R216M
L226V
D272W
Q255I
H252L
Q255V
D192P
Q207I
K265P
L197I
A179N
E202I
E223C
A179Q
I229A
R196Q
R196I
E253Y
E264A
K219E
K181Q
F237Y
D192K
R225A
Y259V
Q184S
D230K
L188N
E264S
D230Y
T218P
E214S
F206C
R190Q
Q258G
L248M
Q251T
E228L
V191Y
Q182E
F206V
L263L
D192Y
A244D
M187C
Q246D
K260T
L197E
Q198E
D272R
I210P
L271R
D192H
R221H
L245S
A250G
K233W
R216W
L245P
L183E
T224D
K208H
E264F
K260R
Q207V
A269H
D185G
V191F
R240S
N195T
K180H
M187F
E186P
R220V
Q182G
R221D
K180G
K219N
Q207H
R235D
E202Q
N231C
T199G
E203N
Y259L
R221Q
N195G
T218V
Y259C
M187V
L245F
D243K
L263Q
A179F
A250D
S268P
T224H
L215E
E178G
D205Q
L245V
D272G
K219D
G232P
D272K
K208S
E264H
E253D
K233Y
K181G
K208T
A242D
L183I
R190N
K201R
L241C
M187D
N195H
H222M
D243C
Q234L
E214Q
H222V
Q182K
K265S
V227K
R220D
L263S
E253P
A269G
K180I
T224Q
L188A
L263V
I229S
L263A
A242A
Q255N
L204M
K181N
D185K
S268C
S268S
A250K
K261M
L183L
N231M
Q184L
L263G
E253C
L248F
E194L
E186T
Q246V
E257T
Q246W
E238C
L204V
Q255H
L215C
V191I
E238S
Q207Q
Y211Q
V256C
E236V
Q184D
N231Q
E203K
S268F
E213F
S212R
K180C
Y211M
S239Q
E178L
E262R
Q258T
R225F
S212P
A193M
V256D
L241I
D272I
Y211G
R190H
L215F
A179W
E264D
A269S
A193G
T218I
M200H
L204S
K261H
L271M
D185I
R240A
E253W
D230V
H222D
K261L
K180E
T218K
Q198L
A269L
E203Q
N231H
A242F
Q255M
S212F
D243R
A250S
D185C
R225P
E223A
V191A
V227G
L248D
Y211A
R216K
E228G
A242K
E194I
T218E
D205K
Q182H
V227D
K181M
R240E
F206H
D192G
L204A
H222T
N231L
A193C
Y259D
L245L
R221N
L204L
L241Y
Q207G
K265R
H222L
S239D
T266V
L245C
Q198R
D254M
Q251E
L183G
K181H
Y267E
E247E
L226M
K233E
R220M
R235I
K233P
R240L
S239E
D272N
I229I
D192C
S239M
K261E
L204H
Q255T
Y211K
E228S
L188S
E178W
S239A
L188R
A193Q
S239V
Y259F
Y211T
E213D
K219L
R190V
A244S
Y267F
D230D
H252D
E202S
L204P
N231D
R190M
Q234V
E194W
D230C
R190K
K180K
E238T
L215V
Q234A
L245E
E186D
E194Q
I210Y
R235L
L271Q
K181V
L183S
Y259P
E257R
L263R
E202E
H252C
K260I
R190I
D192F
E238F
E186M
K181W
R189K
F206K
H252F
A193A
K219T
E257G
K260Y
E213K
R240D
L226N
K265L
E264G
D205A
L226C
L248K
H222S
R240V
N273M
N273Y
L197P
L226I
R225N
S268G
I229C
L188G
E202N
T224G
R189D
Q184K
K181S
E202D
M200Q
N195F
Q207R
H222P
G232K
D272A
L245G
A250Q
L263T
E214T
D254H
R189Y
E253E
Q184R
K219Q
D205P
L188C
L271C
T224L
E214L
I229R
T199Q
L188D
Y211F
I210A
K208W
Q246Q
T266P
G232Q
Q251K
K233H
D272V
Y267D
N231G
D230Q
V256V
D254L
K270N
E178N
Q234P
R240Y
E194N
I229L
F237C
Q251I
Y267R
E213L
A179D
T224E
M200D
F237G
L226K
G232H
L245R
K265V
L215Y
R220G
K233N
Y267L
V227S
R225I
K270I
Q255L
L197K
Q258H
H252G
E186G
R216N
L271K
L183W
R235A
T218C
K265W
R216L
L215K
S239H
K233Q
T218L
F237T
D205G
R240P
R216E
E238L
T218M
D205F
L197M
F237R
N273D
D205W
M200I
E228H
A179S
D192R
D205Y
Q207N
L188K
E178R
N273R
E236I
E257K
E223M
A244I
N273I
A179H
E186I
Q258K
E223E
A193L
A179L
K208C
Q182Q
E178K
E264T
Q255Q
E238G
A179E
Q234E
R221S
L241T
L271P
G232R
N273P
A193H
D192M
F237F
E253T
E228P
D192D
Q182T
R189S
L263F
H222A
H222Y
Q234C
E178Q
V227E
E253R
A244L
N209G
Y267C
Q255Y
E238N
Y211R
M200F
T199D
D205E
S239Y
K265C
V256I
A250P
A179G
E203V
L271H
E213N
A244Y
S212Y
S268D
E214R
S268Q
Y211I
E223Y
T224N
D205V
S268V
A269C
V256M
R235R
V191E
N209H
H222R
K181I
E238A
K261F
A242L
Q234Y
D185F
M200T
E186R
Y267V
L248N
V256P
E214M
E214D
L245D
L248Q
L226R
K265T
Q198K
E213V
A269E
R225K
R216Y
L215D
K260N
L226W
L263I
S212I
M200Y
R240K
E262Q
N231Y
K180F
S268K
Q251W
Q184M
R240C
E262K
R190T
D254F
H252W
N195R
D205N
L263H
R225R
T199A
E214G
L245K
V227M
E213P
D254E
T218A
D243F
D185A
V256W
K261S
L204Y
E257Q
D185D
A179R
Q251F
K201A
N273C
T218R
H222I
T224M
E214H
N273L
K265M
T218Q
L248L
Q234R
G232E
E253M
E238W
L263N
D205D
D185S
L215T
S239C
K260P
Q198M
D230L
E238P
A244E
L188F
Y267W
Y211H
Q207K
E236Q
E257I
E217C
D230W
Y267P
N209T
N195E
L197A
Y211S
Q182M
Q184Q
Q198G
V256K
L188I
T218S
V227R
Q255R
R189M
Q182N
T224R
R225V
D230A
T224A
Q184H
Q246E
L248I
V227N
L245T
G232I
H252R
K260E
R240R
E257V
E178C
V191S
L215N
A193T
I229P
H222C
E202W
E194Y
H222Q
Q184G
E203H
D272S
N273Q
F206P
D185L
Q182A
D205T
K270V
R216I
L197V
Q251G
K265D
E228Q
E236E
E223Q
Q251A
Y267G
V191L
K261C
S239G
Y259R
E186H
H252N
E178D
N273F
R221T
L245N
K181A
A179K
V256N
N209K
R235M
Q258C
N209W
E262A
H252Q
Q198S
L183P
L241Q
D272F
D185Q
E213G
V191P
R225E
E217M
R235W
E214A
I210E
A269Y
D230R
E194H
E186K
K261V
N273N
R220S
I229K
D230S
K219R
Q246Y
L226F
Y211W
R196W
T266M
E238R
I229T
H252Y
E186C
V256G
L215A
E228C
E194F
Q182C
A193I
R190Y
K181K
R221G
E217I
L241S
A242Y
R240T
A244P
E223D
V191R
L204N
D243M
G232C
D205S
V227T
R240N
L183T
E236T
Q246K
S212N
K201M
F206R
L204R
H252V
A269K
K180N
Q255K
R240W
R189W
R240Q
R221K
D272Q
Q246S
S268H
A179P
K260D
G232V
Q234N
K261D
Q184C
L271F
E214P
Q258S
H252H
R216S
D254P
L215P
A250L
K219Y
E194D
E264R
A250R
H252T
R220E
E236F
E264Q
Q198T
E194V
I210I
Q246R
L183Q
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K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
Q258E
Q258E
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A242P
R196C
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Q251R
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K261I
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D185P
D185P
L241E
L241E
Y259fs
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R189E
R189E
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L183H
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A179A
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Q258P
K260fs
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A242G
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V227F
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A250M
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L241V
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A269M
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T218N
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A179M
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Q207P
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E262I
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G232S
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K260C
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S507fs
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I210D
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E178E
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K201N
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Q184fs
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E223N
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Q258M
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R190G
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K201D
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R196K
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S212Q
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L226Q
