VISSEQ Data Explorer
About
Lamin A
PTEN iPSC
PTEN Neurons
Data download
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Selected variants
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Use the search bar and the add/remove buttons to select any variants or groups of variants you are interested in. They will show up highlighted in the UMAP and heatmap plots below. When you have made your selections, click the "Update plots" button to reload the page
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Synonymous
Frameshift
3nt Deletion
Nonsense
ClinVar: LP
ClinVar: P
ClinVar: LB
PHTS
ASD/DD
Somatic cancer
gnomAD controls
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Cluster 5
Cluster 6
Cluster 7
Cluster 8
Cluster 9
Cluster 10
Selected features
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Use the search bar and the add/remove buttons to select any cellular features you are interested in. By clicking on individual features they can be selected and removed using the remove button.
Search:
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Intensity MeanIntensity mEGFP-PTEN
Intensity MeanIntensity pAKT
Correlation Correlation DAPI mEGFP-PTEN
Variant UMAP
V119A|A120-
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161X
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170X
V133M
I122I|H123-
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144X
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163X
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
V166fs
A121D
M134X
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153-
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124X|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147X
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124X
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165X
I135W
A120D
R159-
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138X|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169X
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136X|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166X
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142X
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155X|G156-
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
V119A|A120-
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161X
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170X
V133M
I122I|H123-
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144X
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163X
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
V166fs
A121D
M134X
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153-
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124X|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147X
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124X
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165X
I135W
A120D
R159-
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138X|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169X
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136X|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166X
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142X
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155X|G156-
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
V119A|A120-
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161X
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170X
V133M
I122I|H123-
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144X
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163X
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
V166fs
A121D
M134X
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153-
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124X|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147X
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124X
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165X
I135W
A120D
R159-
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138X|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169X
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136X|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166X
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142X
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155X|G156-
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
V119A|A120-
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161X
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170X
V133M
I122I|H123-
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144X
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163X
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
V166fs
A121D
M134X
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153-
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124X|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147X
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124X
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165X
I135W
A120D
R159-
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138X|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169X
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136X|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166X
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142X
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155X|G156-
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
Color UMAP plot by:
None
Intensity MeanIntensity mEGFP-PTEN
Intensity MeanIntensity pAKT
Correlation Correlation DAPI mEGFP-PTEN
Randomly selected cell images
Variant: Synonymous
Variant: Frameshift
Volcano plot: Frameshift
-log10(pvalue)
Cytoplasm Correlation K DAPI ConA
Cytoplasm Granularity 13 DAPI
Cytoplasm Correlation Correlation DAPI MAP2
Correlation RWC DAPI ConA
Nuclei Texture InfoMeas1 DAPI 20 00 256
Cytoplasm AreaShape Solidity
Cytoplasm Texture DifferenceVariance pAKT 5 00 256
Granularity 5 DAPI
Nuclei AreaShape Compactness
Cytoplasm Texture DifferenceVariance pAKT 20 02 256
Correlation RWC pAKT mEGFP-PTEN
Nuclei Granularity 6 pAKT
Cytoplasm Texture Correlation ConA 10 00 256
Intensity MeanIntensityEdge mEGFP-PTEN
Nuclei Intensity MassDisplacement pAKT
Nuclei Intensity MinIntensityEdge MAP2
Cytoplasm RadialDistribution FracAtD pAKT 5of5
Nuclei Texture Variance pAKT 10 03 256
Cytoplasm Texture Variance pAKT 10 02 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 5 01 256
Texture DifferenceVariance mEGFP-PTEN 20 00 256
Texture SumVariance pAKT 10 01 256
Texture SumVariance pAKT 20 01 256
Texture InverseDifferenceMoment DAPI 5 00 256
Cytoplasm Intensity MADIntensity ConA
Texture Variance ConA 10 01 256
Texture SumAverage mEGFP-PTEN 10 00 256
Texture DifferenceVariance pAKT 5 01 256
Intensity MeanIntensityEdge ConA
Cytoplasm Texture Variance ConA 10 02 256
Nuclei Texture InfoMeas2 pAKT 20 03 256
Nuclei Texture SumVariance mEGFP-PTEN 20 02 256
Cytoplasm Texture Correlation pAKT 5 03 256
Correlation Overlap mEGFP-PTEN ConA
Cytoplasm Texture Entropy ConA 20 02 256
Cytoplasm Granularity 2 mEGFP-PTEN
Texture InfoMeas2 pAKT 10 02 256
Cytoplasm Texture InfoMeas1 DAPI 20 03 256
Nuclei Granularity 1 MAP2
Nuclei Texture SumEntropy ConA 10 00 256
Intensity MinIntensityEdge ConA
Texture DifferenceVariance pAKT 5 02 256
Texture InfoMeas2 ConA 20 03 256
Nuclei Texture Correlation ConA 10 01 256
Texture SumAverage ConA 20 03 256
Cytoplasm Texture Correlation DAPI 5 00 256
Nuclei Texture InverseDifferenceMoment pAKT 20 02 256
Cytoplasm Texture InverseDifferenceMoment ConA 20 03 256
Nuclei Texture SumAverage ConA 20 01 256
Cytoplasm Correlation K mEGFP-PTEN MAP2
Nuclei Texture Entropy DAPI 5 01 256
Nuclei Correlation K mEGFP-PTEN DAPI
Nuclei Texture SumAverage ConA 20 00 256
Texture InfoMeas1 mEGFP-PTEN 20 00 256
Texture DifferenceVariance pAKT 20 00 256
Texture InverseDifferenceMoment mEGFP-PTEN 20 01 256
Nuclei Texture SumVariance ConA 5 00 256
Cytoplasm Texture SumEntropy pAKT 10 00 256
Nuclei Texture Correlation DAPI 10 00 256
Texture InfoMeas1 pAKT 5 03 256
Nuclei RadialDistribution RadialCV pAKT 1of5
Nuclei Correlation Correlation DAPI ConA
Nuclei Texture SumVariance pAKT 10 00 256
Cytoplasm RadialDistribution RadialCV pAKT 4of5
Texture InverseDifferenceMoment ConA 5 03 256
Cytoplasm RadialDistribution RadialCV ConA 5of5
Cytoplasm Number Object Number
Intensity MinIntensityEdge mEGFP-PTEN
Texture InfoMeas2 mEGFP-PTEN 5 01 256
Nuclei Intensity IntegratedIntensity pAKT
Texture Entropy pAKT 5 00 256
Intensity MADIntensity mEGFP-PTEN
Cytoplasm Texture SumAverage pAKT 10 03 256
Texture Contrast ConA 10 02 256
Nuclei Intensity MedianIntensity MAP2
Cytoplasm Texture InverseDifferenceMoment ConA 10 01 256
Texture DifferenceEntropy ConA 10 01 256
Cytoplasm Texture SumVariance DAPI 5 03 256
Cytoplasm Correlation RWC MAP2 ConA
Cytoplasm Texture Contrast ConA 20 01 256
Texture SumEntropy DAPI 20 00 256
Texture Entropy DAPI 10 03 256
Cytoplasm Texture InverseDifferenceMoment DAPI 5 02 256
Cytoplasm Texture InverseDifferenceMoment pAKT 20 03 256
Nuclei Correlation Overlap DAPI MAP2
Texture DifferenceEntropy mEGFP-PTEN 5 02 256
Nuclei Intensity MeanIntensity ConA
RadialDistribution MeanFrac pAKT 2of5
Nuclei Texture SumVariance ConA 10 03 256
Nuclei Texture SumEntropy pAKT 5 00 256
Cytoplasm Texture SumAverage DAPI 10 00 256
Texture Contrast pAKT 10 02 256
Nuclei Texture SumEntropy ConA 20 00 256
Texture Contrast mEGFP-PTEN 5 02 256
Texture DifferenceEntropy mEGFP-PTEN 10 03 256
Cytoplasm Texture DifferenceVariance DAPI 10 00 256
Texture DifferenceVariance DAPI 20 00 256
Nuclei Texture SumEntropy DAPI 10 02 256
Nuclei RadialDistribution RadialCV pAKT 5of5
Nuclei Texture Entropy pAKT 5 03 256
Cytoplasm Texture InfoMeas1 pAKT 5 00 256
Nuclei Texture Contrast DAPI 5 00 256
Cytoplasm RadialDistribution RadialCV ConA 1of5
RadialDistribution FracAtD ConA 2of5
Nuclei Intensity MaxIntensity ConA
Texture DifferenceEntropy mEGFP-PTEN 10 02 256
Nuclei Intensity MassDisplacement ConA
Cytoplasm Granularity 3 DAPI
Intensity StdIntensityEdge pAKT
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 5 02 256
Nuclei Texture InfoMeas1 ConA 20 01 256
Texture DifferenceEntropy ConA 10 02 256
Cytoplasm Texture DifferenceEntropy ConA 20 02 256
Nuclei Texture DifferenceEntropy pAKT 20 02 256
Cytoplasm Texture Correlation pAKT 5 01 256
Cytoplasm Correlation Manders mEGFP-PTEN DAPI
Cytoplasm Texture DifferenceEntropy ConA 5 02 256
Texture SumEntropy pAKT 20 02 256
RadialDistribution FracAtD DAPI 1of5
Texture SumVariance DAPI 5 01 256
Nuclei Texture DifferenceVariance DAPI 10 03 256
Correlation Manders mEGFP-PTEN ConA
Texture SumAverage DAPI 10 00 256
Nuclei Texture SumAverage MAP2 20 00 256
Nuclei Texture Contrast mEGFP-PTEN 10 02 256
Intensity MassDisplacement DAPI
Texture DifferenceEntropy DAPI 5 02 256