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L197W
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T218F
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D243Y
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F237N
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H252K
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M187Q
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L204I
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L183R
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H252A
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L188Q
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H222E
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K260H
K260H
I210G
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K233F
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K270G
K270G
E194E
E194E
Q184A
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M200fs
M200fs
E238fs
E238fs
L271V
L271V
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Y267Q
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R240H
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E203D
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E186W
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D192I
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K260S
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L241M
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F237fs
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L271L
L271L
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N273W
N273W
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R225G
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A269D
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D230I
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E236G
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E186N
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R196S
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E194S
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Q258A
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D192W
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S239R
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M187H
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S212D
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L263E
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K265P
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E264A
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K181Q
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D192K
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R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
0
100
200
300
-15
-10
-5
0
5
External link
K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
Q258E
Q258E
E236K
E236K
V191T
V191T
N195Y
N195Y
M187N
M187N
F237W
F237W
L248Y
L248Y
I210N
I210N
K180A
K180A
E178S
E178S
Q184V
Q184V
N273T
N273T
Q198D
Q198D
L271D
L271D
A244T
A244T
E194G
E194G
I210F
I210F
E217V
E217V
N273H
N273H
A242P
A242P
R196C
R196C
Q251R
Q251R
K261I
K261I
K208Y
K208Y
D185P
D185P
L241E
L241E
Y259fs
Y259fs
R189E
R189E
L183H
L183H
A179A
A179A
Y211N
Y211N
T224P
T224P
L263W
L263W
E228D
E228D
Q258P
Q258P
K260fs
K260fs
T224F
T224F
A242G
A242G
V227F
V227F
A250M
A250M
L215M
L215M
I210H
I210H
Y259T
Y259T
E213I
E213I
M200P
M200P
D254C
D254C
E257D
E257D
T199W
T199W
L226A
L226A
I229H
I229H
E217P
E217P
E194R
E194R
K233S
K233S
R190S
R190S
G232T
G232T
A250I
A250I
L215H
L215H
K201E
K201E
K233A
K233A
E203R
E203R
L263C
L263C
Q207A
Q207A
M187S
M187S
N209P
N209P
K261K
K261K
L183C
L183C
Y267A
Y267A
M187K
M187K
E213H
E213H
D185W
D185W
S268L
S268L
R196A
R196A
Q246C
Q246C
R189T
R189T
R235T
R235T
R220Q
R220Q
K270P
K270P
E238Y
E238Y
D185E
D185E
L241V
L241V
K233I
K233I
E178H
E178H
L183N
L183N
K270S
K270S
G232N
G232N
R189A
R189A
Q207S
Q207S
Q207F
Q207F
A269M
A269M
L197C
L197C
R225Q
R225Q
E213C
E213C
V191K
V191K
D205R
D205R
T218N
T218N
T266W
T266W
L197Y
L197Y
R240I
R240I
L248H
L248H
L271T
L271T
Y259W
Y259W
H252S
H252S
E217L
E217L
R221F
R221F
V227V
V227V
I210W
I210W
A193D
A193D
Q258W
Q258W
E253V
E253V
N209fs
N209fs
E253S
E253S
D185R
D185R
K265H
K265H
E236P
E236P
Y259A
Y259A
L271S
L271S
S239W
S239W
Q246F
Q246F
E213S
E213S
S268W
S268W
A193W
A193W
A244A
A244A
Y259G
Y259G
R190E
R190E
R216R
R216R
T218D
T218D
L271A
L271A
R221R
R221R
S239P
S239P
N209L
N209L
A179M
A179M
E264C
E264C
Q207P
Q207P
E262I
E262I
G232S
G232S
K260C
K260C
S507fs
S507fs
I210D
I210D
E178E
E178E
K201N
K201N
Q184fs
Q184fs
E223N
E223N
Q258M
Q258M
R190G
R190G
K201D
K201D
Y211D
Y211D
R196K
R196K
F237L
F237L
S212Q
S212Q
V256R
V256R
D192A
D192A
E257N
E257N
Q234H
Q234H
L241G
L241G
S212W
S212W
T218G
T218G
N195K
N195K
A193V
A193V
N231R
N231R
H252M
H252M
T266R
T266R
G232L
G232L
Q255S
Q255S
F237A
F237A
K180D
K180D
R220P
R220P
Q198H
Q198H
K270F
K270F
L271fs
L271fs
E186E
E186E
E223fs
E223fs
R235H
R235H
M187Y
M187Y
D205M
D205M
G232A
G232A
A242N
A242N
L241W
L241W
E236R
E236R
K181D
K181D
F206T
F206T
V256Y
V256Y
R235S
R235S
D254V
D254V
T224S
T224S
F237E
F237E
E228A
E228A
E223W
E223W
E238I
E238I
E253I
E253I
K208R
K208R
E223V
E223V
N273G
N273G
L226Q
L226Q
L197W
L197W
T218F
T218F
Q246N
Q246N
E264E
E264E
D243Y
D243Y
R240G
R240G
F237N
F237N
H252K
H252K
L226L
L226L
Q182P
Q182P
L215L
L215L
Q234M
Q234M
E202T
E202T
D230E
D230E
N195S
N195S
E228Y
E228Y
N209D
N209D
Y267K
Y267K
R189I
R189I
D254S
D254S
E217G
E217G
L188H
L188H
R196G
R196G
E262E
E262E
F237H
F237H
R189L
R189L
K180P
K180P
A242Q
A242Q
D272E
D272E
K219S
K219S
V256H
V256H
E253A
E253A
R221W
R221W
S212L
S212L
Q182F
Q182F
K201F
K201F
L197T
L197T
L215W
L215W
F206N
F206N
Q184W
Q184W
K180R
K180R
L226Y
L226Y
Y259M
Y259M
A244Q
A244Q
R225C
R225C
E264P
E264P
S239L
S239L
V191V
V191V
D205I
D205I
E228F
E228F
H252P
H252P
Q184T
Q184T
A242W
A242W
E257Y
E257Y
E228I
E228I
R221A
R221A
E264V
E264V
K180M
K180M
F237K
F237K
K261W
K261W
L226T
L226T
D205C
D205C
L183K
L183K
N231P
N231P
L188L
L188L
V227A
V227A
E186V
E186V
L204W
L204W
R235P
R235P
Y267H
Y267H
E236C
E236C
E223I
E223I
K233T
K233T
F237I
F237I
Y259N
Y259N
L197Q
L197Q
Q182L
Q182L
E202A
E202A
K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
1.0
10.0
100.0
-15
-10
-5
0
5
Log scale
NuclearBoundary Intensity MeanIntensity mEGFP-LaminA
Per variant images
Variant Synonymous
Variant Frameshift
Feature: NucleiExpanded Granularity 1 mEGFP-LaminA
K260Q
E264N
E214V
Q184F
Q258E
E236K
V191T
N195Y
M187N
F237W
L248Y
I210N
K180A
E178S
Q184V
N273T
Q198D
L271D
A244T
E194G
I210F
E217V
N273H
A242P
R196C
Q251R
K261I
K208Y
D185P
L241E
R189E
L183H
A179A
Y211N
T224P
L263W
E228D
Q258P
T224F
A242G
V227F
A250M
L215M
I210H
Y259T
E213I
M200P
D254C
E257D
T199W
L226A
I229H
E217P
E194R
K233S
R190S
G232T
A250I
L215H
K201E
K233A
E203R
L263C
Q207A
M187S
N209P
K261K
L183C
Y267A
M187K
E213H
D185W
S268L
R196A
Q246C
R189T
R235T
R220Q
K270P
E238Y
D185E
L241V
K233I
E178H
L183N
K270S
G232N
R189A
Q207S
Q207F
A269M
L197C
R225Q
E213C
V191K
D205R
T218N
T266W
L197Y
R240I
L248H
L271T
Y259W
H252S
E217L
R221F
V227V
I210W
A193D
Q258W
E253V
E253S
D185R
K265H
E236P
Y259A
L271S
S239W
Q246F
E213S
S268W
A193W
A244A
Y259G
R190E
R216R
T218D
L271A
R221R
S239P
N209L
A179M
E264C
Q207P
E262I
G232S
K260C
I210D
E178E
K201N
E223N
Q258M
R190G
K201D
Y211D
R196K
F237L
S212Q
V256R
D192A
E257N
Q234H
L241G
S212W
T218G
N195K
A193V
N231R
H252M
T266R
G232L
Q255S
F237A
K180D
R220P
Q198H
K270F
E186E
R235H
M187Y
D205M
G232A
A242N
L241W
E236R
K181D
F206T
V256Y
R235S
D254V
T224S
F237E
E228A
E223W
E238I
E253I
K208R
E223V
N273G
L226Q
L197W
T218F
Q246N
E264E
D243Y
R240G
F237N
H252K
L226L
Q182P
L215L
Q234M
E202T
D230E
N195S
E228Y
N209D
Y267K
R189I
D254S
E217G
L188H
R196G
E262E
F237H
R189L
K180P
A242Q
D272E
K219S
V256H
E253A
R221W
S212L
Q182F
K201F
L197T
L215W
F206N
Q184W
K180R
L226Y
Y259M
A244Q
R225C
E264P
S239L
V191V
D205I
E228F
H252P
Q184T
A242W
E257Y
E228I
R221A
E264V
K180M
F237K
K261W
L226T
D205C
L183K
N231P
L188L
V227A
E186V
L204W
R235P
Y267H
E236C
E223I
K233T
F237I
Y259N
L197Q
Q182L
E202A
K261Q
Q251D
L248V
A250E
V227H
N231I
K260V
A193E
A179T
D230F
K270T
D185T
R235Q
L188E
D272D
D243N
E202P
R235G
T266S
E203P
D254Q
E194K
E228R
R220H
N195M
K233M
D243P
A250F
M187Q
E247P
E264M
V256E
L204I
A242C
E238Q
K201K
S239T
G232W
Q198W
T218H
E247T
T199R
E262F
Q251N
L241K
G232Y
M200W
R189F
L183R
E223L
R221I
A244K
A193N
K201C
K261A
E236N
H252A
Q207T
K260W
E213M
K201T
S268I
D272T
L188W
G232G
Q207W
L204K
S239K
K208K
R235C
Q246P
Y259E
K270E
M187E
R225D
R189P
K219I
I229Y
L197G
R235Y
E223F
K219A
E213Y
Q234S
K181T
K233L
D243G
L183F
L215I
A242T
D243I
K265I
K180L
R190D
L188Q
D230T
H222E
K260H
I210G
K233F
K270G
E194E
Q184A
L271V
E236L
Y267Q
R240H
E203D
E214N
G232M
A250H
E217D
R196E
L245M
T266Q
L215G
E186W
D192I
K260S
K181F
L241M
Q251Y
A242H
K219K
A250V
Y267S
T199T
L271L
L226E
N273W
E257F
R225G
M187L
E264I
Q255W
D192N
K233R
E253L
R220F
F237V
N209R
K181C
D192S
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K260Q
K260Q
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E214V
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N273H
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R196C
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Q251R
Q251R
K261I
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K208Y
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D185P
D185P
L241E
L241E
Y259fs
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R189E
R189E
L183H
L183H
A179A
A179A
Y211N
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T224P
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L263W
L263W
E228D
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Q258P
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K260fs
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T224F
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A242G
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A250M
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G232N
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R189A
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Q207S
Q207F
Q207F
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A269M
L197C
L197C
R225Q
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V191K
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D205R
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T218N
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T266W
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S507fs
S507fs
I210D
I210D
E178E
E178E
K201N
K201N
Q184fs
Q184fs
E223N
E223N
Q258M
Q258M
R190G
R190G
K201D
K201D
Y211D
Y211D
R196K
R196K
F237L
F237L
S212Q
S212Q
V256R
V256R
D192A
D192A
E257N
E257N
Q234H
Q234H
L241G
L241G
S212W
S212W
T218G
T218G
N195K
N195K
A193V
A193V
N231R
N231R
H252M
H252M
T266R
T266R
G232L
G232L
Q255S
Q255S
F237A
F237A
K180D
K180D
R220P
R220P
Q198H
Q198H
K270F
K270F
L271fs
L271fs
E186E
E186E
E223fs
E223fs
R235H
R235H
M187Y
M187Y
D205M
D205M
G232A
G232A
A242N
A242N
L241W
L241W
E236R
E236R
K181D
K181D
F206T
F206T
V256Y
V256Y
R235S
R235S
D254V
D254V
T224S
T224S
F237E
F237E
E228A
E228A
E223W
E223W
E238I
E238I
E253I
E253I
K208R
K208R
E223V
E223V
N273G
N273G
L226Q
L226Q
L197W
L197W
T218F
T218F
Q246N
Q246N
E264E
E264E
D243Y
D243Y
R240G
R240G
F237N
F237N
H252K
H252K
L226L
L226L
Q182P
Q182P
L215L
L215L
Q234M
Q234M
E202T
E202T
D230E
D230E
N195S
N195S
E228Y
E228Y
N209D
N209D
Y267K
Y267K
R189I
R189I
D254S
D254S
E217G
E217G
L188H
L188H
R196G
R196G
E262E
E262E
F237H
F237H
R189L
R189L
K180P
K180P
A242Q
A242Q
D272E
D272E
K219S
K219S
V256H
V256H
E253A
E253A
R221W
R221W
S212L
S212L
Q182F
Q182F
K201F
K201F
L197T
L197T
L215W
L215W
F206N
F206N
Q184W
Q184W
K180R
K180R
L226Y
L226Y
Y259M
Y259M
A244Q
A244Q
R225C
R225C
E264P
E264P
S239L
S239L
V191V
V191V
D205I
D205I
E228F
E228F
H252P
H252P
Q184T
Q184T
A242W
A242W
E257Y
E257Y
E228I
E228I
R221A
R221A
E264V
E264V
K180M
K180M
F237K
F237K
K261W
K261W
L226T
L226T
D205C
D205C
L183K
L183K
N231P
N231P
L188L
L188L
V227A
V227A
E186V
E186V
L204W
L204W
R235P
R235P
Y267H
Y267H
E236C
E236C
E223I
E223I
K233T
K233T
F237I
F237I
Y259N
Y259N
L197Q
L197Q
Q182L
Q182L
E202A
E202A
K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
0
200
400
600
0
20
40
60
80
100
External link
K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
Q258E
Q258E
E236K
E236K
V191T
V191T
N195Y
N195Y
M187N
M187N
F237W
F237W
L248Y
L248Y
I210N
I210N
K180A
K180A
E178S
E178S
Q184V
Q184V
N273T
N273T
Q198D
Q198D
L271D
L271D
A244T
A244T
E194G
E194G
I210F
I210F
E217V
E217V
N273H
N273H
A242P
A242P
R196C
R196C
Q251R
Q251R
K261I
K261I
K208Y
K208Y
D185P
D185P
L241E
L241E
Y259fs
Y259fs
R189E
R189E
L183H
L183H
A179A
A179A
Y211N
Y211N
T224P
T224P
L263W
L263W
E228D
E228D
Q258P
Q258P
K260fs
K260fs
T224F
T224F
A242G
A242G
V227F
V227F
A250M
A250M
L215M
L215M
I210H
I210H
Y259T
Y259T
E213I
E213I
M200P
M200P
D254C
D254C
E257D
E257D
T199W
T199W
L226A
L226A
I229H
I229H
E217P
E217P
E194R
E194R
K233S
K233S
R190S
R190S
G232T
G232T
A250I
A250I
L215H
L215H
K201E
K201E
K233A
K233A
E203R
E203R
L263C
L263C
Q207A
Q207A
M187S
M187S
N209P
N209P
K261K
K261K
L183C
L183C
Y267A
Y267A
M187K
M187K
E213H
E213H
D185W
D185W
S268L
S268L
R196A
R196A
Q246C
Q246C
R189T
R189T
R235T
R235T
R220Q
R220Q
K270P
K270P
E238Y
E238Y
D185E
D185E
L241V
L241V
K233I
K233I
E178H
E178H
L183N
L183N
K270S
K270S
G232N
G232N
R189A
R189A
Q207S
Q207S
Q207F
Q207F
A269M
A269M
L197C
L197C
R225Q
R225Q
E213C
E213C
V191K
V191K
D205R
D205R
T218N
T218N
T266W
T266W
L197Y
L197Y
R240I
R240I
L248H
L248H
L271T
L271T
Y259W
Y259W
H252S
H252S
E217L
E217L
R221F
R221F
V227V
V227V
I210W
I210W
A193D
A193D
Q258W
Q258W
E253V
E253V
N209fs