Texture SumEntropy mEGFP-PTEN 5 01 256
Nuclei Texture DifferenceVariance MAP2 20 00 256
Texture DifferenceEntropy DAPI 20 03 256
Cytoplasm Texture InfoMeas1 DAPI 5 03 256
Cytoplasm Texture Contrast ConA 5 03 256
Cytoplasm Texture Variance DAPI 20 03 256
Texture SumAverage DAPI 20 02 256
Nuclei Texture DifferenceEntropy DAPI 5 00 256
Texture DifferenceEntropy ConA 20 03 256
Cytoplasm Granularity 12 mEGFP-PTEN
Cytoplasm Texture SumVariance pAKT 20 00 256
Texture SumAverage ConA 20 02 256
Texture Entropy ConA 10 02 256
Cytoplasm Intensity MADIntensity mEGFP-PTEN
Texture SumVariance ConA 5 02 256
Texture DifferenceVariance pAKT 20 01 256
Cytoplasm RadialDistribution FracAtD mEGFP-PTEN 4of5
Nuclei Texture InverseDifferenceMoment pAKT 20 03 256
Nuclei Intensity IntegratedIntensityEdge mEGFP-PTEN
Nuclei Texture SumVariance mEGFP-PTEN 10 01 256
Cytoplasm Texture SumVariance DAPI 20 01 256
Texture Variance ConA 10 03 256
Texture DifferenceEntropy ConA 10 00 256
Texture SumVariance mEGFP-PTEN 5 02 256
Texture SumAverage pAKT 10 03 256
Correlation K DAPI MAP2
Cytoplasm Intensity MinIntensityEdge pAKT
Texture InfoMeas1 ConA 10 01 256
Texture SumAverage mEGFP-PTEN 20 01 256
RadialDistribution MeanFrac DAPI 4of5
Cytoplasm Correlation Correlation MAP2 ConA
Texture Variance pAKT 5 00 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 10 02 256
Texture DifferenceVariance mEGFP-PTEN 10 03 256
Nuclei Intensity StdIntensityEdge MAP2
Nuclei Texture InfoMeas1 ConA 20 03 256
Nuclei Texture DifferenceEntropy DAPI 10 01 256
Intensity MeanIntensity DAPI
Nuclei Texture Contrast DAPI 10 03 256
Nuclei Correlation Costes mEGFP-PTEN MAP2
Texture Correlation mEGFP-PTEN 5 02 256
Nuclei Correlation K ConA MAP2
Cytoplasm Texture InverseDifferenceMoment pAKT 20 02 256
Cytoplasm Texture Correlation mEGFP-PTEN 20 01 256
Nuclei Texture Contrast pAKT 10 02 256
Nuclei Texture Correlation DAPI 10 03 256
Cytoplasm Texture InverseDifferenceMoment DAPI 20 00 256
Nuclei RadialDistribution MeanFrac pAKT 2of5
Cytoplasm Texture Contrast pAKT 10 01 256
Cytoplasm Correlation Manders pAKT DAPI
Texture SumAverage mEGFP-PTEN 20 00 256
Nuclei RadialDistribution FracAtD ConA 3of5
Texture Entropy DAPI 10 02 256
Cytoplasm Texture InverseDifferenceMoment pAKT 20 01 256
Cytoplasm AreaShape Perimeter
Nuclei Texture Contrast ConA 20 01 256
Texture SumEntropy mEGFP-PTEN 5 00 256
Nuclei Correlation RWC pAKT ConA
Texture InverseDifferenceMoment DAPI 20 03 256
Cytoplasm Intensity IntegratedIntensityEdge DAPI
Nuclei Texture DifferenceVariance DAPI 20 03 256
Cytoplasm Texture Entropy ConA 5 00 256
Texture SumVariance ConA 10 02 256
Nuclei Texture SumEntropy DAPI 10 00 256
Texture InfoMeas1 DAPI 10 01 256
Cytoplasm Texture DifferenceVariance DAPI 5 00 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 5 00 256
Granularity 13 ConA
Nuclei Texture SumVariance pAKT 5 03 256
Texture SumEntropy pAKT 10 01 256
Cytoplasm RadialDistribution RadialCV DAPI 5of5
Texture SumAverage DAPI 5 00 256
Cytoplasm Texture Contrast ConA 5 01 256
Cytoplasm Texture InverseDifferenceMoment pAKT 5 01 256
Nuclei Texture Correlation DAPI 5 02 256
Nuclei Texture InverseDifferenceMoment DAPI 20 00 256
Nuclei RadialDistribution RadialCV DAPI 2of5
Texture Correlation ConA 5 02 256
Texture SumVariance pAKT 10 03 256
Cytoplasm RadialDistribution FracAtD MAP2 3of5
Nuclei Texture Variance mEGFP-PTEN 10 02 256
Texture SumAverage pAKT 5 00 256
Cytoplasm Texture Correlation mEGFP-PTEN 5 02 256
Nuclei Texture DifferenceEntropy pAKT 10 03 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 5 00 256
Cytoplasm Texture SumAverage mEGFP-PTEN 20 01 256
Cytoplasm Granularity 8 DAPI
Texture Entropy DAPI 5 02 256
Texture Entropy mEGFP-PTEN 10 02 256
Cytoplasm Texture Correlation pAKT 10 02 256
Intensity MinIntensity mEGFP-PTEN
Texture InfoMeas1 pAKT 10 00 256
Nuclei Correlation RWC DAPI ConA
Nuclei Correlation Correlation mEGFP-PTEN ConA
Intensity MeanIntensity MAP2
Texture DifferenceEntropy DAPI 10 00 256
Nuclei Correlation RWC ConA DAPI
Nuclei Texture DifferenceEntropy DAPI 5 01 256
Texture SumVariance mEGFP-PTEN 20 00 256
Nuclei Texture Contrast pAKT 20 01 256
Texture InverseDifferenceMoment DAPI 5 03 256
Cytoplasm Texture Contrast DAPI 10 00 256
Texture SumEntropy pAKT 5 03 256
Texture InverseDifferenceMoment DAPI 5 01 256
Nuclei Texture SumEntropy ConA 20 01 256
Intensity MassDisplacement mEGFP-PTEN
Texture InverseDifferenceMoment mEGFP-PTEN 10 00 256
Texture DifferenceVariance pAKT 20 03 256
Nuclei Granularity 9 MAP2
Neighbors SecondClosestDistance Adjacent
Cytoplasm Granularity 9 DAPI
Texture SumVariance mEGFP-PTEN 20 01 256
Cytoplasm Correlation Overlap DAPI ConA
Nuclei Neighbors FirstClosestDistance 10
Cytoplasm Correlation Overlap mEGFP-PTEN MAP2
Cytoplasm Texture InfoMeas1 pAKT 5 03 256
Nuclei Texture Entropy ConA 5 02 256
Texture SumEntropy pAKT 20 03 256
Nuclei Texture Contrast DAPI 5 01 256
Cytoplasm Texture DifferenceEntropy ConA 5 01 256
Intensity MedianIntensity pAKT
Nuclei Texture Entropy mEGFP-PTEN 10 03 256
Nuclei Granularity 9 DAPI
Cytoplasm Texture SumAverage mEGFP-PTEN 5 01 256
Nuclei RadialDistribution RadialCV pAKT 4of5
Cytoplasm Texture InfoMeas1 ConA 20 00 256
Cytoplasm Granularity 7 DAPI
Nuclei Intensity MADIntensity ConA
Texture InfoMeas1 mEGFP-PTEN 5 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 10 01 256
Nuclei Texture SumEntropy DAPI 10 03 256
Texture InfoMeas2 DAPI 5 00 256
Intensity MedianIntensity mEGFP-PTEN
Texture Correlation pAKT 5 01 256
Cytoplasm Texture Entropy DAPI 20 00 256
Nuclei Texture DifferenceVariance ConA 10 03 256
Intensity IntegratedIntensity MAP2
Texture SumAverage ConA 20 01 256
Correlation Manders MAP2 ConA
Cytoplasm Texture SumEntropy ConA 20 00 256
Cytoplasm Intensity MinIntensity mEGFP-PTEN
Texture Contrast DAPI 20 02 256
Cytoplasm Texture Variance mEGFP-PTEN 10 01 256
Cytoplasm Granularity 1 DAPI
Nuclei Texture Correlation pAKT 10 01 256
Texture DifferenceVariance ConA 5 01 256
Cytoplasm Texture Correlation ConA 5 02 256
Nuclei Intensity MeanIntensity mEGFP-PTEN
Texture InfoMeas1 mEGFP-PTEN 5 00 256
Nuclei Texture SumVariance pAKT 20 02 256
Nuclei RadialDistribution RadialCV ConA 2of5
Nuclei Texture InfoMeas2 mEGFP-PTEN 5 01 256
Cytoplasm Texture SumAverage ConA 20 02 256
Granularity 4 mEGFP-PTEN
Texture SumAverage DAPI 20 00 256
Texture InverseDifferenceMoment pAKT 10 03 256
Granularity 2 mEGFP-PTEN
Intensity MADIntensity MAP2
Texture InfoMeas1 mEGFP-PTEN 20 01 256
RadialDistribution RadialCV MAP2 4of5
Nuclei Texture DifferenceEntropy mEGFP-PTEN 5 03 256
Nuclei Intensity MADIntensity DAPI
Nuclei Texture InfoMeas1 pAKT 10 01 256
Correlation Correlation DAPI MAP2
Texture SumVariance DAPI 10 00 256
Nuclei RadialDistribution FracAtD MAP2 3of5
Cytoplasm Texture Variance pAKT 10 03 256
Nuclei Texture SumAverage mEGFP-PTEN 10 02 256
Texture Entropy DAPI 20 03 256
Nuclei Texture InverseDifferenceMoment pAKT 20 01 256
Texture Contrast mEGFP-PTEN 20 00 256
Texture InfoMeas1 DAPI 20 01 256
Nuclei AreaShape Perimeter
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 20 00 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 10 00 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 10 00 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 10 00 256
Nuclei Correlation K MAP2 ConA
Intensity MaxIntensity mEGFP-PTEN
Nuclei Texture SumEntropy mEGFP-PTEN 20 03 256
RadialDistribution RadialCV ConA 2of5
Cytoplasm Texture InfoMeas2 ConA 20 01 256
Nuclei Texture SumAverage ConA 5 02 256
Cytoplasm Texture Contrast pAKT 20 03 256
Cytoplasm Texture Entropy ConA 10 02 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 20 01 256
Nuclei Texture DifferenceVariance pAKT 5 01 256
Cytoplasm Texture Contrast pAKT 20 02 256
Cytoplasm Correlation RWC MAP2 mEGFP-PTEN
Cytoplasm Texture InfoMeas2 ConA 5 00 256
RadialDistribution RadialCV ConA 4of5
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 10 01 256
Cytoplasm Texture Entropy mEGFP-PTEN 10 01 256
Cytoplasm Texture Contrast mEGFP-PTEN 20 00 256
Cytoplasm Correlation Overlap pAKT ConA
Cytoplasm Texture SumEntropy ConA 10 00 256
Cytoplasm Texture DifferenceVariance ConA 10 03 256
Texture DifferenceVariance DAPI 20 02 256
Cytoplasm Texture Correlation mEGFP-PTEN 20 03 256
Cytoplasm Granularity 2 ConA
Cytoplasm Texture InfoMeas1 pAKT 10 00 256
Cytoplasm Texture Entropy DAPI 20 03 256
Nuclei RadialDistribution MeanFrac ConA 5of5
Texture InfoMeas1 mEGFP-PTEN 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 10 01 256
Cytoplasm RadialDistribution FracAtD pAKT 3of5
Texture Variance DAPI 5 02 256
Correlation K MAP2 mEGFP-PTEN
Nuclei Texture SumEntropy pAKT 10 02 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 20 03 256
Nuclei Texture DifferenceEntropy pAKT 5 02 256
Nuclei Texture Variance pAKT 10 02 256
Texture SumAverage pAKT 20 03 256
Nuclei Texture SumAverage mEGFP-PTEN 5 00 256
Cytoplasm RadialDistribution RadialCV ConA 3of5
Cytoplasm Intensity MinIntensityEdge DAPI
Nuclei Texture InfoMeas1 mEGFP-PTEN 5 02 256
Cytoplasm Texture SumVariance DAPI 20 02 256
Nuclei RadialDistribution FracAtD pAKT 4of5
Correlation RWC DAPI MAP2
Cytoplasm Correlation Costes pAKT mEGFP-PTEN
Nuclei Texture InfoMeas2 ConA 5 01 256
Texture SumAverage ConA 20 00 256
Granularity 6 MAP2
Nuclei Texture Variance DAPI 20 01 256
RadialDistribution MeanFrac MAP2 3of5
Texture Contrast ConA 10 00 256
Nuclei Texture Entropy DAPI 10 01 256
Nuclei Texture Contrast ConA 10 03 256
Cytoplasm Texture SumEntropy pAKT 5 01 256
Correlation K MAP2 DAPI
Texture SumVariance pAKT 5 02 256
Nuclei Texture InfoMeas2 pAKT 20 01 256
Cytoplasm Texture Entropy mEGFP-PTEN 20 01 256
RadialDistribution MeanFrac MAP2 4of5
Cytoplasm Texture SumAverage mEGFP-PTEN 20 00 256
Texture InfoMeas1 ConA 5 01 256
Correlation Manders ConA DAPI
Granularity 10 mEGFP-PTEN
RadialDistribution MeanFrac ConA 3of5
Cytoplasm Texture DifferenceEntropy ConA 20 03 256
Texture Variance pAKT 10 01 256
Texture SumAverage DAPI 5 01 256
Cytoplasm RadialDistribution FracAtD ConA 5of5
Nuclei AreaShape Extent
Texture SumVariance DAPI 10 03 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 10 02 256
Nuclei RadialDistribution RadialCV MAP2 5of5
Cytoplasm Intensity StdIntensityEdge DAPI
Cytoplasm Texture SumVariance mEGFP-PTEN 5 00 256
Texture DifferenceEntropy pAKT 5 03 256
Nuclei Texture Entropy mEGFP-PTEN 10 00 256
Cytoplasm Texture InverseDifferenceMoment ConA 5 01 256
Texture SumAverage DAPI 10 03 256
Nuclei Texture Variance ConA 5 03 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 10 03 256
Texture Contrast pAKT 20 00 256
Cytoplasm RadialDistribution RadialCV pAKT 5of5
Cytoplasm Texture SumEntropy DAPI 20 01 256
Cytoplasm Intensity LowerQuartileIntensity mEGFP-PTEN
Cytoplasm Texture SumAverage mEGFP-PTEN 10 02 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 5 03 256