N209fs
E253S
E253S
D185R
D185R
K265H
K265H
E236P
E236P
Y259A
Y259A
L271S
L271S
S239W
S239W
Q246F
Q246F
E213S
E213S
S268W
S268W
A193W
A193W
A244A
A244A
Y259G
Y259G
R190E
R190E
R216R
R216R
T218D
T218D
L271A
L271A
R221R
R221R
S239P
S239P
N209L
N209L
A179M
A179M
E264C
E264C
Q207P
Q207P
E262I
E262I
G232S
G232S
K260C
K260C
S507fs
S507fs
I210D
I210D
E178E
E178E
K201N
K201N
Q184fs
Q184fs
E223N
E223N
Q258M
Q258M
R190G
R190G
K201D
K201D
Y211D
Y211D
R196K
R196K
F237L
F237L
S212Q
S212Q
V256R
V256R
D192A
D192A
E257N
E257N
Q234H
Q234H
L241G
L241G
S212W
S212W
T218G
T218G
N195K
N195K
A193V
A193V
N231R
N231R
H252M
H252M
T266R
T266R
G232L
G232L
Q255S
Q255S
F237A
F237A
K180D
K180D
R220P
R220P
Q198H
Q198H
K270F
K270F
L271fs
L271fs
E186E
E186E
E223fs
E223fs
R235H
R235H
M187Y
M187Y
D205M
D205M
G232A
G232A
A242N
A242N
L241W
L241W
E236R
E236R
K181D
K181D
F206T
F206T
V256Y
V256Y
R235S
R235S
D254V
D254V
T224S
T224S
F237E
F237E
E228A
E228A
E223W
E223W
E238I
E238I
E253I
E253I
K208R
K208R
E223V
E223V
N273G
N273G
L226Q
L226Q
L197W
L197W
T218F
T218F
Q246N
Q246N
E264E
E264E
D243Y
D243Y
R240G
R240G
F237N
F237N
H252K
H252K
L226L
L226L
Q182P
Q182P
L215L
L215L
Q234M
Q234M
E202T
E202T
D230E
D230E
N195S
N195S
E228Y
E228Y
N209D
N209D
Y267K
Y267K
R189I
R189I
D254S
D254S
E217G
E217G
L188H
L188H
R196G
R196G
E262E
E262E
F237H
F237H
R189L
R189L
K180P
K180P
A242Q
A242Q
D272E
D272E
K219S
K219S
V256H
V256H
E253A
E253A
R221W
R221W
S212L
S212L
Q182F
Q182F
K201F
K201F
L197T
L197T
L215W
L215W
F206N
F206N
Q184W
Q184W
K180R
K180R
L226Y
L226Y
Y259M
Y259M
A244Q
A244Q
R225C
R225C
E264P
E264P
S239L
S239L
V191V
V191V
D205I
D205I
E228F
E228F
H252P
H252P
Q184T
Q184T
A242W
A242W
E257Y
E257Y
E228I
E228I
R221A
R221A
E264V
E264V
K180M
K180M
F237K
F237K
K261W
K261W
L226T
L226T
D205C
D205C
L183K
L183K
N231P
N231P
L188L
L188L
V227A
V227A
E186V
E186V
L204W
L204W
R235P
R235P
Y267H
Y267H
E236C
E236C
E223I
E223I
K233T
K233T
F237I
F237I
Y259N
Y259N
L197Q
L197Q
Q182L
Q182L
E202A
E202A
K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
1.0
10.0
100.0
0
20
40
60
80
100
Log scale
NucleiExpanded Granularity 1 mEGFP-LaminA
Per variant images
Variant Synonymous
Variant Frameshift
Feature: Nuclei AreaShape FormFactor
K260Q
E264N
E214V
Q184F
Q258E
E236K
V191T
N195Y
M187N
F237W
L248Y
I210N
K180A
E178S
Q184V
N273T
Q198D
L271D
A244T
E194G
I210F
E217V
N273H
A242P
R196C
Q251R
K261I
K208Y
D185P
L241E
R189E
L183H
A179A
Y211N
T224P
L263W
E228D
Q258P
T224F
A242G
V227F
A250M
L215M
I210H
Y259T
E213I
M200P
D254C
E257D
T199W
L226A
I229H
E217P
E194R
K233S
R190S
G232T
A250I
L215H
K201E
K233A
E203R
L263C
Q207A
M187S
N209P
K261K
L183C
Y267A
M187K
E213H
D185W
S268L
R196A
Q246C
R189T
R235T
R220Q
K270P
E238Y
D185E
L241V
K233I
E178H
L183N
K270S
G232N
R189A
Q207S
Q207F
A269M
L197C
R225Q
E213C
V191K
D205R
T218N
T266W
L197Y
R240I
L248H
L271T
Y259W
H252S
E217L
R221F
V227V
I210W
A193D
Q258W
E253V
E253S
D185R
K265H
E236P
Y259A
L271S
S239W
Q246F
E213S
S268W
A193W
A244A
Y259G
R190E
R216R
T218D
L271A
R221R
S239P
N209L
A179M
E264C
Q207P
E262I
G232S
K260C
I210D
E178E
K201N
E223N
Q258M
R190G
K201D
Y211D
R196K
F237L
S212Q
V256R
D192A
E257N
Q234H
L241G
S212W
T218G
N195K
A193V
N231R
H252M
T266R
G232L
Q255S
F237A
K180D
R220P
Q198H
K270F
E186E
R235H
M187Y
D205M
G232A
A242N
L241W
E236R
K181D
F206T
V256Y
R235S
D254V
T224S
F237E
E228A
E223W
E238I
E253I
K208R
E223V
N273G
L226Q
L197W
T218F
Q246N
E264E
D243Y
R240G
F237N
H252K
L226L
Q182P
L215L
Q234M
E202T
D230E
N195S
E228Y
N209D
Y267K
R189I
D254S
E217G
L188H
R196G
E262E
F237H
R189L
K180P
A242Q
D272E
K219S
V256H
E253A
R221W
S212L
Q182F
K201F
L197T
L215W
F206N
Q184W
K180R
L226Y
Y259M
A244Q
R225C
E264P
S239L
V191V
D205I
E228F
H252P
Q184T
A242W
E257Y
E228I
R221A
E264V
K180M
F237K
K261W
L226T
D205C
L183K
N231P
L188L
V227A
E186V
L204W
R235P
Y267H
E236C
E223I
K233T
F237I
Y259N
L197Q
Q182L
E202A
K261Q
Q251D
L248V
A250E
V227H
N231I
K260V
A193E
A179T
D230F
K270T
D185T
R235Q
L188E
D272D
D243N
E202P
R235G
T266S
E203P
D254Q
E194K
E228R
R220H
N195M
K233M
D243P
A250F
M187Q
E247P
E264M
V256E
L204I
A242C
E238Q
K201K
S239T
G232W
Q198W
T218H
E247T
T199R
E262F
Q251N
L241K
G232Y
M200W
R189F
L183R
E223L
R221I
A244K
A193N
K201C
K261A
E236N
H252A
Q207T
K260W
E213M
K201T
S268I
D272T
L188W
G232G
Q207W
L204K
S239K
K208K
R235C
Q246P
Y259E
K270E
M187E
R225D
R189P
K219I
I229Y
L197G
R235Y
E223F
K219A
E213Y
Q234S
K181T
K233L
D243G
L183F
L215I
A242T
D243I
K265I
K180L
R190D
L188Q
D230T
H222E
K260H
I210G
K233F
K270G
E194E
Q184A
L271V
E236L
Y267Q
R240H
E203D
E214N
G232M
A250H
E217D
R196E
L245M
T266Q
L215G
E186W
D192I
K260S
K181F
L241M
Q251Y
A242H
K219K
A250V
Y267S
T199T
L271L
L226E
N273W
E257F
R225G
M187L
E264I
Q255W
D192N
K233R
E253L
R220F
F237V
N209R
K181C
D192S
V227Q
E214Y
E257C
A269D
E247D
Q251H
E257H
D230I
D205L
E236G
E186N
E217Y
R196S
E194S
Q258A
D192W
K219H
S239R
M187H
Q246L
V256T
R216T
S212D
L263E
K208L
E223T
K201H
Q198V
Q182S
Q234W
E228T
M187P
E202K
K181E
Q184N
N195W
Q207D
L245H
D254T
Q234K
M200E
E264Y
R190C
Q258Y
S212K
M200C
A244R
T266G
A242E
T218Y
E217S
Q198I
Q258N
L215R
E178V
E178P
A250W
R216Q
Q251P
L241P
E257E
F237S
S239N
R220W
E238E
K270L
K219F
F206W
M200A
F206M
E262M
E217K
I210L
K260G
V191G
L204D
E213W
D243Q
K180W
E186S
Q251V
Q207L
Y211V
A242V
E217T
R190W
L215S
Q255G
M200G
V256Q
R220T
N195D
A244F
K219P
M187A
R189R
D254I
E217H
Q234F
S268Y
F206A
R196M
E194C
A269F
K261P
Y267Y
E213T
E262T
K201L
R225W
L188P
N209A
D230H
F206S
S268R
S212C
R216G
Y267I
E203G
K180Q
L245W
V256F
N273S
Y259S
E223S
A269A
E257S
Q207M
Q255A
N273E
A193Y
E262C
R220K
D205H
K260A
E238H
A179I
E217Q
R225Y
L241H
D243S
M187R
R190F
F206Q
L245Y
Q184E
A250N
D243T
E213E
N209F
K265N
Q182D
I210R
L183M
E213R
L263M
A244W
T224V
L263D
N195V
E213A
S268E
N231W
E217W
Q246H
I210S
N195A
D272H
E186F
N231E
R216M
L226V
D272W
Q255I
H252L
Q255V
D192P
Q207I
K265P
L197I
A179N
E202I
E223C
A179Q
I229A
R196Q
R196I
E253Y
E264A
K219E
K181Q
F237Y
D192K
R225A
Y259V
Q184S
D230K
L188N
E264S
D230Y
T218P
E214S
F206C
R190Q
Q258G
L248M
Q251T
E228L
V191Y
Q182E
F206V
L263L
D192Y
A244D
M187C
Q246D
K260T
L197E
Q198E
D272R
I210P
L271R
D192H
R221H
L245S
A250G
K233W
R216W
L245P
L183E
T224D
K208H
E264F
K260R
Q207V
A269H
D185G
V191F
R240S
N195T
K180H
M187F
E186P
R220V
Q182G
R221D
K180G
K219N
Q207H
R235D
E202Q
N231C
T199G
E203N
Y259L
R221Q
N195G
T218V
Y259C
M187V
L245F
D243K
L263Q
A179F
A250D
S268P
T224H
L215E
E178G
D205Q
L245V
D272G
K219D
G232P
D272K
K208S
E264H
E253D
K233Y
K181G
K208T
A242D
L183I
R190N
K201R
L241C
M187D
N195H
H222M
D243C
Q234L
E214Q
H222V
Q182K
K265S
V227K
R220D
L263S
E253P
A269G
K180I
T224Q
L188A
L263V
I229S
L263A
A242A
Q255N
L204M
K181N
D185K
S268C
S268S
A250K
K261M
L183L
N231M
Q184L
L263G
E253C
L248F
E194L
E186T
Q246V
E257T
Q246W
E238C
L204V
Q255H
L215C
V191I
E238S
Q207Q
Y211Q
V256C
E236V
Q184D
N231Q
E203K
S268F
E213F
S212R
K180C
Y211M
S239Q
E178L
E262R
Q258T
R225F
S212P
A193M
V256D
L241I
D272I
Y211G
R190H
L215F
A179W
E264D
A269S
A193G
T218I
M200H
L204S
K261H
L271M
D185I
R240A
E253W
D230V
H222D
K261L
K180E
T218K
Q198L
A269L
E203Q
N231H
A242F
Q255M
S212F
D243R
A250S
D185C
R225P
E223A
V191A
V227G
L248D
Y211A
R216K
E228G
A242K
E194I
T218E
D205K
Q182H
V227D
K181M
R240E
F206H
D192G
L204A
H222T
N231L
A193C
Y259D
L245L
R221N
L204L
L241Y
Q207G
K265R
H222L
S239D
T266V
L245C
Q198R
D254M
Q251E
L183G
K181H
Y267E
E247E
L226M
K233E
R220M
R235I
K233P
R240L
S239E
D272N
I229I
D192C
S239M
K261E
L204H
Q255T
Y211K
E228S
L188S
E178W
S239A
L188R
A193Q
S239V
Y259F
Y211T
E213D
K219L
R190V
A244S
Y267F
D230D
H252D
E202S
L204P
N231D
R190M
Q234V
E194W
D230C
R190K
K180K
E238T
L215V
Q234A
L245E
E186D
E194Q
I210Y
R235L
L271Q
K181V
L183S
Y259P
E257R
L263R
E202E
H252C
K260I
R190I
D192F
E238F
E186M
K181W
R189K
F206K
H252F
A193A
K219T
E257G
K260Y
E213K
R240D
L226N
K265L
E264G
D205A
L226C
L248K
H222S
R240V
N273M
N273Y
L197P
L226I
R225N
S268G
I229C
L188G
E202N
T224G
R189D
Q184K
K181S
E202D
M200Q
N195F
Q207R
H222P
G232K
D272A
L245G
A250Q
L263T
E214T
D254H
R189Y
E253E
Q184R
K219Q
D205P
L188C
L271C
T224L
E214L
I229R
T199Q
L188D
Y211F
I210A
K208W
Q246Q
T266P
G232Q
Q251K
K233H
D272V
Y267D
N231G
D230Q
V256V
D254L
K270N
E178N
Q234P
R240Y
E194N
I229L
F237C
Q251I
Y267R
E213L
A179D
T224E
M200D
F237G
L226K
G232H
L245R
K265V
L215Y
R220G
K233N
Y267L
V227S
R225I
K270I
Q255L
L197K
Q258H
H252G
E186G
R216N
L271K
L183W
R235A
T218C
K265W
R216L
L215K
S239H
K233Q
T218L
F237T
D205G
R240P
R216E
E238L
T218M
D205F
L197M
F237R
N273D
D205W
M200I
E228H
A179S
D192R
D205Y
Q207N
L188K
E178R
N273R
E236I
E257K
E223M
A244I
N273I
A179H
E186I
Q258K
E223E
A193L
A179L
K208C
Q182Q
E178K
E264T
Q255Q
E238G
A179E
Q234E
R221S
L241T
L271P
G232R
N273P
A193H
D192M
F237F
E253T
E228P
D192D
Q182T
R189S
L263F
H222A
H222Y
Q234C
E178Q
V227E
E253R
A244L
N209G
Y267C
Q255Y
E238N
Y211R
M200F
T199D
D205E
S239Y
K265C
V256I
A250P
A179G
E203V
L271H
E213N
A244Y
S212Y
S268D
E214R
S268Q
Y211I
E223Y
T224N
D205V
S268V
A269C
V256M
R235R
V191E
N209H
H222R
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K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
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Q258E
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L241E
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Y259fs
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Y211N
T224P
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K260fs
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V227F
V227F
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A250M
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R189A
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A269M
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N209fs
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A179M
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S507fs
S507fs
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K201N
K201N
Q184fs
Q184fs
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E223N
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Q258M
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K201D
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A242N
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L226Q
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Q246N
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F237N
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M200fs
M200fs
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L271V
L271V
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N273W
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M187L
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K233R
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N209R
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K181C
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V227Q
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A269D
A269D
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D230I
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D205L
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R196S
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Q258A
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S239R
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M187H
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L263E
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E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
0
50
100
150
200
-12
-9
-6
-3
0
3
6
9
External link
K260Q
K260Q
E264N
E264N
E214V
E214V
Q184F
Q184F
Q258E
Q258E
E236K
E236K
V191T
V191T
N195Y
N195Y
M187N
M187N
F237W
F237W
L248Y
L248Y
I210N
I210N
K180A
K180A
E178S
E178S
Q184V
Q184V
N273T
N273T
Q198D
Q198D
L271D
L271D
A244T
A244T
E194G
E194G
I210F
I210F
E217V
E217V
N273H
N273H
A242P
A242P
R196C
R196C
Q251R
Q251R
K261I
K261I
K208Y
K208Y
D185P
D185P
L241E
L241E
Y259fs
Y259fs
R189E
R189E
L183H
L183H
A179A
A179A
Y211N
Y211N
T224P
T224P
L263W
L263W
E228D
E228D
Q258P
Q258P
K260fs
K260fs
T224F
T224F
A242G
A242G
V227F
V227F
A250M
A250M
L215M
L215M
I210H
I210H
Y259T
Y259T
E213I
E213I
M200P
M200P
D254C
D254C
E257D
E257D
T199W
T199W
L226A
L226A
I229H
I229H
E217P
E217P
E194R
E194R
K233S
K233S
R190S
R190S
G232T
G232T
A250I
A250I
L215H
L215H
K201E
K201E
K233A
K233A
E203R
E203R
L263C
L263C
Q207A
Q207A
M187S
M187S
N209P
N209P
K261K
K261K
L183C
L183C
Y267A
Y267A
M187K
M187K
E213H
E213H
D185W
D185W
S268L
S268L
R196A
R196A
Q246C
Q246C
R189T
R189T
R235T
R235T
R220Q
R220Q
K270P
K270P
E238Y
E238Y
D185E
D185E
L241V
L241V
K233I
K233I
E178H
E178H
L183N
L183N
K270S
K270S
G232N
G232N
R189A
R189A
Q207S
Q207S
Q207F
Q207F
A269M
A269M
L197C
L197C
R225Q
R225Q
E213C
E213C
V191K
V191K
D205R
D205R
T218N
T218N
T266W
T266W
L197Y
L197Y
R240I
R240I
L248H
L248H
L271T
L271T
Y259W
Y259W
H252S
H252S
E217L
E217L
R221F
R221F
V227V
V227V
I210W
I210W
A193D
A193D
Q258W
Q258W
E253V
E253V
N209fs
N209fs
E253S
E253S
D185R
D185R
K265H
K265H
E236P
E236P
Y259A
Y259A
L271S
L271S
S239W
S239W
Q246F
Q246F
E213S
E213S
S268W
S268W
A193W
A193W
A244A
A244A
Y259G
Y259G
R190E
R190E
R216R
R216R
T218D
T218D
L271A
L271A
R221R
R221R
S239P
S239P
N209L
N209L
A179M
A179M
E264C
E264C
Q207P
Q207P
E262I
E262I
G232S
G232S
K260C
K260C
S507fs
S507fs
I210D
I210D
E178E
E178E
K201N
K201N
Q184fs
Q184fs
E223N
E223N
Q258M
Q258M
R190G
R190G
K201D
K201D
Y211D
Y211D
R196K
R196K
F237L
F237L
S212Q
S212Q
V256R
V256R
D192A
D192A
E257N
E257N
Q234H
Q234H
L241G
L241G
S212W
S212W
T218G
T218G
N195K
N195K
A193V
A193V
N231R
N231R
H252M
H252M
T266R
T266R
G232L
G232L
Q255S
Q255S
F237A
F237A
K180D
K180D
R220P
R220P
Q198H
Q198H
K270F
K270F
L271fs
L271fs
E186E
E186E
E223fs
E223fs
R235H
R235H
M187Y
M187Y
D205M
D205M
G232A