Intensity LowerQuartileIntensity MAP2
Nuclei Texture SumVariance mEGFP-PTEN 20 01 256
Cytoplasm Texture InfoMeas2 pAKT 10 00 256
Nuclei Texture InfoMeas2 DAPI 20 00 256
Texture InverseDifferenceMoment pAKT 5 02 256
Cytoplasm RadialDistribution FracAtD ConA 1of5
Nuclei Texture Entropy DAPI 5 00 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 20 02 256
Nuclei Texture Contrast mEGFP-PTEN 10 00 256
Cytoplasm Texture DifferenceEntropy pAKT 10 03 256
Nuclei Correlation RWC mEGFP-PTEN ConA
Texture Contrast mEGFP-PTEN 5 00 256
Cytoplasm Texture DifferenceEntropy DAPI 5 00 256
Intensity MinIntensity ConA
Cytoplasm Texture DifferenceVariance ConA 20 02 256
Cytoplasm Texture Correlation ConA 20 01 256
Cytoplasm Texture SumVariance mEGFP-PTEN 10 00 256
Cytoplasm Texture Contrast pAKT 5 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 10 03 256
Texture DifferenceEntropy DAPI 10 02 256
Nuclei RadialDistribution MeanFrac mEGFP-PTEN 2of5
RadialDistribution MeanFrac ConA 1of5
Texture InfoMeas2 mEGFP-PTEN 5 02 256
Granularity 2 pAKT
Nuclei Texture InfoMeas2 ConA 20 02 256
Cytoplasm Texture SumAverage pAKT 5 00 256
Correlation Correlation DAPI mEGFP-PTEN
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 5 02 256
AreaShape MedianRadius
Texture Correlation mEGFP-PTEN 10 00 256
Nuclei Texture Entropy ConA 5 03 256
Cytoplasm Texture InfoMeas2 ConA 5 01 256
Correlation Manders MAP2 DAPI
Cytoplasm Texture InfoMeas1 pAKT 10 01 256
Nuclei AreaShape MajorAxisLength
Correlation Costes DAPI MAP2
Nuclei Texture SumVariance ConA 20 02 256
Cytoplasm Texture SumEntropy DAPI 10 02 256
Cytoplasm Texture Entropy ConA 5 03 256
Cytoplasm Texture InverseDifferenceMoment pAKT 10 02 256
Nuclei Texture InfoMeas1 ConA 5 03 256
Texture InverseDifferenceMoment pAKT 20 02 256
Texture SumVariance ConA 20 03 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 10 03 256
Nuclei Intensity UpperQuartileIntensity MAP2
Cytoplasm Texture Variance pAKT 10 00 256
Correlation Correlation MAP2 ConA
Texture DifferenceEntropy mEGFP-PTEN 10 01 256
Nuclei Texture DifferenceVariance pAKT 5 03 256
RadialDistribution FracAtD mEGFP-PTEN 3of5
Texture Variance pAKT 10 00 256
Cytoplasm Granularity 6 MAP2
Texture InfoMeas1 pAKT 5 02 256
Cytoplasm Texture DifferenceVariance ConA 5 03 256
Nuclei Texture SumVariance pAKT 5 00 256
Nuclei Correlation K mEGFP-PTEN MAP2
Cytoplasm Texture SumEntropy ConA 5 00 256
Correlation Costes MAP2 DAPI
Cytoplasm Texture InverseDifferenceMoment ConA 5 00 256
Nuclei Texture InfoMeas1 ConA 5 02 256
Intensity IntegratedIntensityEdge pAKT
Cytoplasm Texture Entropy DAPI 10 02 256
Cytoplasm Granularity 5 MAP2
Nuclei RadialDistribution MeanFrac ConA 2of5
Nuclei Texture Contrast DAPI 20 00 256
Cytoplasm Texture DifferenceEntropy pAKT 20 02 256
Texture Variance mEGFP-PTEN 5 00 256
Texture SumVariance ConA 20 02 256
Nuclei Texture SumVariance mEGFP-PTEN 5 03 256
Cytoplasm Intensity MADIntensity DAPI
Cytoplasm Texture SumAverage ConA 20 01 256
Nuclei Texture DifferenceEntropy ConA 20 02 256
Cytoplasm RadialDistribution FracAtD mEGFP-PTEN 3of5
Cytoplasm Intensity IntegratedIntensityEdge ConA
Cytoplasm Correlation Correlation pAKT ConA
Texture DifferenceEntropy DAPI 20 01 256
Cytoplasm Texture Entropy DAPI 20 02 256
Texture Entropy DAPI 20 01 256
Texture DifferenceVariance mEGFP-PTEN 10 01 256
Nuclei Texture SumVariance DAPI 5 01 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 20 01 256
Intensity LowerQuartileIntensity DAPI
Cytoplasm Granularity 11 MAP2
Texture DifferenceEntropy pAKT 20 03 256
Texture InfoMeas1 ConA 5 02 256
Cytoplasm AreaShape MinorAxisLength
Nuclei Texture Entropy ConA 10 02 256
Nuclei Texture SumVariance pAKT 5 02 256
Nuclei Texture DifferenceEntropy DAPI 20 01 256
Nuclei Texture DifferenceVariance DAPI 20 00 256
Texture InverseDifferenceMoment ConA 20 02 256
RadialDistribution FracAtD mEGFP-PTEN 5of5
Nuclei Texture SumVariance mEGFP-PTEN 5 02 256
Nuclei Texture DifferenceEntropy pAKT 5 03 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 5 00 256
Granularity 11 mEGFP-PTEN
Nuclei Texture Variance ConA 20 03 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 5 00 256
Granularity 4 DAPI
Texture SumAverage pAKT 5 03 256
Correlation Costes mEGFP-PTEN MAP2
Cytoplasm Intensity StdIntensity ConA
Correlation Overlap mEGFP-PTEN MAP2
Correlation K pAKT DAPI
Nuclei Granularity 5 MAP2
Correlation Overlap DAPI ConA
Nuclei Texture SumEntropy DAPI 5 02 256
Cytoplasm Texture SumAverage ConA 20 00 256
Nuclei Texture Entropy mEGFP-PTEN 5 02 256
Cytoplasm Texture SumAverage pAKT 10 01 256
Texture SumEntropy mEGFP-PTEN 10 01 256
Texture Variance pAKT 20 03 256
Cytoplasm Texture SumVariance pAKT 20 02 256
Correlation Correlation MAP2 pAKT
Nuclei AreaShape FormFactor
Nuclei Granularity 5 DAPI
Texture Variance mEGFP-PTEN 20 01 256
Cytoplasm Intensity MeanIntensity mEGFP-PTEN
Texture Correlation mEGFP-PTEN 20 03 256
Cytoplasm RadialDistribution RadialCV mEGFP-PTEN 2of5
Cytoplasm Correlation K mEGFP-PTEN pAKT
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 5 00 256
Texture DifferenceEntropy ConA 5 02 256
Nuclei Correlation RWC DAPI MAP2
Granularity 7 MAP2
Correlation K MAP2 pAKT
Texture DifferenceVariance ConA 20 01 256
Nuclei Correlation RWC ConA pAKT
Nuclei RadialDistribution MeanFrac pAKT 5of5
Nuclei Granularity 2 MAP2
Cytoplasm Texture SumEntropy mEGFP-PTEN 20 00 256
Cytoplasm RadialDistribution RadialCV DAPI 4of5
Nuclei Correlation RWC mEGFP-PTEN MAP2
Cytoplasm Texture Contrast DAPI 20 03 256
Nuclei RadialDistribution MeanFrac pAKT 3of5
Texture Entropy ConA 5 01 256
RadialDistribution RadialCV mEGFP-PTEN 3of5
Texture SumVariance DAPI 20 00 256
Correlation K ConA DAPI
Cytoplasm Texture Contrast ConA 5 02 256
Nuclei Texture InfoMeas2 pAKT 10 02 256
Nuclei Texture Correlation ConA 10 02 256
Nuclei Texture DifferenceEntropy DAPI 10 02 256
Cytoplasm Texture SumEntropy DAPI 20 02 256
Texture SumVariance mEGFP-PTEN 5 01 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 20 03 256
Nuclei Texture SumEntropy pAKT 10 00 256
Texture Entropy mEGFP-PTEN 10 01 256
Cytoplasm Texture DifferenceEntropy DAPI 10 00 256
Texture Variance pAKT 20 01 256
Texture DifferenceEntropy ConA 20 00 256
Correlation Correlation mEGFP-PTEN ConA
Texture Contrast ConA 10 03 256
Texture SumEntropy DAPI 20 02 256
Cytoplasm Texture DifferenceEntropy ConA 20 00 256
Cytoplasm RadialDistribution MeanFrac pAKT 1of5
Nuclei Correlation Correlation MAP2 ConA
Nuclei Intensity MinIntensity MAP2
Intensity UpperQuartileIntensity DAPI
RadialDistribution FracAtD DAPI 5of5
Texture DifferenceVariance ConA 5 03 256
Nuclei Granularity 2 ConA
Nuclei Texture SumAverage pAKT 20 03 256
Nuclei Texture SumEntropy mEGFP-PTEN 5 02 256
Cytoplasm Texture Correlation DAPI 5 02 256
Cytoplasm Texture DifferenceEntropy pAKT 20 00 256
Texture DifferenceVariance ConA 10 00 256
Texture Correlation DAPI 20 00 256
Texture DifferenceVariance DAPI 10 00 256
Nuclei Texture InverseDifferenceMoment DAPI 10 01 256
Nuclei Correlation K mEGFP-PTEN pAKT
Cytoplasm Texture Variance DAPI 20 00 256
Texture SumEntropy mEGFP-PTEN 20 02 256
RadialDistribution MeanFrac pAKT 4of5
Nuclei Intensity MaxIntensity DAPI
Texture InfoMeas1 mEGFP-PTEN 5 01 256
Texture Entropy ConA 5 03 256
Granularity 12 ConA
Texture SumAverage pAKT 5 01 256
Nuclei Granularity 11 mEGFP-PTEN
Cytoplasm Texture Correlation ConA 10 02 256
Nuclei Texture InfoMeas1 ConA 10 00 256
Nuclei Texture Entropy pAKT 5 00 256
Cytoplasm Texture SumEntropy DAPI 10 03 256
Nuclei Correlation Costes DAPI MAP2
Nuclei Intensity MaxIntensityEdge pAKT
Nuclei Texture SumAverage mEGFP-PTEN 10 03 256
ObjectSkeleton NumberTrunks ExtSkeleton
Nuclei Granularity 7 mEGFP-PTEN
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 20 03 256
Nuclei Granularity 8 MAP2
Nuclei Intensity LowerQuartileIntensity mEGFP-PTEN
Neighbors AngleBetweenNeighbors Adjacent
Nuclei Texture DifferenceVariance MAP2 20 01 256
Cytoplasm Correlation K MAP2 pAKT
Texture Entropy DAPI 20 02 256
Nuclei Intensity IntegratedIntensityEdge ConA
Texture InfoMeas1 pAKT 20 01 256
Cytoplasm Texture DifferenceEntropy ConA 20 01 256
Intensity IntegratedIntensity DAPI
Texture Variance DAPI 10 02 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 20 02 256
Nuclei Granularity 2 mEGFP-PTEN
Cytoplasm Texture Correlation DAPI 10 02 256
Texture SumEntropy pAKT 5 02 256
Nuclei Texture DifferenceEntropy ConA 10 00 256
Cytoplasm Texture SumVariance mEGFP-PTEN 10 02 256
Nuclei Texture Variance pAKT 10 01 256
Cytoplasm RadialDistribution MeanFrac ConA 1of5
Nuclei RadialDistribution FracAtD DAPI 1of5
Nuclei Texture Entropy ConA 10 00 256
Cytoplasm Texture SumEntropy ConA 20 01 256
Cytoplasm Intensity MaxIntensityEdge ConA
Cytoplasm Texture InverseDifferenceMoment DAPI 20 01 256
Correlation RWC MAP2 mEGFP-PTEN
Nuclei Texture DifferenceEntropy mEGFP-PTEN 10 01 256
Cytoplasm Texture Correlation pAKT 20 03 256
Nuclei Intensity MeanIntensity pAKT
Cytoplasm Texture Variance ConA 20 03 256
Nuclei Texture Correlation DAPI 10 02 256
Granularity 11 DAPI
Texture SumVariance ConA 10 00 256
Nuclei Texture Variance mEGFP-PTEN 10 00 256
Nuclei Texture SumEntropy mEGFP-PTEN 10 00 256
Nuclei Texture Entropy ConA 10 01 256
Nuclei Texture Contrast ConA 10 00 256
Nuclei Texture InfoMeas1 DAPI 10 01 256
Correlation Overlap DAPI pAKT
Nuclei Texture DifferenceEntropy DAPI 10 00 256
Nuclei Texture InverseDifferenceMoment DAPI 10 00 256
Texture InfoMeas1 ConA 20 03 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 5 01 256
Nuclei Texture InfoMeas2 pAKT 5 00 256
Texture Correlation mEGFP-PTEN 5 03 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 20 01 256
Cytoplasm Texture SumAverage DAPI 20 01 256
Nuclei Texture DifferenceVariance ConA 5 00 256
Correlation Correlation mEGFP-PTEN pAKT
Cytoplasm Intensity StdIntensity DAPI
Texture SumAverage mEGFP-PTEN 5 02 256
RadialDistribution MeanFrac mEGFP-PTEN 2of5
Neighbors AngleBetweenNeighbors 30
Cytoplasm Texture InfoMeas2 ConA 20 03 256
Cytoplasm RadialDistribution MeanFrac pAKT 3of5
Cytoplasm Texture SumAverage pAKT 10 02 256
Texture SumVariance pAKT 20 02 256
Nuclei Texture Variance DAPI 10 02 256
Texture SumEntropy ConA 20 03 256
Texture InverseDifferenceMoment ConA 20 03 256
Texture InfoMeas2 mEGFP-PTEN 5 00 256
Nuclei Texture Variance pAKT 5 00 256
Nuclei Texture InfoMeas1 pAKT 5 01 256
Cytoplasm Texture InfoMeas1 DAPI 20 01 256
Cytoplasm Granularity 4 DAPI
Nuclei Texture SumVariance DAPI 10 02 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 10 02 256
Cytoplasm Texture Variance pAKT 20 02 256
Correlation Overlap DAPI mEGFP-PTEN
Texture DifferenceEntropy mEGFP-PTEN 20 02 256
Cytoplasm Correlation Manders pAKT ConA
RadialDistribution RadialCV DAPI 1of5
Cytoplasm Texture SumAverage mEGFP-PTEN 20 02 256
Nuclei Texture Entropy DAPI 5 03 256
Cytoplasm Texture InverseDifferenceMoment DAPI 10 02 256
Texture InfoMeas1 ConA 10 03 256
Texture Entropy pAKT 5 02 256
Intensity IntegratedIntensityEdge ConA
Nuclei Texture Entropy ConA 5 00 256
Cytoplasm Intensity MaxIntensity MAP2
Nuclei Granularity 13 ConA
AreaShape MeanRadius
Nuclei Texture InfoMeas2 mEGFP-PTEN 5 00 256
Intensity MADIntensity ConA
Cytoplasm Texture Entropy DAPI 20 01 256
Nuclei Texture DifferenceVariance DAPI 5 00 256
Texture Variance ConA 5 00 256
RadialDistribution MeanFrac MAP2 2of5
Nuclei RadialDistribution FracAtD mEGFP-PTEN 5of5
Texture SumEntropy pAKT 10 03 256
Cytoplasm Texture Variance ConA 10 03 256
Cytoplasm AreaShape MeanRadius
Nuclei Texture SumVariance DAPI 10 00 256
Correlation Manders mEGFP-PTEN DAPI
RadialDistribution MeanFrac DAPI 5of5
Cytoplasm Correlation RWC MAP2 pAKT
Nuclei Texture SumVariance ConA 10 01 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 20 02 256
Nuclei Texture SumEntropy mEGFP-PTEN 5 01 256
Nuclei Texture InverseDifferenceMoment ConA 10 01 256
Cytoplasm Intensity IntegratedIntensityEdge MAP2
Correlation RWC ConA pAKT
Texture Entropy pAKT 10 01 256
Texture DifferenceEntropy mEGFP-PTEN 5 03 256
Nuclei Texture DifferenceVariance DAPI 5 02 256
Cytoplasm Granularity 10 mEGFP-PTEN
Nuclei Texture Correlation DAPI 20 02 256
Correlation K pAKT ConA
Nuclei Texture SumAverage mEGFP-PTEN 5 01 256
Cytoplasm RadialDistribution RadialCV DAPI 1of5
Nuclei Texture Correlation mEGFP-PTEN 10 01 256
Cytoplasm RadialDistribution RadialCV DAPI 3of5
RadialDistribution FracAtD mEGFP-PTEN 4of5
Nuclei Texture Contrast pAKT 5 00 256
ObjectSkeleton TotalObjectSkeletonLength ExtSkeleton
Cytoplasm Texture Variance DAPI 10 01 256
Nuclei Correlation Overlap mEGFP-PTEN ConA
RadialDistribution MeanFrac DAPI 2of5
Nuclei Texture InfoMeas1 mEGFP-PTEN 20 00 256
Correlation K mEGFP-PTEN pAKT
Nuclei Texture SumAverage MAP2 20 02 256
Texture DifferenceVariance DAPI 5 00 256
Nuclei Intensity StdIntensity pAKT
Texture Entropy mEGFP-PTEN 5 00 256
Intensity MADIntensity pAKT
Nuclei Texture Contrast DAPI 20 02 256
Nuclei Texture Entropy mEGFP-PTEN 20 03 256
Texture Entropy ConA 20 01 256
Texture Entropy mEGFP-PTEN 20 00 256
Cytoplasm Correlation RWC DAPI ConA
Cytoplasm Granularity 9 ConA
Texture InfoMeas2 pAKT 5 00 256
Texture Variance pAKT 10 02 256
Nuclei RadialDistribution RadialCV mEGFP-PTEN 2of5
Cytoplasm Texture Contrast mEGFP-PTEN 5 03 256
Nuclei Texture SumAverage DAPI 10 02 256
Cytoplasm Texture DifferenceVariance pAKT 20 03 256
Nuclei Texture SumAverage ConA 5 01 256
Nuclei Texture DifferenceEntropy DAPI 20 02 256
Texture InverseDifferenceMoment pAKT 10 02 256
Texture SumEntropy mEGFP-PTEN 5 03 256
Texture SumEntropy DAPI 5 00 256
Cytoplasm Texture Entropy mEGFP-PTEN 5 03 256
Correlation RWC pAKT ConA
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 5 01 256
Nuclei Texture DifferenceEntropy DAPI 5 03 256
Nuclei AreaShape MeanRadius
Cytoplasm Texture SumVariance ConA 5 00 256
Cytoplasm AreaShape FormFactor
Cytoplasm RadialDistribution FracAtD DAPI 3of5
Cytoplasm Correlation Manders DAPI ConA
Texture InverseDifferenceMoment pAKT 20 01 256
Correlation Costes mEGFP-PTEN pAKT
Cytoplasm Texture InverseDifferenceMoment pAKT 5 03 256
Nuclei Texture SumAverage DAPI 20 03 256
Nuclei Texture SumEntropy ConA 10 03 256
Cytoplasm Texture InfoMeas2 ConA 10 02 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 10 03 256
Cytoplasm Intensity LowerQuartileIntensity DAPI
AreaShape Extent
Cytoplasm Correlation Correlation DAPI ConA
Cytoplasm RadialDistribution MeanFrac pAKT 4of5
AreaShape Area
Nuclei Texture DifferenceVariance ConA 5 03 256
Nuclei Texture SumEntropy mEGFP-PTEN 20 02 256
Nuclei Texture SumAverage mEGFP-PTEN 20 03 256
Cytoplasm Texture SumAverage mEGFP-PTEN 10 00 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 10 03 256
Correlation RWC ConA mEGFP-PTEN
Cytoplasm Texture DifferenceVariance DAPI 10 01 256
Texture Entropy pAKT 10 00 256
Texture Correlation DAPI 20 03 256
Nuclei Granularity 5 mEGFP-PTEN
Nuclei RadialDistribution MeanFrac mEGFP-PTEN 3of5
Cytoplasm Correlation K DAPI mEGFP-PTEN
Cytoplasm Texture Variance mEGFP-PTEN 20 03 256
Texture DifferenceVariance ConA 20 02 256
Texture InfoMeas2 mEGFP-PTEN 10 02 256
Texture InfoMeas1 ConA 20 00 256
Texture SumVariance DAPI 20 03 256
Texture Correlation pAKT 20 01 256
Cytoplasm Texture Entropy ConA 5 02 256
Nuclei Texture DifferenceEntropy pAKT 10 01 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 10 00 256
Granularity 12 DAPI
Cytoplasm Texture Variance DAPI 20 02 256
Cytoplasm Granularity 8 ConA
Nuclei Texture SumAverage pAKT 5 00 256
Nuclei RadialDistribution RadialCV ConA 5of5
Cytoplasm Texture SumVariance mEGFP-PTEN 10 01 256
Nuclei Intensity MinIntensityEdge mEGFP-PTEN
Cytoplasm Correlation RWC mEGFP-PTEN MAP2
Texture Correlation ConA 20 01 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 20 02 256
Nuclei Texture DifferenceVariance pAKT 10 01 256
Cytoplasm Intensity LowerQuartileIntensity pAKT
Nuclei Granularity 10 mEGFP-PTEN
Nuclei Correlation Overlap mEGFP-PTEN pAKT
Cytoplasm Granularity 13 ConA
Texture SumVariance pAKT 5 00 256
Nuclei Texture Entropy DAPI 20 02 256
Intensity MaxIntensityEdge MAP2
Granularity 8 DAPI
Nuclei Texture InfoMeas2 DAPI 20 01 256
Nuclei RadialDistribution RadialCV DAPI 4of5
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 10 01 256
Texture Contrast ConA 20 00 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 5 03 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 10 02 256
Nuclei Texture Correlation DAPI 5 01 256
Cytoplasm RadialDistribution MeanFrac MAP2 2of5
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 10 00 256
Cytoplasm Granularity 2 pAKT
Cytoplasm AreaShape EquivalentDiameter
Cytoplasm Intensity LowerQuartileIntensity ConA
Cytoplasm Texture SumVariance pAKT 10 02 256
Cytoplasm Texture SumAverage pAKT 5 02 256
Cytoplasm Texture DifferenceEntropy DAPI 20 02 256
Nuclei RadialDistribution FracAtD pAKT 2of5
RadialDistribution RadialCV mEGFP-PTEN 1of5
Nuclei Texture Correlation ConA 5 00 256
Nuclei Texture SumAverage mEGFP-PTEN 5 03 256
Nuclei Intensity LowerQuartileIntensity pAKT
Nuclei Texture Contrast pAKT 5 01 256
Cytoplasm RadialDistribution RadialCV MAP2 3of5
Texture InverseDifferenceMoment ConA 10 00 256
Cytoplasm Correlation K DAPI pAKT
Nuclei Texture SumAverage DAPI 5 03 256
Nuclei Texture InfoMeas2 ConA 10 03 256
Nuclei Texture InverseDifferenceMoment ConA 20 00 256
Nuclei Intensity UpperQuartileIntensity DAPI
Cytoplasm Texture SumVariance ConA 10 01 256
Texture SumEntropy mEGFP-PTEN 20 00 256
Intensity IntegratedIntensity pAKT
Nuclei Texture Contrast pAKT 10 00 256
Nuclei AreaShape MinorAxisLength
Nuclei Texture InfoMeas2 mEGFP-PTEN 10 01 256
Nuclei Texture DifferenceVariance DAPI 10 00 256
Nuclei Intensity StdIntensity ConA
Texture SumEntropy DAPI 10 00 256
Nuclei Texture SumAverage DAPI 20 02 256
Cytoplasm Correlation K ConA mEGFP-PTEN
Texture DifferenceVariance DAPI 10 01 256
Nuclei Granularity 4 MAP2
Texture InfoMeas1 ConA 5 00 256
Cytoplasm Texture DifferenceVariance DAPI 20 01 256
Intensity MaxIntensity pAKT
Texture Variance pAKT 5 03 256
RadialDistribution FracAtD MAP2 3of5
Nuclei AreaShape MinFeretDiameter
Cytoplasm Texture SumAverage DAPI 20 02 256
Texture Contrast ConA 20 03 256
Cytoplasm Texture SumVariance ConA 10 02 256
Correlation Correlation pAKT ConA
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 10 02 256
Nuclei Texture InverseDifferenceMoment MAP2 20 01 256
Intensity MeanIntensity pAKT
Nuclei RadialDistribution RadialCV mEGFP-PTEN 1of5
Nuclei Intensity MeanIntensityEdge mEGFP-PTEN
Texture Variance ConA 10 02 256
Nuclei Texture InverseDifferenceMoment ConA 5 01 256
Texture SumVariance ConA 10 03 256
Texture InfoMeas1 pAKT 20 03 256
Cytoplasm Texture Entropy mEGFP-PTEN 5 00 256
Cytoplasm RadialDistribution RadialCV MAP2 1of5
Intensity StdIntensity mEGFP-PTEN
Nuclei Texture Variance ConA 10 00 256
Texture DifferenceEntropy DAPI 10 01 256
Cytoplasm Texture SumEntropy ConA 5 01 256
Texture Correlation pAKT 5 03 256
Texture Contrast mEGFP-PTEN 20 03 256
Cytoplasm Texture SumAverage mEGFP-PTEN 5 02 256
Cytoplasm Texture Correlation DAPI 20 01 256
Texture InfoMeas2 mEGFP-PTEN 10 01 256
RadialDistribution FracAtD ConA 3of5
Nuclei Texture Correlation mEGFP-PTEN 10 00 256
Cytoplasm Texture Entropy pAKT 20 03 256
Cytoplasm Texture Variance mEGFP-PTEN 5 00 256
Texture InverseDifferenceMoment ConA 5 01 256
Texture Variance DAPI 10 01 256
RadialDistribution MeanFrac mEGFP-PTEN 5of5
RadialDistribution FracAtD pAKT 3of5
Texture SumAverage ConA 5 02 256
Nuclei Texture SumAverage ConA 20 03 256
Nuclei Texture InfoMeas2 ConA 20 01 256
Cytoplasm Texture Contrast pAKT 10 02 256
Cytoplasm RadialDistribution RadialCV pAKT 1of5
Nuclei Texture SumAverage ConA 10 02 256
Nuclei Intensity MeanIntensityEdge MAP2
Cytoplasm Texture SumEntropy pAKT 10 02 256
Nuclei Granularity 4 ConA
Nuclei Texture InverseDifferenceMoment MAP2 20 03 256
Nuclei Texture InfoMeas1 DAPI 10 00 256
Cytoplasm Texture SumVariance pAKT 5 00 256
Nuclei Texture Entropy DAPI 10 00 256
Cytoplasm Texture DifferenceEntropy DAPI 5 03 256
Nuclei Texture Correlation pAKT 5 02 256
Texture Correlation pAKT 5 02 256
Cytoplasm Texture Correlation pAKT 20 02 256
Intensity LowerQuartileIntensity mEGFP-PTEN
Nuclei Texture Correlation ConA 5 01 256
Cytoplasm Texture InfoMeas2 ConA 10 01 256
Texture Correlation DAPI 5 01 256
Granularity 11 ConA
Nuclei Texture InfoMeas2 pAKT 10 01 256
Nuclei RadialDistribution FracAtD DAPI 3of5
Texture Variance DAPI 10 00 256
Texture InfoMeas2 mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 10 02 256
Nuclei RadialDistribution MeanFrac ConA 4of5
Cytoplasm Texture SumAverage pAKT 20 01 256
Texture InfoMeas2 DAPI 5 01 256
Texture Variance mEGFP-PTEN 20 02 256
Cytoplasm AreaShape MaxFeretDiameter
Nuclei Intensity IntegratedIntensity DAPI
Cytoplasm Texture Variance mEGFP-PTEN 20 00 256
Texture Contrast pAKT 10 03 256
Texture Correlation ConA 10 00 256
Cytoplasm Texture Entropy mEGFP-PTEN 20 00 256
Cytoplasm Texture DifferenceVariance pAKT 10 01 256
Texture Contrast ConA 10 01 256
Nuclei Texture SumEntropy mEGFP-PTEN 10 01 256
Cytoplasm RadialDistribution FracAtD mEGFP-PTEN 1of5
Nuclei Granularity 6 ConA
Cytoplasm Texture Contrast ConA 10 00 256
Cytoplasm Texture Contrast mEGFP-PTEN 10 02 256
Nuclei AreaShape MedianRadius
Texture SumEntropy DAPI 10 01 256
Texture InfoMeas1 ConA 10 02 256
RadialDistribution RadialCV pAKT 2of5
Nuclei Granularity 10 ConA
Cytoplasm Texture SumAverage ConA 5 01 256
Nuclei Intensity MedianIntensity DAPI
Cytoplasm Texture Correlation mEGFP-PTEN 10 00 256
Correlation K mEGFP-PTEN MAP2
Texture DifferenceEntropy DAPI 5 03 256
Nuclei Neighbors SecondClosestDistance 10