G232A
A242N
A242N
L241W
L241W
E236R
E236R
K181D
K181D
F206T
F206T
V256Y
V256Y
R235S
R235S
D254V
D254V
T224S
T224S
F237E
F237E
E228A
E228A
E223W
E223W
E238I
E238I
E253I
E253I
K208R
K208R
E223V
E223V
N273G
N273G
L226Q
L226Q
L197W
L197W
T218F
T218F
Q246N
Q246N
E264E
E264E
D243Y
D243Y
R240G
R240G
F237N
F237N
H252K
H252K
L226L
L226L
Q182P
Q182P
L215L
L215L
Q234M
Q234M
E202T
E202T
D230E
D230E
N195S
N195S
E228Y
E228Y
N209D
N209D
Y267K
Y267K
R189I
R189I
D254S
D254S
E217G
E217G
L188H
L188H
R196G
R196G
E262E
E262E
F237H
F237H
R189L
R189L
K180P
K180P
A242Q
A242Q
D272E
D272E
K219S
K219S
V256H
V256H
E253A
E253A
R221W
R221W
S212L
S212L
Q182F
Q182F
K201F
K201F
L197T
L197T
L215W
L215W
F206N
F206N
Q184W
Q184W
K180R
K180R
L226Y
L226Y
Y259M
Y259M
A244Q
A244Q
R225C
R225C
E264P
E264P
S239L
S239L
V191V
V191V
D205I
D205I
E228F
E228F
H252P
H252P
Q184T
Q184T
A242W
A242W
E257Y
E257Y
E228I
E228I
R221A
R221A
E264V
E264V
K180M
K180M
F237K
F237K
K261W
K261W
L226T
L226T
D205C
D205C
L183K
L183K
N231P
N231P
L188L
L188L
V227A
V227A
E186V
E186V
L204W
L204W
R235P
R235P
Y267H
Y267H
E236C
E236C
E223I
E223I
K233T
K233T
F237I
F237I
Y259N
Y259N
L197Q
L197Q
Q182L
Q182L
E202A
E202A
K261Q
K261Q
Q251D
Q251D
L248V
L248V
A250E
A250E
V227H
V227H
N231I
N231I
K260V
K260V
A193E
A193E
A179T
A179T
D230F
D230F
K270T
K270T
D185T
D185T
R235Q
R235Q
L188E
L188E
D272D
D272D
D243N
D243N
E202P
E202P
R235G
R235G
T266S
T266S
E203P
E203P
D254Q
D254Q
E194K
E194K
E228R
E228R
R220H
R220H
N195M
N195M
K233M
K233M
D243P
D243P
A250F
A250F
M187Q
M187Q
E247P
E247P
E264M
E264M
V256E
V256E
L204I
L204I
A242C
A242C
E238Q
E238Q
K201K
K201K
S239T
S239T
G232W
G232W
Q198W
Q198W
T218H
T218H
E247T
E247T
T199R
T199R
E262F
E262F
Q251N
Q251N
L241K
L241K
G232Y
G232Y
M200W
M200W
R189F
R189F
L183R
L183R
E223L
E223L
R221I
R221I
A244K
A244K
A193N
A193N
K201C
K201C
K261A
K261A
E236N
E236N
H252A
H252A
Q207T
Q207T
K260W
K260W
E213M
E213M
K201T
K201T
S268I
S268I
D272T
D272T
L188W
L188W
G232G
G232G
Q207W
Q207W
L204K
L204K
S239K
S239K
K208K
K208K
R235C
R235C
Q246P
Q246P
Y259E
Y259E
K270E
K270E
M187E
M187E
R225D
R225D
R189P
R189P
K219I
K219I
I229Y
I229Y
L197G
L197G
R235Y
R235Y
E223F
E223F
K219A
K219A
E213Y
E213Y
Q234S
Q234S
K181T
K181T
K233L
K233L
D243G
D243G
L183F
L183F
L215I
L215I
A242T
A242T
D243I
D243I
K265I
K265I
K180L
K180L
R190D
R190D
L188Q
L188Q
D230T
D230T
H222E
H222E
K260H
K260H
I210G
I210G
K233F
K233F
K270G
K270G
E194E
E194E
Q184A
Q184A
M200fs
M200fs
E238fs
E238fs
L271V
L271V
E236L
E236L
Y267Q
Y267Q
R240H
R240H
E203D
E203D
E214N
E214N
G232M
G232M
A250H
A250H
E217D
E217D
R196E
R196E
L245M
L245M
T266Q
T266Q
L215G
L215G
E186W
E186W
D192I
D192I
K260S
K260S
K181F
K181F
L241M
L241M
Q251Y
Q251Y
F237fs
F237fs
A242H
A242H
K219K
K219K
A250V
A250V
Y267S
Y267S
T199T
T199T
L271L
L271L
L226E
L226E
N273W
N273W
E257F
E257F
R225G
R225G
M187L
M187L
E264I
E264I
Q255W
Q255W
D192N
D192N
K233R
K233R
E253L
E253L
R220F
R220F
F237V
F237V
N209R
N209R
K181C
K181C
D192S
D192S
V227Q
V227Q
E214Y
E214Y
E257C
E257C
A269D
A269D
E247D
E247D
Q251H
Q251H
E257H
E257H
D230I
D230I
D205L
D205L
E236G
E236G
E186N
E186N
E217Y
E217Y
R196S
R196S
E194S
E194S
Q258A
Q258A
D192W
D192W
K219H
K219H
S239R
S239R
M187H
M187H
Q246L
Q246L
V256T
V256T
R216T
R216T
S212D
S212D
L263E
L263E
K208L
K208L
E223T
E223T
K201H
K201H
Q198V
Q198V
Q182S
Q182S
Q234W
Q234W
E228T
E228T
M187P
M187P
E202K
E202K
K181E
K181E
Q184N
Q184N
N195W
N195W
Q207D
Q207D
L245H
L245H
D254T
D254T
Q234K
Q234K
M200E
M200E
E264Y
E264Y
E202fs
E202fs
R190C
R190C
Q258Y
Q258Y
S212K
S212K
M200C
M200C
A244R
A244R
T266G
T266G
E213fs
E213fs
A242E
A242E
T218Y
T218Y
E217S
E217S
Q198I
Q198I
Q258N
Q258N
L215R
L215R
E178V
E178V
E178P
E178P
A250W
A250W
R216Q
R216Q
Q251P
Q251P
L241P
L241P
E257E
E257E
F237S
F237S
S239N
S239N
R220W
R220W
E238E
E238E
K270L
K270L
K219F
K219F
F206W
F206W
M200A
M200A
F206M
F206M
E262M
E262M
E217K
E217K
I210L
I210L
K260G
K260G
V191G
V191G
L204D
L204D
E213W
E213W
D243Q
D243Q
K180W
K180W
E186S
E186S
Q251V
Q251V
Q207L
Q207L
Y211V
Y211V
A242V
A242V
E217T
E217T
R190W
R190W
L215S
L215S
Q255G
Q255G
M200G
M200G
V256Q
V256Q
R220T
R220T
N195D
N195D
A244F
A244F
K219P
K219P
M187A
M187A
R189R
R189R
D254I
D254I
E217H
E217H
Q234F
Q234F
S268Y
S268Y
F206A
F206A
R196M
R196M
E194C
E194C
A269F
A269F
K261P
K261P
Y267Y
Y267Y
E213T
E213T
E262T
E262T
K201L
K201L
R225W
R225W
L188P
L188P
N209A
N209A
D230H
D230H
F206S
F206S
S268R
S268R
S212C
S212C
R216G
R216G
Y267I
Y267I
E203G
E203G
K180Q
K180Q
L245W
L245W
V256F
V256F
N273S
N273S
Y259S
Y259S
E223S
E223S
A269A
A269A
E257S
E257S
Q207M
Q207M
Q255A
Q255A
N273E
N273E
A193Y
A193Y
E262C
E262C
R220K
R220K
D205H
D205H
K260A
K260A
E238H
E238H
A179I
A179I
E217Q
E217Q
R225Y
R225Y
L241H
L241H
D243S
D243S
M187R
M187R
R190F
R190F
F206Q
F206Q
L245Y
L245Y
Q184E
Q184E
A250N
A250N
D243T
D243T
E213E
E213E
N209F
N209F
K265N
K265N
Q182D
Q182D
I210R
I210R
L183M
L183M
E213R
E213R
L263M
L263M
A244W
A244W
T224V
T224V
L263D
L263D
N195V
N195V
E213A
E213A
S268E
S268E
N231W
N231W
E217W
E217W
Q246H
Q246H
I210S
I210S
N195A
N195A
D272H
D272H
E186F
E186F
N231E
N231E
R216M
R216M
L226V
L226V
D272W
D272W
Q255I
Q255I
H252L
H252L
Q255V
Q255V
D192P
D192P
Q207I
Q207I
K265P
K265P
L197I
L197I
A179N
A179N
E202I
E202I
E223C
E223C
A179Q
A179Q
I229A
I229A
R196Q
R196Q
R196I
R196I
E253Y
E253Y
E264A
E264A
K219E
K219E
K181Q
K181Q
F237Y
F237Y
D192K
D192K
R225A
R225A
Y259V
Y259V
Q184S
Q184S
D230K
D230K
L188N
L188N
E264S
E264S
D230Y
D230Y
T218P
T218P
E214S
E214S
F206C
F206C
R190Q
R190Q
Q258G
Q258G
L248M
L248M
Q251T
Q251T
E228L
E228L
V191Y
V191Y
Q182E
Q182E
D230fs
D230fs
F206V
F206V
L263L
L263L
D192Y
D192Y
A244D
A244D
M187C
M187C
Q246D
Q246D
K260T
K260T
L197E
L197E
Q198E
Q198E
D272R
D272R
I210P
I210P
L271R
L271R
D192H
D192H
R221H
R221H
L245S
L245S
A250G
A250G
K233W
K233W
R216W
R216W
L245P
L245P
L183E
L183E
T224D
T224D
K208H
K208H
E264F
E264F
K260R
K260R
Q207V
Q207V
A269H
A269H
D185G
D185G
V191F
V191F
R240S
R240S
N195T
N195T
K180H
K180H
M187F
M187F
E186P
E186P
R220V
R220V
Q182G
Q182G
R221D
R221D
K180G
K180G
K219N
K219N
Q207H
Q207H
R235D
R235D
E202Q
E202Q
N231C
N231C
T199G
T199G
E203N
E203N
Y259L
Y259L
R221Q
R221Q
N195G
N195G
T218V
T218V
Y259C
Y259C
M187V
M187V
L245F
L245F
D243K
D243K
L263Q
L263Q
A179F
A179F
A250D
A250D
S268P
S268P
T224H
T224H
L215E
L215E
E178G
E178G
D205Q
D205Q
L245V
L245V
D272G
D272G
K219D
K219D
G232P
G232P
D272K
D272K
K208S
K208S
E264H
E264H
E253D
E253D
K233Y
K233Y
K181G
K181G
K208T
K208T
A242D
A242D
L183I
L183I
R190N
R190N
K201R
K201R
L241C
L241C
M187D
M187D
N195H
N195H
H222M
H222M
D243C
D243C
Q234L
Q234L
E214Q
E214Q
H222V
H222V
Q182K
Q182K
K265S
K265S
V227K
V227K
R220D
R220D
L263S
L263S
E253P
E253P
A269G
A269G
K180I
K180I
T224Q
T224Q
L188A
L188A
L263V
L263V
L226fs
L226fs
I229S
I229S
L263A
L263A
A242A
A242A
Q255N
Q255N
L204M
L204M
K208fs
K208fs