Nuclei Texture InfoMeas2 ConA 10 02 256
Texture Correlation ConA 5 03 256
Cytoplasm Intensity MassDisplacement DAPI
Intensity UpperQuartileIntensity pAKT
RadialDistribution MeanFrac DAPI 1of5
Texture DifferenceVariance mEGFP-PTEN 10 00 256
Nuclei RadialDistribution FracAtD pAKT 5of5
Correlation RWC pAKT DAPI
Nuclei Texture Correlation pAKT 10 03 256
Nuclei Texture InfoMeas1 ConA 5 01 256
Nuclei Texture DifferenceEntropy ConA 10 01 256
Cytoplasm Texture Contrast DAPI 20 02 256
Cytoplasm Texture DifferenceEntropy DAPI 10 01 256
Correlation K pAKT mEGFP-PTEN
Nuclei Texture Correlation DAPI 5 03 256
Nuclei Texture DifferenceEntropy ConA 5 03 256
Nuclei Correlation Overlap MAP2 ConA
Cytoplasm Texture SumVariance pAKT 20 01 256
Cytoplasm Correlation K MAP2 mEGFP-PTEN
Cytoplasm Texture InfoMeas2 DAPI 20 03 256
Texture Contrast DAPI 5 03 256
Texture DifferenceEntropy DAPI 20 00 256
Texture Contrast pAKT 5 02 256
Nuclei Texture InfoMeas1 pAKT 5 03 256
Texture Contrast pAKT 10 00 256
Cytoplasm Texture Correlation ConA 20 03 256
Texture InfoMeas1 DAPI 10 00 256
Texture InfoMeas2 pAKT 20 01 256
Nuclei Texture Entropy ConA 10 03 256
Texture InfoMeas1 mEGFP-PTEN 10 01 256
Cytoplasm Intensity UpperQuartileIntensity mEGFP-PTEN
RadialDistribution FracAtD ConA 4of5
Texture Correlation ConA 10 02 256
Nuclei Texture SumVariance ConA 20 01 256
Texture InverseDifferenceMoment mEGFP-PTEN 20 03 256
Cytoplasm Texture InverseDifferenceMoment DAPI 20 02 256
Cytoplasm Correlation K mEGFP-PTEN DAPI
Nuclei Texture SumVariance DAPI 20 00 256
Cytoplasm Correlation Overlap mEGFP-PTEN ConA
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 10 00 256
Cytoplasm Texture Contrast DAPI 5 01 256
Texture SumAverage ConA 5 03 256
Cytoplasm Texture SumAverage ConA 20 03 256
Cytoplasm RadialDistribution RadialCV mEGFP-PTEN 4of5
Nuclei Texture DifferenceEntropy ConA 20 00 256
Cytoplasm Texture Entropy pAKT 5 01 256
Cytoplasm Texture Correlation DAPI 20 00 256
Cytoplasm RadialDistribution MeanFrac mEGFP-PTEN 1of5
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 5 00 256
Cytoplasm Granularity 5 DAPI
Cytoplasm Correlation K ConA pAKT
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 10 01 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 20 03 256
Cytoplasm Texture Entropy ConA 20 01 256
Texture SumEntropy mEGFP-PTEN 10 03 256
Nuclei Texture SumEntropy DAPI 5 01 256
Nuclei Texture InfoMeas1 ConA 10 02 256
Texture InfoMeas1 pAKT 20 00 256
Cytoplasm Granularity 8 mEGFP-PTEN
Cytoplasm Texture SumEntropy DAPI 5 00 256
Cytoplasm Texture InfoMeas2 ConA 5 03 256
Nuclei Intensity MADIntensity MAP2
Granularity 10 ConA
Nuclei Texture Entropy pAKT 10 02 256
Cytoplasm Granularity 1 pAKT
Cytoplasm Texture SumVariance ConA 20 00 256
Nuclei RadialDistribution RadialCV ConA 4of5
Nuclei Texture Entropy DAPI 20 01 256
Cytoplasm Texture SumAverage ConA 5 02 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 10 00 256
Nuclei Texture Correlation pAKT 5 00 256
Cytoplasm Granularity 10 MAP2
Texture InfoMeas2 DAPI 20 01 256
Texture SumVariance pAKT 5 03 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 5 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 5 00 256
Texture SumEntropy ConA 10 01 256
Cytoplasm Texture SumAverage pAKT 20 02 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 20 01 256
Nuclei Intensity MeanIntensity MAP2
Cytoplasm Texture InverseDifferenceMoment ConA 10 02 256
Cytoplasm Texture SumAverage pAKT 5 03 256
Texture SumEntropy pAKT 20 01 256
Cytoplasm Intensity MaxIntensityEdge DAPI
Texture Contrast pAKT 5 00 256
Nuclei Correlation K DAPI ConA
Cytoplasm Texture Correlation DAPI 10 01 256
Granularity 7 DAPI
Cytoplasm Texture Contrast mEGFP-PTEN 10 00 256
Cytoplasm Texture Contrast mEGFP-PTEN 5 01 256
RadialDistribution MeanFrac pAKT 5of5
Cytoplasm Texture SumAverage ConA 10 01 256
Cytoplasm Texture InverseDifferenceMoment ConA 5 02 256
Cytoplasm RadialDistribution FracAtD ConA 4of5
Nuclei Texture SumAverage mEGFP-PTEN 5 02 256
Nuclei Texture Variance DAPI 5 01 256
Cytoplasm Texture InfoMeas1 ConA 5 00 256
Nuclei Texture Entropy DAPI 5 02 256
Cytoplasm Granularity 4 ConA
Cytoplasm Intensity MaxIntensityEdge mEGFP-PTEN
Texture InfoMeas2 ConA 20 02 256
Texture InfoMeas2 ConA 5 01 256
Texture SumEntropy mEGFP-PTEN 10 00 256
Texture SumVariance mEGFP-PTEN 10 01 256
Intensity StdIntensity MAP2
Texture InfoMeas1 pAKT 5 00 256
Nuclei Texture Contrast DAPI 10 00 256
Nuclei Granularity 7 MAP2
Texture Contrast pAKT 5 03 256
Cytoplasm Texture DifferenceVariance ConA 5 02 256
Cytoplasm Texture SumAverage pAKT 5 01 256
Texture InverseDifferenceMoment mEGFP-PTEN 5 02 256
Nuclei Texture Entropy mEGFP-PTEN 5 00 256
Texture Entropy DAPI 20 00 256
Texture SumVariance ConA 5 00 256
Texture InfoMeas2 mEGFP-PTEN 10 03 256
Texture Entropy ConA 5 00 256
Nuclei Texture SumVariance pAKT 10 01 256
Intensity MedianIntensity MAP2
Nuclei AreaShape EquivalentDiameter
Granularity 10 MAP2
Intensity MeanIntensityEdge MAP2
Cytoplasm Texture Entropy DAPI 10 03 256
Cytoplasm Intensity UpperQuartileIntensity DAPI
Nuclei Texture InfoMeas2 mEGFP-PTEN 10 03 256
Nuclei RadialDistribution RadialCV pAKT 2of5
Nuclei Granularity 5 ConA
Nuclei Texture InfoMeas1 ConA 10 01 256
Cytoplasm Texture DifferenceEntropy pAKT 10 01 256
Cytoplasm Intensity MeanIntensityEdge DAPI
Texture InverseDifferenceMoment ConA 10 03 256
Cytoplasm RadialDistribution MeanFrac mEGFP-PTEN 3of5
Nuclei Texture Correlation mEGFP-PTEN 20 02 256
Cytoplasm Granularity 11 mEGFP-PTEN
Cytoplasm Texture Entropy pAKT 10 01 256
Texture InverseDifferenceMoment pAKT 10 01 256
Texture Entropy mEGFP-PTEN 10 03 256
Cytoplasm Texture InfoMeas1 ConA 10 03 256
Texture InfoMeas2 pAKT 20 00 256
Texture DifferenceEntropy ConA 5 00 256
Cytoplasm Texture Variance mEGFP-PTEN 20 02 256
Texture SumAverage pAKT 20 01 256
Cytoplasm Texture Entropy pAKT 20 02 256
Cytoplasm RadialDistribution FracAtD ConA 3of5
Cytoplasm Texture Entropy DAPI 5 01 256
Nuclei Texture SumVariance pAKT 20 00 256
Cytoplasm AreaShape Area
RadialDistribution FracAtD ConA 5of5
Nuclei Texture Correlation DAPI 10 01 256
Cytoplasm Texture Variance ConA 5 01 256
Cytoplasm Texture InfoMeas1 ConA 10 02 256
Cytoplasm Intensity MeanIntensityEdge ConA
Nuclei Correlation Correlation MAP2 pAKT
RadialDistribution RadialCV MAP2 3of5
Nuclei Texture DifferenceVariance pAKT 20 02 256
Nuclei Texture Correlation mEGFP-PTEN 10 02 256
Cytoplasm Texture InfoMeas1 ConA 5 02 256
Nuclei Texture DifferenceVariance pAKT 20 01 256
Nuclei Texture DifferenceVariance ConA 10 02 256
Nuclei Intensity IntegratedIntensity MAP2
Cytoplasm Texture InfoMeas2 pAKT 20 00 256
Nuclei Texture Variance ConA 20 02 256
Nuclei Texture Correlation pAKT 10 02 256
Cytoplasm Texture Contrast DAPI 20 00 256
Cytoplasm Texture SumVariance ConA 10 00 256
RadialDistribution FracAtD MAP2 1of5
Texture SumEntropy pAKT 5 00 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 10 00 256
Nuclei Texture Variance pAKT 20 03 256
Cytoplasm Texture DifferenceEntropy ConA 10 03 256
Texture Contrast mEGFP-PTEN 5 03 256
Texture SumAverage mEGFP-PTEN 5 01 256
Nuclei Texture InfoMeas1 DAPI 10 03 256
Cytoplasm Correlation K MAP2 DAPI
Cytoplasm Granularity 2 MAP2
Cytoplasm Texture SumVariance ConA 5 01 256
Cytoplasm Texture InfoMeas2 DAPI 10 02 256
Cytoplasm Texture Entropy pAKT 10 00 256
Cytoplasm Texture SumAverage DAPI 20 03 256
Texture DifferenceVariance mEGFP-PTEN 5 03 256
Correlation K mEGFP-PTEN ConA
Cytoplasm Texture Correlation mEGFP-PTEN 5 01 256
Cytoplasm Texture DifferenceVariance ConA 5 00 256
Texture InfoMeas2 mEGFP-PTEN 20 03 256
Texture DifferenceVariance mEGFP-PTEN 20 03 256
Cytoplasm Texture Variance ConA 5 00 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 20 03 256
Number Object Number
Texture Entropy mEGFP-PTEN 10 00 256
Nuclei Texture SumAverage pAKT 10 03 256
Texture DifferenceVariance pAKT 10 02 256
Cytoplasm Intensity StdIntensityEdge ConA
Intensity MADIntensity DAPI
Cytoplasm Texture DifferenceEntropy ConA 10 01 256
Nuclei Texture InverseDifferenceMoment DAPI 20 01 256
Cytoplasm Granularity 2 DAPI
Cytoplasm Texture SumVariance DAPI 5 00 256
Cytoplasm RadialDistribution RadialCV pAKT 2of5
Intensity IntegratedIntensityEdge MAP2
Granularity 1 mEGFP-PTEN
Texture Entropy ConA 10 00 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 20 00 256
Nuclei Texture SumAverage mEGFP-PTEN 20 01 256
Nuclei Intensity StdIntensityEdge ConA
Nuclei Texture SumVariance ConA 5 01 256
Nuclei Texture Correlation MAP2 20 00 256
Texture DifferenceEntropy pAKT 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 10 03 256
Nuclei Texture Contrast ConA 10 01 256
Texture Correlation ConA 5 00 256
Cytoplasm Intensity StdIntensityEdge MAP2
Nuclei Texture DifferenceEntropy ConA 10 03 256
Texture DifferenceEntropy ConA 5 03 256
Texture InfoMeas1 ConA 10 00 256
Cytoplasm Intensity MedianIntensity pAKT
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 20 02 256
Nuclei Texture Variance pAKT 10 00 256
Nuclei Texture SumEntropy mEGFP-PTEN 20 00 256
Cytoplasm RadialDistribution RadialCV MAP2 4of5
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 10 02 256
Nuclei Texture DifferenceVariance ConA 10 00 256
Texture SumVariance mEGFP-PTEN 5 00 256
Nuclei Texture InfoMeas2 DAPI 5 03 256
Intensity MeanIntensityEdge pAKT
Correlation RWC MAP2 ConA
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 10 00 256
Intensity MaxIntensity ConA
Texture DifferenceVariance mEGFP-PTEN 5 01 256
Texture SumVariance DAPI 5 03 256
Cytoplasm Texture Correlation DAPI 10 03 256
Cytoplasm RadialDistribution FracAtD MAP2 1of5
Texture Variance ConA 5 02 256
Cytoplasm Intensity MinIntensity MAP2
Granularity 10 DAPI
Texture InfoMeas2 DAPI 20 03 256
Cytoplasm Granularity 5 pAKT
Nuclei Texture Variance DAPI 20 03 256
Cytoplasm Texture Variance DAPI 10 00 256
RadialDistribution RadialCV mEGFP-PTEN 5of5
Texture InfoMeas1 ConA 5 03 256
Nuclei Texture SumVariance ConA 5 03 256
Nuclei Texture Entropy DAPI 20 03 256
RadialDistribution MeanFrac mEGFP-PTEN 3of5
Cytoplasm Texture SumAverage ConA 10 03 256
Texture Contrast pAKT 5 01 256
Cytoplasm Texture SumVariance ConA 20 02 256
Cytoplasm Intensity UpperQuartileIntensity pAKT
Nuclei Correlation K DAPI pAKT
Cytoplasm Texture SumVariance mEGFP-PTEN 20 00 256
Cytoplasm Granularity 3 mEGFP-PTEN
Granularity 3 ConA
Intensity MedianIntensity ConA
Intensity MaxIntensity DAPI
Intensity MaxIntensityEdge pAKT
Nuclei Texture Variance DAPI 5 02 256
Cytoplasm Texture Correlation ConA 5 00 256
Nuclei Intensity MedianIntensity mEGFP-PTEN
Texture InfoMeas1 ConA 20 02 256
Cytoplasm Granularity 8 pAKT
Nuclei Texture SumAverage mEGFP-PTEN 10 01 256
Nuclei RadialDistribution MeanFrac MAP2 5of5
Nuclei RadialDistribution FracAtD MAP2 5of5
Nuclei Texture Entropy ConA 20 03 256
Cytoplasm Intensity MaxIntensity DAPI