K181N
K181N
D185K
D185K
S268C
S268C
S268S
S268S
A250K
A250K
K261M
K261M
L183L
L183L
N231M
N231M
Q184L
Q184L
L263G
L263G
E253C
E253C
L248F
L248F
E194L
E194L
E186T
E186T
Q246V
Q246V
E257T
E257T
Q246W
Q246W
E238C
E238C
L204V
L204V
Q255H
Q255H
L215C
L215C
V191I
V191I
E238S
E238S
Q207Q
Q207Q
Y211Q
Y211Q
V256C
V256C
E236V
E236V
Q184D
Q184D
N231Q
N231Q
E203K
E203K
S268F
S268F
E213F
E213F
S212R
S212R
K180C
K180C
Y211M
Y211M
S239Q
S239Q
E178L
E178L
E262R
E262R
Q258T
Q258T
R225F
R225F
S212P
S212P
A193M
A193M
V256D
V256D
L241I
L241I
D272I
D272I
Y211G
Y211G
R190H
R190H
L215F
L215F
A179W
A179W
E264D
E264D
A269S
A269S
A193G
A193G
T218I
T218I
M200H
M200H
L204S
L204S
K261H
K261H
L271M
L271M
D185I
D185I
R240A
R240A
E253W
E253W
D230V
D230V
H222D
H222D
K261L
K261L
K180E
K180E
T218K
T218K
V191fs
V191fs
Q198L
Q198L
A269L
A269L
E203Q
E203Q
N231H
N231H
A242F
A242F
Q255M
Q255M
S212F
S212F
D243R
D243R
A250S
A250S
D185C
D185C
R225P
R225P
E223A
E223A
V191A
V191A
V227G
V227G
L248D
L248D
Y211A
Y211A
R216K
R216K
E228G
E228G
A242K
A242K
E194I
E194I
T218E
T218E
D205K
D205K
Q182H
Q182H
V227D
V227D
K181M
K181M
R240E
R240E
F206H
F206H
D192G
D192G
L204A
L204A
H222T
H222T
N231L
N231L
A193C
A193C
Y259D
Y259D
L245L
L245L
R221N
R221N
L204L
L204L
L241Y
L241Y
Q207G
Q207G
K265R
K265R
H222L
H222L
S239D
S239D
T266V
T266V
L245C
L245C
Q198R
Q198R
D254M
D254M
Q251E
Q251E
L183G
L183G
K181H
K181H
Y267E
Y267E
E247E
E247E
L226M
L226M
K233E
K233E
R220M
R220M
R235I
R235I
K233P
K233P
R240L
R240L
S239E
S239E
D272N
D272N
I229I
I229I
D192C
D192C
S239M
S239M
K261E
K261E
L204H
L204H
Q255T
Q255T
Y211K
Y211K
E228S
E228S
L188S
L188S
E178W
E178W
S239A
S239A
L188R
L188R
A193Q
A193Q
S239V
S239V
Y259F
Y259F
Y211T
Y211T
E213D
E213D
K219L
K219L
R190V
R190V
A244S
A244S
Y267F
Y267F
D230D
D230D
H252D
H252D
E202S
E202S
L204P
L204P
N231D
N231D
R190M
R190M
Q234V
Q234V
E194W
E194W
D230C
D230C
R190K
R190K
K180K
K180K
E238T
E238T
L215V
L215V
Q234A
Q234A
L245E
L245E
E186D
E186D
E194Q
E194Q
I210Y
I210Y
R235L
R235L
L271Q
L271Q
K181V
K181V
L183S
L183S
Y259P
Y259P
E257R
E257R
L263R
L263R
E202E
E202E
H252C
H252C
K260I
K260I
R190I
R190I
D192F
D192F
E238F
E238F
E186M
E186M
K181W
K181W
R189K
R189K
F206K
F206K
H252F
H252F
A193A
A193A
K219T
K219T
E257G
E257G
K260Y
K260Y
E213K
E213K
R240D
R240D
L226N
L226N
K265L
K265L
E264G
E264G
D205A
D205A
L226C
L226C
L248K
L248K
H222S
H222S
R240V
R240V
N273M
N273M
N273Y
N273Y
L197P
L197P
L226I
L226I
R225N
R225N
S268G
S268G
I229C
I229C
L188G
L188G
E202N
E202N
T224G
T224G
R189D
R189D
Q184K
Q184K
K181S
K181S
E202D
E202D
M200Q
M200Q
N195F
N195F
Q207R
Q207R
H222P
H222P
G232K
G232K
D272A
D272A
L245G
L245G
A250Q
A250Q
L263T
L263T
E214T
E214T
D254H
D254H
R189Y
R189Y
E253E
E253E
Q184R
Q184R
K219Q
K219Q
D205P
D205P
L188C
L188C
L271C
L271C
T224L
T224L
E214L
E214L
I229R
I229R
T199Q
T199Q
L188D
L188D
Y211F
Y211F
I210A
I210A
K208W
K208W
Q246Q
Q246Q
T266P
T266P
G232Q
G232Q
Q251K
Q251K
K233H
K233H
D272V
D272V
Y267D
Y267D
N231G
N231G
D230Q
D230Q
V256V
V256V
D254L
D254L
K270N
K270N
E178N
E178N
Q234P
Q234P
R240Y
R240Y
E194N
E194N
I229L
I229L
F237C
F237C
Q251I
Q251I
Y267R
Y267R
E213L
E213L
A179D
A179D
T224E
T224E
M200D
M200D
F237G
F237G
L226K
L226K
G232H
G232H
L245R
L245R
K265V
K265V
L215Y
L215Y
R220G
R220G
K233N
K233N
Y267L
Y267L
V227S
V227S
R225I
R225I
K270I
K270I
Q255L
Q255L
L197K
L197K
Q258H
Q258H
H252G
H252G
E186G
E186G
R216N
R216N
L271K
L271K
L183W
L183W
R235A
R235A
T218C
T218C
K265W
K265W
R216L
R216L
L215K
L215K
S239H
S239H
K233Q
K233Q
T218L
T218L
F206fs
F206fs
F237T
F237T
D205G
D205G
R240P
R240P
R216E
R216E
E238L
E238L
T218M
T218M
D205F
D205F
L197M
L197M
F237R
F237R
N273D
N273D
D205W
D205W
M200I
M200I
E228H
E228H
A179S
A179S
D192R
D192R
D205Y
D205Y
Q207N
Q207N
L188K
L188K
E178R
E178R
N273R
N273R
E236I
E236I
E257K
E257K
E223M
E223M
A244I
A244I
N273I
N273I
A179H
A179H
E186I
E186I
Q258K
Q258K
E223E
E223E
A193L
A193L
A179L
A179L
K208C
K208C
Q182Q
Q182Q
E178K
E178K
E264T
E264T
Q255Q
Q255Q
E238G
E238G
A179E
A179E
Q234E
Q234E
R221S
R221S
L241T
L241T
L271P
L271P
G232R
G232R
N273P
N273P
A193H
A193H
D192M
D192M
F237F
F237F
E253T
E253T
E228P
E228P
D192D
D192D
Q182T
Q182T
R189S
R189S
L263F
L263F
H222A
H222A
H222Y
H222Y
Q234C
Q234C
E178Q
E178Q
V227E
V227E
G86fs
G86fs
E253R
E253R
A244L
A244L
N209G
N209G
Y267C
Y267C
Q255Y
Q255Y
E238N
E238N
Y211R
Y211R
M200F
M200F
T199D
T199D
D205E
D205E
S239Y
S239Y
K265C
K265C
V256I
V256I
A250P
A250P
A179G
A179G
E203V
E203V
L271H
L271H
E213N
E213N
A244Y
A244Y
S212Y
S212Y
S268D
S268D
E214R
E214R
S268Q
S268Q
Y211I
Y211I
E223Y
E223Y
T224N
T224N
D205V
D205V
S268V
S268V
G13fs
G13fs
A269C
A269C
V256M
V256M
R235R
R235R
V191E
V191E
N209H
N209H
H222R
H222R
K181I
K181I
E238A
E238A
K261F
K261F
A242L
A242L
Q234Y
Q234Y
D185F
D185F
M200T
M200T
E186R
E186R
Y267V
Y267V
L248N
L248N
V256P
V256P
E214M
E214M
E214D
E214D
Q234fs
Q234fs
L245D
L245D
L248Q
L248Q
L226R
L226R
K181fs
K181fs
K265T
K265T
Q198K
Q198K
E213V
E213V
A269E
A269E
R225K
R225K
R216Y
R216Y
L215D
L215D
K260N
K260N
L226W
L226W
L263I
L263I
S212I
S212I
M200Y
M200Y
R240K
R240K
E262Q
E262Q
N231Y
N231Y
K180F
K180F
S268K
S268K
Q251W
Q251W
Q184M
Q184M
R240C
R240C
E262K
E262K
R190T
R190T
D254F
D254F
H252W
H252W
N195R
N195R
D205N
D205N
L263H
L263H
R225R
R225R
T199A
T199A
E214G
E214G
L245K
L245K
V227M
V227M
E213P
E213P
D254E
D254E
T218A
T218A
D243F
D243F
D185A
D185A
V256W
V256W
K261S
K261S
L204Y
L204Y
E257Q
E257Q
D185D
D185D
A179R
A179R
Q251F
Q251F
K201A
K201A
N273C
N273C
T218R
T218R
H222I
H222I
T224M
T224M
E214H
E214H
N273L
N273L
K265M
K265M
T218Q
T218Q
L248L
L248L
Q234R
Q234R
G232E
G232E
E253M
E253M
E238W
E238W
L263N
L263N
D205D
D205D
D185S
D185S
L215T
L215T
S239C
S239C
K260P
K260P
Q198M
Q198M
D230L
D230L
E238P
E238P
A244E
A244E
L188F
L188F
Y267W
Y267W
Y211H
Y211H
Q207K
Q207K
E236Q
E236Q
E257I
E257I
E217C
E217C
D230W
D230W
Y267P
Y267P
N209T
N209T
N195E
N195E
L197A
L197A
Y211S
Y211S
Q182M
Q182M
Q184Q
Q184Q
Q198G
Q198G
V256K
V256K
L188I
L188I
T218S
T218S
V227R
V227R
Q255R
Q255R
R189M
R189M
Q182N
Q182N
T224R
T224R
R225V
R225V
D230A
D230A
T224A
T224A
Q184H
Q184H
Q246E
Q246E
L248I
L248I
V227N
V227N
L245T
L245T
G232I
G232I
H252R
H252R
K260E
K260E
R240R
R240R
E257V
E257V
E178C
E178C
V191S
V191S
L215N
L215N
A193T
A193T
I229P
I229P
H222C
H222C
E202W
E202W
E194Y
E194Y
H222Q
H222Q
Q184G
Q184G
E203H
E203H
D272S
D272S
N273Q
N273Q
F206P
F206P
D185L
D185L
Q182A
Q182A
D205T
D205T
K270V
K270V
R216I
R216I
L197V
L197V
I210fs
I210fs
Q251G
Q251G
K265D
K265D
E228Q
E228Q
E236E
E236E
E223Q
E223Q
Q251A
Q251A
Y267G
Y267G
V191L
V191L
K261C
K261C
S239G
S239G
Y259R
Y259R
G412fs
G412fs
E186H
E186H
H252N
H252N
E178D
E178D
N273F
N273F
R221T
R221T
L245N
L245N
K181A
K181A
A179K
A179K
V256N
V256N
N209K
N209K
R235M
R235M
Q258C
Q258C
N209W
N209W
E262A
E262A
H252Q
H252Q
Q198S
Q198S
L183P
L183P
L241Q
L241Q
D272F
D272F
D185Q
D185Q
E213G
E213G
V191P
V191P
R225E
R225E
E217M
E217M
R235W
R235W
E214A
E214A
I210E
I210E
A269Y
A269Y
D230R
D230R
E194H
E194H
E186K
E186K
K261V
K261V
N273N
N273N
R220S
R220S
I229K
I229K
D230S
D230S
K219R
K219R
Q246Y
Q246Y
L226F
L226F
Y211W
Y211W
R196W
R196W
T266M
T266M
E238R
E238R
I229T
I229T
H252Y
H252Y
E186C
E186C
V256G
V256G
L215A
L215A
E228C
E228C
E194F
E194F
Q182C
Q182C
A193I
A193I
R190Y
R190Y
K181K
K181K
R221G
R221G
E217I
E217I
L241S
L241S
A242Y
A242Y
R240T
R240T
A244P
A244P
E223D
E223D
V191R
V191R
L204N
L204N
D243M
D243M
G232C
G232C
D205S
D205S
V227T
V227T
R240N
R240N
L183T
L183T
E236T
E236T
Q246K
Q246K
S212N
S212N
K201M
K201M
F206R
F206R
L204R
L204R
H252V
H252V
A269K
A269K
K180N
K180N
Q255K
Q255K
R240W
R240W
R189W
R189W
R240Q
R240Q
R221K
R221K
D272Q
D272Q
Q246S
Q246S
S268H
S268H
A179P
A179P
K260D
K260D
T266fs
T266fs
G232V
G232V
Q234N
Q234N
K261D
K261D
Q184C
Q184C
L271F
L271F
E214P
E214P
Q258S
Q258S
H252H
H252H
R216S
R216S
D254P
D254P
L215P
L215P
L263fs
L263fs
A250L
A250L
K219Y
K219Y
E194D
E194D
E264R
E264R
A250R
A250R
H252T
H252T
R220E
R220E
E236F
E236F
E264Q
E264Q
Q198T
Q198T
E194V
E194V
I210I
I210I
Q246R
Q246R
T224fs
T224fs
L183Q
L183Q
K219G
K219G
D185M
D185M
A193R
A193R
E238D
E238D
A179C
A179C
K270Y
K270Y
I210V
I210V
A244H
A244H
Q258V
Q258V
K265E
K265E
H222H
H222H
T224I
T224I
E257A
E257A
D254Y
D254Y
K208I
K208I
E264W
E264W
E214F
E214F
L197R
L197R
D272L
D272L
D254W
D254W
L226G
L226G
A244M
A244M
R220I
R220I
E186Y
E186Y
D272P
D272P
Y267T
Y267T
D254G
D254G
L271G
L271G
Q258D
Q258D
K270R
K270R
V191N
V191N
Q234Q
Q234Q
K181R
K181R
A242M
A242M
L248W
L248W
R220Y
R220Y
S212E
S212E
G232F
G232F
A244C
A244C
D243W
D243W
L197F
L197F
K260M
K260M
K270D
K270D
A250T
A250T
S268N
S268N
L204Q
L204Q
E214K
E214K
I229Q
I229Q
K261R
K261R
L197S
L197S
T224W
T224W
E202Y
E202Y
K208G
K208G
A193F
A193F
A250C
A250C
A269I
A269I
K181Y
K181Y
N231T
N231T
K208P
K208P
Y259H
Y259H
H222F
H222F
T224Y
T224Y
I229N
I229N
K180Y
K180Y
D230M
D230M
V256fs
V256fs
H222K
H222K
Q184I
Q184I
S239I
S239I
R221P
R221P
K219C
K219C
K201S
K201S
E213Q
E213Q
E253G
E253G
E223R
E223R
L197N
L197N
F237Q
F237Q
L226P
L226P
K261G
K261G
E178A
E178A
F237M
F237M
Q184Y
Q184Y
E236Y
E236Y
R196R
R196R
L271E
L271E
K265K
K265K
K233V
K233V
L271W
L271W
K180V
K180V
Y211Y
Y211Y
A269V
A269V
E186A
E186A
R225M
R225M
E236D
E236D
N273V
N273V
K233K
K233K
R190L
R190L
D272C
D272C
E262G
E262G
E217N
E217N
T10fs
T10fs
M187I
M187I
E223P
E223P
N209E
N209E
K219M
K219M
T218W
T218W
Q255F
Q255F
L188Y
L188Y
R196N
R196N
Q198N
Q198N
G232D
G232D
E253Q
E253Q
E262N
E262N
R225L
R225L
D192V
D192V
K270K
K270K
L204G
L204G
D272M
D272M
K233C
K233C
E217A
E217A
D192T
D192T
Q182Y
Q182Y
V191W
V191W
D243L
D243L
V191C
V191C
L241R
L241R
V191Q
V191Q
A250A
A250A
E203W
E203W
Q182R
Q182R
Q182W
Q182W
R190P
R190P
T218T
T218T
E262D
E262D
E214E
E214E
M187T
M187T
E178Y
E178Y
V256S
V256S
L197D
L197D
Q258L
Q258L
D254N
D254N
R221C
R221C
N231A
N231A
E202V
E202V
E202G
E202G
T199I
T199I
S239F
S239F
A244N
A244N
K181P
K181P
L183A
L183A
R240M
R240M
K219W
K219W
K233D
K233D
K261Y
K261Y
L226S
L226S
N195N
N195N
K201P
K201P
V227L
V227L
Q234T
Q234T
Y211P
Y211P
K201V
K201V
E223H
E223H
E247Y
E247Y
L241N
L241N
L226H
L226H
D254K
D254K
L241F
L241F
K208V
K208V
R220R
R220R
D243H
D243H
E262V
E262V
S212A
S212A
Q198Y
Q198Y
D243V
D243V
L241D
L241D
V227W
V227W
T224K
T224K
K233G
K233G
N209Q
N209Q
Q182I
Q182I
E228V
E228V
L183V
L183V
R221L
R221L
Y259Y
Y259Y
D185V
D185V
E262P
E262P
R189V
R189V
L183D
L183D
L197L
L197L
I229V
I229V
Q234D
Q234D
N231S
N231S
I210Q
I210Q
T199V
T199V
E217R
E217R
L248R
L248R
D185N
D185N
K261N
K261N
V629fs
V629fs
E214C
E214C
A269N
A269N
K417fs
K417fs
I229E
I229E
Q258F
Q258F
K180T
K180T
L271I
L271I
T199N
T199N
L188T
L188T
N231F
N231F
D243E
D243E
R235V
R235V
K201W
K201W
K265A
K265A
E257W
E257W
N273K
N273K
H252I
H252I
V227C
V227C
S268M
S268M
R216P
R216P
R196F
R196F
R221Y
R221Y
F237P
F237P
A269Q
A269Q
R235E
R235E
K180S
K180S
L245I
L245I
F206Y
F206Y
E253F
E253F
T224T
T224T
L263K
L263K
R225S
R225S
N195L
N195L
L248S
L248S
Q207C
Q207C
A193K
A193K
D230N
D230N
Y211L
Y211L
R216C
R216C
E238V
E238V
L241A
L241A
N209Y
N209Y
K270A
K270A
E238K
E238K
Q207Y
Q207Y
E257M
E257M
K219V
K219V
E194fs
E194fs
E264K
E264K
D192L
D192L
H222W
H222W
E223K
E223K
A242S
A242S
L188M
L188M
F237D
F237D
Q255D
Q255D
L226D
L226D
E247M
E247M
F206G
F206G
N209I
N209I
I229G
I229G
L263Y
L263Y
E194T
E194T
E257L
E257L
H252E
H252E
Q198P
Q198P
R235F
R235F
R225H
R225H
N209C
N209C
A269W
A269W
D272Y
D272Y
E228E
E228E
E178I
E178I
E257P
E257P
R216D
R216D
R235K
R235K
L271N
L271N
R240F
R240F
S212S
S212S
Q258Q
Q258Q
V227I
V227I
Q255P
Q255P
K181L
K181L
K201Y
K201Y
E186Q
E186Q
E223G
E223G
V191M
V191M
R216H
R216H
Q234I
Q234I
D243D
D243D
D254D
D254D
A179V
A179V
R220L
R220L
I229M
I229M
E228M
E228M
L204E
L204E
Y259I
Y259I
E262S
E262S
V227Y
V227Y
L204F
L204F
R216V
R216V
Q198C
Q198C
N195C
N195C
E253K
E253K
E178F
E178F
Y211C
Y211C
K260L
K260L
E236W
E236W
S239S
S239S
D254R
D254R
M200V
M200V
F206I
F206I
L271Y
L271Y
Q251M
Q251M
Q255E
Q255E
K261T
K261T
M187W
M187W
M200N
M200N
R221E
R221E
M200L
M200L
E194M
E194M
E202F
E202F
L215Q
L215Q
E262W
E262W
Q246A
Q246A
N231V
N231V
Q182V
Q182V
N231K
N231K
Y211E
Y211E
A244V
A244V
A250Y
A250Y
D192E
D192E
E253H
E253H
E253N
E253N
H222G
H222G
K265F
K265F
H222N
H222N
D185Y
D185Y
E236S
E236S
I210C
I210C
S212H
S212H
A242R
A242R
R216F
R216F
I229F
I229F
E217F
E217F
R216A
R216A
S268A
S268A
K265G
K265G
R220A
R220A
L188V
L188V
E236A
E236A
M200K
M200K
A193P
A193P
V191H
V191H
A179Y
A179Y
K201Q
K201Q
K270H
K270H
K260F
K260F
R221V
R221V
E236H
E236H
R190A
R190A
F206L
F206L
R220C
R220C
E203I
E203I
A242I
A242I
D230G
D230G
N231N
N231N
Q207E
Q207E
L241L
L241L
Q234G
Q234G
D230P
D230P
E228W
E228W
E178M
E178M
Q255C
Q255C
E217E
E217E
D254A
D254A
R196V
R196V
A269T
A269T
Single Missense
Cluster 4
*Q
K260*
K*
Cluster 7
*N
E264*
E*
*V
E214*
Cluster 1
*F
Q184*
Q*
Q258*
*E
Cluster 2
E236*
*K
Cluster 6
V191*
V*
*T
*Y
N195*
N*
Cluster 10
M187*
M*
F237*
F*
*W
L248*
L*
Cluster 8
I210*
I*
*A
K180*
*S
E178*
N273*
Q198*
*D
Cluster 9
L271*
A244*
A*
*G
E194*
E217*
*H
A242*
*P
Cluster 5
*C
R196*
R*
Q251*
*R
*I
K261*
K208*
D185*
D*
L241*
Frameshift
R189*
L183*
Synonymous
A179*
Y211*
Y*
T224*
T*
L263*
E228*
V227*
A250*
*M
L215*
Y259*
Cluster 3
E213*
M200*
D254*
E257*
T199*
L226*
I229*
K233*
R190*
G232*
G*
K201*
E203*
Q207*
N209*
Y267*
*L
S268*
S*
Q246*
R235*
R220*
K270*
E238*
A269*
L197*
R225*
D205*
T218*
T266*
R240*
H252*
H*
R221*
A193*
E253*
K265*
S239*
R216*
E262*
E223*
S212*
V256*
D192*
Q234*
Anderson Punctate
ClinVar: P/LP
N231*
Q255*
E186*
K181*
F206*
D243*
Q182*
E202*
D230*
L188*
D272*
K219*
L204*
E247*
H222*
L245*
1.0
10.0
100.0
-12
-9
-6
-3
0
3
6
9
Log scale
Nuclei AreaShape FormFactor
Per variant images
Variant Synonymous
Variant Frameshift