Nuclei RadialDistribution MeanFrac MAP2 2of5
Nuclei Texture Entropy mEGFP-PTEN 5 03 256
Texture DifferenceEntropy mEGFP-PTEN 10 00 256
Nuclei Texture Variance DAPI 20 02 256
Cytoplasm Texture SumEntropy pAKT 5 02 256
Cytoplasm Texture Contrast mEGFP-PTEN 20 03 256
Cytoplasm Texture DifferenceEntropy DAPI 5 01 256
Nuclei Texture SumVariance mEGFP-PTEN 20 00 256
RadialDistribution FracAtD DAPI 4of5
Texture Correlation mEGFP-PTEN 20 01 256
Texture SumVariance pAKT 20 03 256
Texture SumEntropy mEGFP-PTEN 20 01 256
Cytoplasm Correlation K DAPI MAP2
Cytoplasm Texture SumEntropy mEGFP-PTEN 10 01 256
Texture Contrast ConA 20 01 256
Nuclei Texture Variance mEGFP-PTEN 5 03 256
Cytoplasm RadialDistribution MeanFrac MAP2 3of5
Nuclei Texture Entropy pAKT 5 01 256
Texture Correlation mEGFP-PTEN 5 00 256
Cytoplasm Granularity 9 mEGFP-PTEN
Texture InverseDifferenceMoment ConA 5 02 256
Texture Correlation DAPI 20 01 256
Texture Correlation mEGFP-PTEN 20 02 256
Nuclei Texture DifferenceVariance pAKT 20 00 256
Cytoplasm Texture DifferenceEntropy pAKT 5 01 256
Nuclei Texture InfoMeas1 DAPI 5 01 256
Cytoplasm Texture DifferenceEntropy pAKT 5 02 256
Texture DifferenceEntropy ConA 5 01 256
Texture Contrast ConA 5 01 256
Nuclei Texture Variance mEGFP-PTEN 20 01 256
Cytoplasm Texture DifferenceVariance pAKT 10 00 256
Nuclei Texture DifferenceEntropy DAPI 20 00 256
Cytoplasm Intensity MinIntensityEdge mEGFP-PTEN
Nuclei Texture Variance ConA 10 03 256
Texture DifferenceEntropy mEGFP-PTEN 20 00 256
Cytoplasm Texture Correlation mEGFP-PTEN 10 01 256
Texture Entropy DAPI 10 01 256
Texture InverseDifferenceMoment DAPI 5 02 256
Nuclei Intensity MaxIntensityEdge DAPI
RadialDistribution MeanFrac DAPI 3of5
Nuclei Texture SumVariance pAKT 20 01 256
Cytoplasm Texture InfoMeas1 pAKT 20 03 256
Texture SumEntropy DAPI 5 03 256
Texture Entropy ConA 20 03 256
Texture Variance pAKT 10 03 256
Texture InfoMeas1 DAPI 5 01 256
Nuclei RadialDistribution FracAtD ConA 2of5
Texture SumEntropy mEGFP-PTEN 20 03 256
Nuclei Texture SumVariance ConA 20 03 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 20 01 256
Cytoplasm Granularity 4 pAKT
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 5 01 256
Texture DifferenceVariance DAPI 20 03 256
Nuclei Correlation Overlap pAKT ConA
Nuclei Texture SumEntropy ConA 20 02 256
Cytoplasm Correlation RWC mEGFP-PTEN DAPI
Nuclei AreaShape ConvexArea
Cytoplasm Texture SumAverage mEGFP-PTEN 5 00 256
Nuclei Granularity 3 MAP2
Nuclei Intensity MeanIntensityEdge ConA
RadialDistribution RadialCV mEGFP-PTEN 4of5
Granularity 8 pAKT
Texture InverseDifferenceMoment DAPI 10 03 256
Nuclei Texture Contrast ConA 5 03 256
Nuclei Texture Contrast pAKT 10 01 256
Nuclei RadialDistribution FracAtD ConA 5of5
Nuclei Intensity MaxIntensity mEGFP-PTEN
Nuclei Granularity 4 DAPI
Nuclei Texture DifferenceEntropy pAKT 5 00 256
RadialDistribution MeanFrac mEGFP-PTEN 1of5
Nuclei Texture InverseDifferenceMoment ConA 10 03 256
Texture SumAverage DAPI 5 02 256
Cytoplasm Texture Correlation ConA 10 01 256
RadialDistribution FracAtD MAP2 2of5
Correlation RWC MAP2 DAPI
Cytoplasm Texture InfoMeas1 ConA 5 03 256
Nuclei Granularity 9 ConA
Cytoplasm Intensity UpperQuartileIntensity MAP2
Cytoplasm Correlation Costes mEGFP-PTEN MAP2
Texture SumAverage ConA 10 03 256
RadialDistribution MeanFrac pAKT 1of5
Granularity 8 mEGFP-PTEN
Nuclei Granularity 8 DAPI
Nuclei Texture SumEntropy ConA 10 02 256
Cytoplasm Intensity UpperQuartileIntensity ConA
Nuclei RadialDistribution MeanFrac MAP2 1of5
Cytoplasm Intensity MinIntensityEdge ConA
Texture DifferenceVariance pAKT 10 01 256
Cytoplasm Texture InfoMeas2 pAKT 20 01 256
Nuclei Correlation RWC MAP2 mEGFP-PTEN
Cytoplasm Correlation Overlap DAPI mEGFP-PTEN
Cytoplasm Texture InverseDifferenceMoment ConA 10 03 256
Nuclei Texture Variance DAPI 10 01 256
Texture DifferenceEntropy mEGFP-PTEN 5 01 256
Granularity 9 mEGFP-PTEN
Granularity 8 ConA
Cytoplasm Texture InfoMeas2 ConA 10 03 256
Nuclei RadialDistribution MeanFrac ConA 1of5
Cytoplasm AreaShape Compactness
Cytoplasm Correlation Correlation DAPI mEGFP-PTEN
Texture InfoMeas1 mEGFP-PTEN 20 03 256
Texture Entropy pAKT 5 03 256
Nuclei Texture SumVariance mEGFP-PTEN 20 03 256
Nuclei Texture Entropy pAKT 10 01 256
Nuclei Texture SumAverage ConA 5 00 256
Granularity 13 DAPI
AreaShape MaxFeretDiameter
Texture Correlation DAPI 10 03 256
Nuclei Texture InverseDifferenceMoment DAPI 5 01 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 10 01 256
Texture DifferenceVariance ConA 5 02 256
Texture Entropy ConA 10 03 256
Texture InverseDifferenceMoment pAKT 20 00 256
Nuclei Granularity 10 MAP2
Cytoplasm Texture InfoMeas2 DAPI 10 00 256
Cytoplasm Texture Entropy DAPI 10 00 256
Cytoplasm Texture InfoMeas1 ConA 20 02 256
Cytoplasm RadialDistribution MeanFrac ConA 2of5
Texture Correlation DAPI 5 00 256
Cytoplasm Texture Entropy pAKT 10 03 256
Nuclei Texture Variance mEGFP-PTEN 20 00 256
Nuclei Texture SumVariance mEGFP-PTEN 10 00 256
Texture DifferenceVariance pAKT 5 00 256
Texture Variance pAKT 5 02 256
Intensity MaxIntensityEdge DAPI
Texture InfoMeas2 ConA 5 03 256
Nuclei Texture SumVariance pAKT 10 02 256
Texture SumVariance DAPI 10 02 256
Nuclei Texture Variance pAKT 20 00 256
Texture InfoMeas1 DAPI 5 00 256
Cytoplasm Texture InfoMeas2 DAPI 20 02 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 5 03 256
Nuclei Granularity 11 DAPI
Cytoplasm Texture InfoMeas2 ConA 20 00 256
Cytoplasm Texture Entropy pAKT 20 00 256
Cytoplasm Correlation Correlation mEGFP-PTEN pAKT
Correlation K mEGFP-PTEN DAPI
Cytoplasm Texture InverseDifferenceMoment ConA 20 02 256
AreaShape Solidity
Nuclei Correlation RWC pAKT mEGFP-PTEN
Texture InverseDifferenceMoment mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 20 01 256
Texture SumVariance mEGFP-PTEN 20 03 256
Nuclei Intensity StdIntensity MAP2
Nuclei Correlation Costes DAPI pAKT
Cytoplasm RadialDistribution FracAtD MAP2 5of5
Nuclei Correlation Overlap DAPI pAKT
Texture Variance mEGFP-PTEN 5 01 256
Nuclei RadialDistribution RadialCV mEGFP-PTEN 4of5
Nuclei Texture Correlation ConA 20 03 256
Nuclei Texture SumEntropy pAKT 20 00 256
Cytoplasm Correlation RWC DAPI mEGFP-PTEN
Texture Correlation DAPI 10 00 256
Nuclei Texture DifferenceVariance DAPI 10 02 256
Cytoplasm Correlation K MAP2 ConA
Cytoplasm Texture Correlation pAKT 5 02 256
Nuclei Granularity 6 MAP2
Nuclei Intensity UpperQuartileIntensity ConA
Intensity MeanIntensity mEGFP-PTEN
Cytoplasm Granularity 3 MAP2
Nuclei Texture SumEntropy pAKT 20 01 256
Texture Contrast mEGFP-PTEN 10 03 256
Intensity MeanIntensityEdge DAPI
Cytoplasm AreaShape MedianRadius
Correlation Manders pAKT DAPI
Correlation RWC mEGFP-PTEN ConA
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 5 03 256
Nuclei RadialDistribution RadialCV pAKT 3of5
Cytoplasm Correlation Correlation mEGFP-PTEN MAP2
Texture SumAverage mEGFP-PTEN 20 03 256
Nuclei Texture Variance pAKT 20 02 256
AreaShape Perimeter
Nuclei Texture DifferenceVariance pAKT 5 00 256
Nuclei Texture InverseDifferenceMoment pAKT 5 02 256
Nuclei Texture Variance mEGFP-PTEN 10 03 256
RadialDistribution FracAtD pAKT 2of5
Nuclei Texture SumAverage ConA 10 03 256
Texture InfoMeas2 ConA 10 00 256
Texture Contrast mEGFP-PTEN 10 02 256
Cytoplasm Correlation Manders ConA DAPI
Texture InfoMeas2 mEGFP-PTEN 10 00 256
Nuclei Texture Correlation MAP2 20 03 256
Cytoplasm Correlation Overlap DAPI pAKT
Nuclei Texture SumAverage pAKT 10 00 256
Cytoplasm Texture InfoMeas1 ConA 10 01 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 20 01 256
Cytoplasm Texture Variance DAPI 10 03 256
Nuclei Granularity 2 pAKT
Nuclei Texture InverseDifferenceMoment DAPI 20 03 256
Nuclei Correlation RWC DAPI pAKT
Nuclei Texture SumVariance DAPI 20 03 256
Cytoplasm Texture DifferenceEntropy DAPI 20 00 256
Cytoplasm Texture Correlation mEGFP-PTEN 5 03 256
Cytoplasm Texture Variance mEGFP-PTEN 10 02 256
Nuclei RadialDistribution FracAtD pAKT 1of5
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 10 03 256
Cytoplasm Correlation RWC pAKT MAP2
Nuclei Granularity 13 DAPI
Texture InverseDifferenceMoment pAKT 5 01 256
Texture InfoMeas2 pAKT 20 03 256
Texture SumEntropy ConA 20 01 256
Cytoplasm Intensity MeanIntensity pAKT
Cytoplasm Intensity IntegratedIntensity ConA
Cytoplasm Texture Contrast DAPI 20 01 256
Nuclei Correlation Correlation DAPI MAP2
Cytoplasm Correlation RWC mEGFP-PTEN pAKT
Nuclei Texture InfoMeas2 ConA 5 00 256
Cytoplasm Texture Correlation DAPI 20 02 256
Cytoplasm Texture InverseDifferenceMoment pAKT 20 00 256
Texture Contrast ConA 5 03 256
Texture DifferenceVariance ConA 5 00 256
Cytoplasm Texture Correlation ConA 5 01 256
Nuclei Texture SumVariance DAPI 10 01 256
Granularity 7 mEGFP-PTEN
Nuclei Texture SumVariance DAPI 20 01 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 20 02 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 20 03 256
RadialDistribution FracAtD pAKT 4of5
Texture DifferenceEntropy pAKT 10 03 256
Nuclei Texture InfoMeas1 pAKT 10 00 256
Cytoplasm Texture Variance ConA 20 00 256
Texture SumEntropy pAKT 5 01 256
Cytoplasm Texture Correlation mEGFP-PTEN 5 00 256
Cytoplasm Texture SumEntropy DAPI 10 00 256
Nuclei Texture Contrast pAKT 20 02 256
Texture InfoMeas1 mEGFP-PTEN 10 03 256
Cytoplasm Intensity StdIntensity mEGFP-PTEN
Correlation RWC DAPI mEGFP-PTEN
Texture SumVariance ConA 5 03 256
Nuclei Texture DifferenceVariance ConA 10 01 256
Texture Contrast pAKT 10 01 256
Nuclei Texture InfoMeas1 DAPI 20 02 256
Nuclei Texture InverseDifferenceMoment DAPI 5 02 256
Cytoplasm RadialDistribution RadialCV mEGFP-PTEN 5of5
Nuclei AreaShape Area
Nuclei Correlation K ConA pAKT
RadialDistribution MeanFrac pAKT 3of5
Nuclei Correlation Costes mEGFP-PTEN pAKT
Nuclei Texture InfoMeas2 pAKT 5 02 256
Texture InfoMeas2 ConA 20 00 256
Cytoplasm Texture Variance DAPI 5 01 256
Nuclei Texture InfoMeas1 pAKT 5 02 256
Texture Contrast DAPI 5 01 256
Texture Entropy pAKT 20 03 256
Nuclei Texture SumVariance pAKT 10 03 256
Cytoplasm Texture InverseDifferenceMoment pAKT 5 02 256
Cytoplasm Correlation Overlap DAPI MAP2
Nuclei Texture Entropy ConA 5 01 256
Texture SumVariance DAPI 20 02 256
Nuclei Texture SumAverage pAKT 5 02 256
Intensity MinIntensityEdge pAKT
Texture Entropy mEGFP-PTEN 20 02 256
Cytoplasm Texture Correlation DAPI 5 03 256
Nuclei Texture SumEntropy pAKT 10 01 256
Cytoplasm Texture Contrast DAPI 5 00 256
Nuclei Texture InverseDifferenceMoment ConA 20 03 256
Intensity MedianIntensity DAPI
Nuclei RadialDistribution RadialCV mEGFP-PTEN 3of5
Nuclei Texture Entropy pAKT 20 00 256
Cytoplasm Granularity 10 DAPI
Texture Correlation mEGFP-PTEN 10 01 256
Granularity 2 ConA
Nuclei Texture Correlation pAKT 5 01 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 5 03 256
Nuclei Texture InverseDifferenceMoment DAPI 5 00 256
Nuclei Correlation Correlation DAPI mEGFP-PTEN
Nuclei Texture InverseDifferenceMoment ConA 10 02 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 5 03 256
Texture Variance ConA 20 02 256
Nuclei Texture Entropy pAKT 10 03 256
RadialDistribution RadialCV MAP2 2of5
Nuclei Texture Correlation DAPI 20 00 256
Nuclei Texture SumEntropy ConA 5 03 256
Nuclei Correlation RWC pAKT DAPI
Cytoplasm Granularity 6 mEGFP-PTEN
Texture SumVariance ConA 5 01 256
Texture Variance ConA 5 03 256
Cytoplasm Texture Correlation pAKT 10 03 256
Cytoplasm Texture SumEntropy ConA 5 02 256
Cytoplasm Correlation K pAKT ConA
Nuclei Texture InfoMeas1 DAPI 20 01 256
Cytoplasm RadialDistribution MeanFrac MAP2 5of5
Nuclei Texture InfoMeas2 DAPI 10 02 256
Cytoplasm Intensity LowerQuartileIntensity MAP2
Nuclei Texture InverseDifferenceMoment DAPI 10 02 256
Cytoplasm Granularity 11 DAPI
Texture DifferenceVariance pAKT 20 02 256
Nuclei Texture Correlation MAP2 20 01 256
Nuclei RadialDistribution RadialCV mEGFP-PTEN 5of5
Cytoplasm Texture Entropy mEGFP-PTEN 10 00 256
Texture SumVariance ConA 20 01 256
Nuclei Texture DifferenceVariance DAPI 20 01 256
Nuclei Texture SumEntropy ConA 5 02 256
Cytoplasm Texture InverseDifferenceMoment ConA 20 00 256
Texture InfoMeas2 ConA 10 01 256
Nuclei Texture Contrast ConA 20 03 256
RadialDistribution MeanFrac ConA 4of5
Texture DifferenceVariance DAPI 10 02 256
Neighbors FirstClosestDistance Adjacent
Cytoplasm Texture SumVariance mEGFP-PTEN 5 02 256
Cytoplasm Intensity IntegratedIntensity mEGFP-PTEN
Cytoplasm Texture InfoMeas1 ConA 20 01 256
Nuclei Texture SumEntropy mEGFP-PTEN 10 02 256
Nuclei Intensity MedianIntensity ConA
Nuclei RadialDistribution RadialCV MAP2 3of5
Nuclei AreaShape Eccentricity
Nuclei Correlation K MAP2 mEGFP-PTEN
Cytoplasm RadialDistribution FracAtD DAPI 5of5
Nuclei Granularity 1 ConA
Granularity 4 pAKT
Nuclei Texture SumAverage mEGFP-PTEN 20 00 256
Granularity 8 MAP2
Texture InfoMeas1 ConA 20 01 256
Texture InfoMeas2 ConA 5 00 256
Cytoplasm AreaShape Extent
Texture DifferenceEntropy DAPI 5 00 256
Cytoplasm Texture Correlation pAKT 10 01 256
Cytoplasm Texture InverseDifferenceMoment DAPI 5 03 256
Nuclei Intensity MinIntensity pAKT
Nuclei Texture Contrast mEGFP-PTEN 10 01 256
Nuclei RadialDistribution FracAtD ConA 1of5
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 10 01 256
Nuclei Intensity MassDisplacement DAPI
Nuclei Texture InfoMeas1 ConA 20 00 256
Nuclei Granularity 9 mEGFP-PTEN
Nuclei Texture Variance ConA 5 01 256
Cytoplasm Intensity MinIntensity ConA
Correlation Manders pAKT ConA
Texture Contrast DAPI 20 01 256
Texture Variance pAKT 5 01 256
Texture Entropy pAKT 20 01 256
Intensity LowerQuartileIntensity pAKT
Texture SumVariance pAKT 10 02 256
Nuclei Texture Correlation pAKT 20 03 256
Texture DifferenceVariance ConA 10 02 256
Cytoplasm RadialDistribution MeanFrac DAPI 1of5
Correlation Correlation DAPI ConA
Cytoplasm Texture DifferenceVariance ConA 5 01 256
AreaShape ConvexArea
Cytoplasm Texture Entropy ConA 10 01 256
Nuclei Texture InverseDifferenceMoment MAP2 20 02 256
Texture SumVariance mEGFP-PTEN 10 03 256
Texture SumAverage mEGFP-PTEN 5 03 256
Texture InfoMeas2 DAPI 20 00 256
Nuclei Texture Variance DAPI 5 03 256
Cytoplasm Texture Entropy ConA 10 03 256
Texture InfoMeas1 DAPI 10 03 256
Nuclei Texture Contrast mEGFP-PTEN 5 01 256
Cytoplasm RadialDistribution MeanFrac DAPI 4of5
Nuclei RadialDistribution MeanFrac mEGFP-PTEN 4of5
Cytoplasm Correlation RWC ConA MAP2
RadialDistribution FracAtD mEGFP-PTEN 1of5
Texture DifferenceEntropy mEGFP-PTEN 5 00 256
Nuclei Texture Contrast DAPI 5 02 256
Texture SumVariance mEGFP-PTEN 10 02 256
Granularity 9 MAP2
Cytoplasm Intensity MaxIntensityEdge MAP2
Cytoplasm RadialDistribution RadialCV DAPI 2of5
Nuclei Texture Contrast pAKT 20 00 256
Nuclei Texture SumAverage pAKT 20 01 256
Nuclei Texture InfoMeas2 DAPI 5 00 256
Nuclei Texture SumAverage DAPI 10 01 256
Nuclei Texture SumVariance DAPI 10 03 256
Cytoplasm RadialDistribution RadialCV MAP2 2of5
Nuclei Texture InfoMeas1 ConA 5 00 256
Cytoplasm Texture SumVariance pAKT 5 01 256
Cytoplasm Texture DifferenceVariance ConA 10 00 256
Texture InfoMeas1 mEGFP-PTEN 10 02 256
Nuclei Texture SumAverage ConA 5 03 256
Texture Contrast DAPI 10 00 256
Texture Correlation DAPI 10 02 256
Nuclei Intensity MinIntensity mEGFP-PTEN
Nuclei Texture Correlation mEGFP-PTEN 10 03 256
Texture InfoMeas2 DAPI 10 00 256
Texture Contrast DAPI 10 02 256
Nuclei Texture InfoMeas1 DAPI 10 02 256
Cytoplasm Texture SumAverage DAPI 10 03 256
Nuclei Texture Contrast ConA 20 00 256
Cytoplasm Texture SumEntropy pAKT 20 02 256
Texture InverseDifferenceMoment DAPI 10 01 256
Cytoplasm Texture SumVariance pAKT 20 03 256
Nuclei Texture Entropy DAPI 20 00 256
Cytoplasm Texture SumEntropy ConA 5 03 256
RadialDistribution RadialCV DAPI 3of5
Texture InfoMeas1 DAPI 10 02 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 20 00 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 20 03 256
Texture SumAverage mEGFP-PTEN 10 03 256
Nuclei Texture Contrast pAKT 5 02 256
Texture Correlation pAKT 10 02 256
Nuclei Texture InfoMeas1 DAPI 5 02 256
Cytoplasm Texture SumAverage pAKT 20 00 256
Nuclei Texture SumEntropy ConA 5 00 256
Nuclei Correlation RWC mEGFP-PTEN DAPI
Nuclei Correlation Correlation mEGFP-PTEN MAP2
Cytoplasm Texture Entropy mEGFP-PTEN 20 03 256
Texture DifferenceVariance mEGFP-PTEN 20 01 256
Cytoplasm Intensity MinIntensityEdge MAP2
Nuclei Intensity MeanIntensityEdge DAPI
Granularity 9 DAPI
RadialDistribution FracAtD DAPI 3of5
AreaShape MinorAxisLength
Cytoplasm Intensity IntegratedIntensityEdge mEGFP-PTEN
Cytoplasm RadialDistribution MeanFrac DAPI 5of5
Texture Entropy pAKT 20 00 256
Correlation RWC ConA MAP2
Texture SumAverage DAPI 5 03 256
RadialDistribution RadialCV DAPI 4of5
Nuclei Granularity 12 mEGFP-PTEN
Texture SumEntropy pAKT 10 00 256
Texture Correlation DAPI 10 01 256
Nuclei Correlation RWC MAP2 ConA
Cytoplasm Texture InfoMeas1 ConA 10 00 256
Nuclei Texture Entropy pAKT 20 01 256
Texture SumAverage ConA 10 02 256
Nuclei Texture Correlation ConA 5 03 256
Nuclei RadialDistribution FracAtD mEGFP-PTEN 4of5
Nuclei Texture Entropy mEGFP-PTEN 5 01 256
Cytoplasm Texture Entropy mEGFP-PTEN 10 03 256
Texture DifferenceVariance mEGFP-PTEN 5 00 256
Cytoplasm Texture SumAverage pAKT 10 00 256
Cytoplasm Texture Variance ConA 10 01 256
Texture Variance DAPI 20 02 256
Nuclei Texture InfoMeas2 ConA 10 01 256
Nuclei Texture InfoMeas2 pAKT 10 03 256
Nuclei Intensity UpperQuartileIntensity pAKT
Nuclei Correlation K MAP2 DAPI
Cytoplasm Correlation Overlap MAP2 pAKT
Nuclei Texture Correlation ConA 10 00 256
Texture Contrast DAPI 20 03 256
Nuclei Granularity 6 DAPI
Nuclei Texture SumEntropy DAPI 20 01 256
Nuclei Intensity StdIntensity mEGFP-PTEN
Nuclei Texture DifferenceVariance pAKT 10 02 256
Texture InverseDifferenceMoment DAPI 20 00 256
Nuclei Intensity MeanIntensityEdge pAKT
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 20 00 256
Nuclei Intensity MinIntensityEdge pAKT
Nuclei Intensity MassDisplacement mEGFP-PTEN
Nuclei AreaShape MaxFeretDiameter
Cytoplasm Texture DifferenceVariance DAPI 5 03 256
Texture Variance DAPI 10 03 256
Cytoplasm Correlation K pAKT mEGFP-PTEN
Cytoplasm Texture InfoMeas1 DAPI 10 03 256
Nuclei Texture InfoMeas1 pAKT 20 00 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 5 02 256
Neighbors PercentTouching Adjacent
Nuclei Texture InverseDifferenceMoment MAP2 20 00 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 5 00 256
Cytoplasm Texture Contrast mEGFP-PTEN 5 00 256
Cytoplasm Granularity 4 MAP2
Correlation Costes DAPI pAKT
Cytoplasm Texture DifferenceEntropy pAKT 20 03 256
Texture SumEntropy DAPI 10 03 256
Texture DifferenceEntropy mEGFP-PTEN 20 03 256
Cytoplasm Correlation K ConA MAP2
Texture InfoMeas2 DAPI 10 02 256
Texture SumEntropy ConA 10 03 256
Nuclei Texture Contrast mEGFP-PTEN 5 03 256
Cytoplasm RadialDistribution MeanFrac ConA 3of5
Nuclei Texture Correlation mEGFP-PTEN 5 01 256
Nuclei RadialDistribution FracAtD DAPI 4of5
Nuclei Texture Correlation ConA 10 03 256
Texture SumEntropy DAPI 5 01 256
Cytoplasm Texture DifferenceEntropy pAKT 5 03 256
Texture SumVariance pAKT 10 00 256
Cytoplasm Texture Correlation DAPI 5 01 256
Cytoplasm Granularity 3 ConA
Nuclei Texture Variance pAKT 5 03 256
Nuclei Texture Contrast pAKT 10 03 256
Cytoplasm Intensity MeanIntensity DAPI
Intensity MinIntensity DAPI
Cytoplasm Texture SumEntropy pAKT 20 01 256
Nuclei Texture Contrast ConA 5 02 256
Nuclei Intensity MinIntensityEdge ConA
Cytoplasm Intensity StdIntensity pAKT
Nuclei Texture InfoMeas2 mEGFP-PTEN 20 00 256
Neighbors FirstClosestDistance 30
Nuclei Correlation Correlation DAPI pAKT
Cytoplasm Texture SumVariance pAKT 10 03 256
Intensity MeanIntensity ConA
Nuclei Texture SumEntropy pAKT 20 02 256
Nuclei Texture SumVariance ConA 10 02 256
Nuclei Texture Correlation mEGFP-PTEN 20 00 256
Correlation RWC mEGFP-PTEN DAPI
Cytoplasm Texture SumVariance mEGFP-PTEN 5 03 256
Nuclei Texture SumAverage ConA 10 01 256
Nuclei RadialDistribution RadialCV MAP2 1of5
Cytoplasm RadialDistribution RadialCV pAKT 3of5
Intensity StdIntensityEdge MAP2
Correlation K ConA MAP2
Texture Entropy DAPI 5 00 256
Nuclei Intensity MeanIntensity DAPI
Nuclei Texture Entropy mEGFP-PTEN 10 02 256
Nuclei Texture InfoMeas2 DAPI 5 01 256
Texture Correlation pAKT 10 00 256
Texture Correlation mEGFP-PTEN 10 03 256
Cytoplasm RadialDistribution MeanFrac pAKT 5of5
Nuclei Granularity 10 DAPI
Texture InfoMeas2 pAKT 10 00 256
Cytoplasm Intensity MeanIntensity ConA
Texture InverseDifferenceMoment ConA 20 00 256
Nuclei RadialDistribution FracAtD MAP2 4of5
RadialDistribution RadialCV pAKT 5of5
Cytoplasm Texture Entropy ConA 20 03 256
Texture DifferenceVariance pAKT 10 03 256
Nuclei Texture InfoMeas2 pAKT 20 00 256
Cytoplasm Texture SumEntropy ConA 20 02 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 20 02 256
Cytoplasm Texture SumVariance mEGFP-PTEN 20 01 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 20 01 256
Cytoplasm Texture SumVariance pAKT 10 00 256
Texture SumEntropy ConA 5 02 256
Cytoplasm Correlation Overlap mEGFP-PTEN pAKT
Nuclei Texture InverseDifferenceMoment pAKT 10 02 256
Nuclei Correlation Overlap mEGFP-PTEN MAP2
Intensity IntegratedIntensityEdge DAPI
Nuclei Intensity StdIntensityEdge pAKT
Nuclei Texture Entropy ConA 20 02 256
Nuclei Texture Contrast DAPI 20 01 256
Nuclei Texture Variance pAKT 20 01 256
Intensity UpperQuartileIntensity mEGFP-PTEN
RadialDistribution RadialCV ConA 1of5
Cytoplasm Texture Contrast pAKT 20 00 256
Texture SumAverage pAKT 10 00 256
Texture SumEntropy ConA 20 02 256
Nuclei Texture SumEntropy mEGFP-PTEN 5 03 256
Nuclei Texture SumEntropy mEGFP-PTEN 20 01 256
Cytoplasm Texture Variance DAPI 20 01 256
Nuclei Texture Correlation ConA 5 02 256
Nuclei Correlation RWC ConA MAP2
Intensity MaxIntensity MAP2
Nuclei Texture Variance mEGFP-PTEN 20 02 256
Nuclei Correlation Correlation pAKT ConA
Nuclei Texture DifferenceEntropy DAPI 5 02 256
Cytoplasm Texture Variance pAKT 5 02 256
Nuclei Texture Variance DAPI 10 00 256
Cytoplasm Texture SumAverage ConA 5 00 256
Cytoplasm Texture SumAverage pAKT 20 03 256
Nuclei Intensity MinIntensityEdge DAPI
Cytoplasm Texture Variance pAKT 5 01 256
RadialDistribution RadialCV ConA 5of5
Cytoplasm Texture Entropy DAPI 5 03 256
Intensity MaxIntensityEdge mEGFP-PTEN
Nuclei Texture Variance mEGFP-PTEN 20 03 256
Correlation Correlation mEGFP-PTEN MAP2
Nuclei Texture Contrast ConA 5 01 256
Cytoplasm Texture Entropy mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas2 pAKT 5 02 256
Texture InfoMeas1 DAPI 5 03 256
Cytoplasm Texture InfoMeas1 ConA 20 03 256
Nuclei Texture DifferenceVariance ConA 20 03 256
Nuclei Texture Entropy DAPI 10 02 256
Texture InfoMeas2 DAPI 20 02 256
Nuclei RadialDistribution FracAtD mEGFP-PTEN 1of5
Nuclei Granularity 1 DAPI
Nuclei Texture InfoMeas1 pAKT 10 02 256
Nuclei Texture Correlation ConA 20 01 256
Nuclei Texture Correlation DAPI 20 01 256
Cytoplasm Texture SumVariance mEGFP-PTEN 10 03 256
Cytoplasm Texture SumEntropy DAPI 5 02 256
Intensity MassDisplacement MAP2
Texture DifferenceVariance ConA 20 00 256
Texture DifferenceVariance pAKT 10 00 256
Nuclei Texture DifferenceVariance ConA 5 01 256
Cytoplasm Texture SumVariance DAPI 10 00 256
Texture DifferenceEntropy ConA 20 01 256
Cytoplasm Texture Contrast ConA 5 00 256
Nuclei Texture Entropy pAKT 20 03 256
Cytoplasm Texture SumAverage DAPI 5 00 256
Granularity 1 MAP2
Cytoplasm Texture Contrast pAKT 5 01 256
Cytoplasm Granularity 7 MAP2
Cytoplasm Texture DifferenceEntropy pAKT 10 02 256
Texture InfoMeas2 pAKT 5 02 256
Cytoplasm Texture SumVariance pAKT 5 02 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 20 02 256
Nuclei Texture InfoMeas1 DAPI 5 03 256
Nuclei RadialDistribution RadialCV DAPI 5of5
Granularity 5 ConA
Nuclei Texture InverseDifferenceMoment pAKT 5 00 256
Texture Correlation mEGFP-PTEN 20 00 256
Texture Variance ConA 5 01 256
Granularity 6 DAPI
Texture Contrast mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas1 pAKT 10 02 256
Texture SumVariance mEGFP-PTEN 20 02 256
Texture SumAverage mEGFP-PTEN 5 00 256
Cytoplasm Texture InfoMeas1 DAPI 10 02 256
Cytoplasm Texture Contrast mEGFP-PTEN 10 01 256
Nuclei Correlation RWC pAKT MAP2
Nuclei Texture InfoMeas1 mEGFP-PTEN 5 01 256
Texture Contrast DAPI 10 01 256
Cytoplasm Correlation Costes DAPI mEGFP-PTEN
Nuclei Texture DifferenceVariance mEGFP-PTEN 5 01 256
Cytoplasm Texture InfoMeas1 pAKT 5 02 256
Cytoplasm Texture InfoMeas2 ConA 5 02 256
Nuclei Texture InverseDifferenceMoment ConA 20 01 256
Nuclei Intensity UpperQuartileIntensity mEGFP-PTEN
Texture InfoMeas1 DAPI 20 03 256
Texture InfoMeas1 DAPI 20 00 256
Cytoplasm Intensity MassDisplacement mEGFP-PTEN
Nuclei RadialDistribution MeanFrac pAKT 1of5
Granularity 9 ConA
AreaShape FormFactor
Cytoplasm Texture SumEntropy pAKT 10 01 256
Cytoplasm Granularity 3 pAKT
Texture InverseDifferenceMoment ConA 10 01 256
Cytoplasm Texture SumEntropy pAKT 5 03 256
AreaShape Compactness
Cytoplasm Correlation RWC DAPI pAKT
Nuclei Texture SumVariance DAPI 20 02 256
Cytoplasm Texture Variance mEGFP-PTEN 20 01 256
Cytoplasm Granularity 5 ConA
Nuclei Texture DifferenceEntropy pAKT 20 00 256
Texture InfoMeas1 pAKT 10 03 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 5 02 256
Texture Contrast pAKT 20 02 256
Nuclei RadialDistribution RadialCV DAPI 1of5
Nuclei Texture DifferenceVariance pAKT 20 03 256
Nuclei Texture Contrast ConA 20 02 256
Cytoplasm Texture Contrast ConA 10 03 256
Cytoplasm Granularity 11 ConA
Cytoplasm Texture SumAverage DAPI 20 00 256
Nuclei Texture SumAverage DAPI 10 03 256
Texture InverseDifferenceMoment DAPI 10 00 256
Cytoplasm Intensity MeanIntensityEdge MAP2
Granularity 6 mEGFP-PTEN
Nuclei Texture SumEntropy mEGFP-PTEN 10 03 256
Nuclei Correlation K MAP2 pAKT
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 10 02 256
Cytoplasm Granularity 1 mEGFP-PTEN
Cytoplasm Texture Entropy mEGFP-PTEN 10 02 256
Texture InfoMeas1 DAPI 20 02 256
Nuclei Texture Variance DAPI 20 00 256
Granularity 12 mEGFP-PTEN
Cytoplasm Correlation Costes DAPI MAP2
Nuclei Texture Variance pAKT 5 02 256
Nuclei Granularity 8 ConA
Cytoplasm Texture Correlation pAKT 5 00 256
Cytoplasm Texture InverseDifferenceMoment pAKT 10 00 256
Nuclei Texture SumAverage pAKT 5 01 256
Texture Variance DAPI 5 01 256
Cytoplasm Texture InfoMeas1 ConA 5 01 256
Nuclei Correlation K ConA mEGFP-PTEN
Cytoplasm Texture SumAverage DAPI 5 03 256
Nuclei Texture Variance DAPI 10 03 256
Texture DifferenceEntropy DAPI 5 01 256
Nuclei RadialDistribution MeanFrac DAPI 2of5
Texture Contrast mEGFP-PTEN 10 01 256
Texture Contrast mEGFP-PTEN 10 00 256
Nuclei Texture SumEntropy pAKT 5 01 256
Cytoplasm Texture InfoMeas2 ConA 20 02 256
Granularity 3 mEGFP-PTEN
Texture InfoMeas1 pAKT 10 02 256
Nuclei Texture DifferenceEntropy ConA 10 02 256
Cytoplasm Texture Entropy ConA 20 00 256
Cytoplasm Texture DifferenceVariance DAPI 20 03 256
Cytoplasm Granularity 7 mEGFP-PTEN
Cytoplasm Granularity 6 ConA
Granularity 3 MAP2
Texture Entropy pAKT 10 03 256
Nuclei Texture SumAverage ConA 10 00 256
Nuclei Texture Variance ConA 5 00 256
Texture SumEntropy mEGFP-PTEN 10 02 256
Cytoplasm Texture Variance mEGFP-PTEN 5 01 256
Cytoplasm Texture SumAverage DAPI 10 02 256
Nuclei RadialDistribution MeanFrac DAPI 4of5
Cytoplasm Granularity 7 ConA
Nuclei Texture InfoMeas2 ConA 20 03 256
Cytoplasm Texture SumEntropy DAPI 5 01 256
Nuclei Texture DifferenceEntropy pAKT 20 03 256
Nuclei Texture Entropy mEGFP-PTEN 20 00 256
Nuclei RadialDistribution MeanFrac pAKT 4of5
Nuclei RadialDistribution MeanFrac mEGFP-PTEN 5of5
Nuclei Texture DifferenceEntropy pAKT 10 00 256
Cytoplasm Texture DifferenceVariance DAPI 10 03 256
Texture SumVariance DAPI 5 00 256
Cytoplasm Texture InfoMeas1 pAKT 20 01 256
Cytoplasm Texture SumVariance DAPI 10 03 256
Nuclei Texture Variance mEGFP-PTEN 10 01 256
Texture InverseDifferenceMoment ConA 20 01 256
Nuclei Texture Variance ConA 10 01 256
Cytoplasm Correlation RWC pAKT mEGFP-PTEN
RadialDistribution RadialCV MAP2 1of5
Texture InfoMeas1 mEGFP-PTEN 5 03 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 5 00 256
Cytoplasm Texture SumEntropy ConA 10 03 256
Nuclei Texture DifferenceVariance MAP2 20 02 256
Nuclei Texture Contrast mEGFP-PTEN 20 00 256
Nuclei Intensity StdIntensity DAPI
Texture InverseDifferenceMoment mEGFP-PTEN 10 01 256
Nuclei RadialDistribution RadialCV ConA 3of5
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 10 03 256
Nuclei Correlation Correlation mEGFP-PTEN pAKT
Cytoplasm Texture SumAverage mEGFP-PTEN 10 03 256
Nuclei Texture Entropy mEGFP-PTEN 20 01 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 10 00 256
Cytoplasm Texture DifferenceEntropy pAKT 10 00 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 5 01 256
Cytoplasm Texture DifferenceEntropy pAKT 5 00 256
Texture Contrast mEGFP-PTEN 20 01 256
Texture InfoMeas2 mEGFP-PTEN 20 00 256
Nuclei Texture DifferenceVariance ConA 20 00 256
Nuclei Granularity 1 pAKT
Nuclei Texture Contrast DAPI 5 03 256
Cytoplasm Granularity 5 mEGFP-PTEN
Nuclei Texture Entropy mEGFP-PTEN 10 01 256
Correlation K DAPI ConA
RadialDistribution FracAtD ConA 1of5
Texture InfoMeas2 ConA 5 02 256
Cytoplasm Texture SumVariance ConA 20 01 256
Nuclei Granularity 3 pAKT
AreaShape Eccentricity
RadialDistribution FracAtD mEGFP-PTEN 2of5
Cytoplasm Intensity MeanIntensity MAP2
Cytoplasm RadialDistribution FracAtD DAPI 1of5
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 20 02 256
Cytoplasm Texture SumEntropy pAKT 5 00 256
Nuclei Texture InfoMeas2 ConA 5 02 256
Cytoplasm Texture Contrast DAPI 5 02 256
Nuclei Texture SumVariance DAPI 5 03 256
Texture InfoMeas1 pAKT 10 01 256
Cytoplasm Intensity MaxIntensityEdge pAKT
Nuclei Granularity 7 ConA
Texture Variance DAPI 20 01 256
Nuclei Granularity 1 mEGFP-PTEN
RadialDistribution FracAtD MAP2 4of5
Cytoplasm Correlation RWC mEGFP-PTEN ConA
Texture Contrast ConA 5 00 256
Nuclei Texture SumAverage MAP2 20 03 256
Nuclei Texture Correlation DAPI 5 00 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 5 02 256
Texture InfoMeas1 pAKT 20 02 256
Cytoplasm Correlation Correlation DAPI pAKT
Correlation RWC pAKT MAP2
Cytoplasm RadialDistribution FracAtD mEGFP-PTEN 2of5
Cytoplasm Texture Contrast pAKT 20 01 256
Texture Variance mEGFP-PTEN 10 01 256
Nuclei Texture Correlation mEGFP-PTEN 5 00 256
Nuclei RadialDistribution RadialCV ConA 1of5
Nuclei Granularity 2 DAPI
Cytoplasm Texture DifferenceVariance pAKT 20 01 256
Intensity MaxIntensityEdge ConA
Cytoplasm Texture Correlation mEGFP-PTEN 20 02 256
Nuclei Texture SumEntropy DAPI 5 03 256
Correlation RWC mEGFP-PTEN pAKT
Nuclei Texture Variance mEGFP-PTEN 5 00 256
Cytoplasm Intensity IntegratedIntensityEdge pAKT
Cytoplasm Texture SumVariance DAPI 10 01 256
Cytoplasm Texture Variance mEGFP-PTEN 5 03 256
Cytoplasm Texture DifferenceVariance DAPI 20 02 256
Cytoplasm Texture SumVariance ConA 10 03 256
Cytoplasm Texture InfoMeas2 DAPI 5 02 256
Cytoplasm Intensity MedianIntensity mEGFP-PTEN
Correlation K ConA pAKT
Texture Correlation pAKT 5 00 256
Texture Correlation DAPI 5 03 256
Texture SumVariance ConA 20 00 256
Texture Contrast DAPI 20 00 256
Texture InverseDifferenceMoment mEGFP-PTEN 10 03 256
AreaShape EquivalentDiameter
Granularity 5 pAKT
Texture Correlation pAKT 10 01 256
Nuclei RadialDistribution FracAtD pAKT 3of5
Cytoplasm Texture SumAverage DAPI 5 02 256
Cytoplasm Texture Correlation pAKT 20 00 256
Texture DifferenceEntropy pAKT 20 00 256
Correlation Correlation DAPI pAKT
Texture InfoMeas2 pAKT 5 01 256
Nuclei Texture DifferenceVariance pAKT 10 03 256
Nuclei Texture SumEntropy ConA 5 01 256
Nuclei Texture Contrast mEGFP-PTEN 10 03 256
Cytoplasm Correlation K pAKT MAP2
Cytoplasm Texture InfoMeas2 pAKT 20 03 256
RadialDistribution FracAtD MAP2 5of5
Nuclei Texture Contrast DAPI 10 01 256
Cytoplasm Texture Correlation DAPI 20 03 256
Nuclei Texture Variance pAKT 5 01 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 10 02 256
Texture DifferenceVariance pAKT 5 03 256
Cytoplasm Texture DifferenceVariance pAKT 5 02 256
Nuclei Texture SumAverage DAPI 5 02 256
Cytoplasm Intensity MassDisplacement ConA
Cytoplasm Correlation RWC pAKT ConA
Correlation Manders DAPI ConA
Correlation Costes MAP2 mEGFP-PTEN
Cytoplasm Intensity StdIntensityEdge mEGFP-PTEN
Cytoplasm Texture SumVariance mEGFP-PTEN 20 03 256
Nuclei Texture InfoMeas1 pAKT 10 03 256
Cytoplasm Texture Contrast DAPI 10 03 256
Cytoplasm Texture SumAverage mEGFP-PTEN 10 01 256
Cytoplasm Intensity MaxIntensity mEGFP-PTEN
Neighbors NumberOfNeighbors 30
Intensity StdIntensityEdge mEGFP-PTEN
Nuclei RadialDistribution FracAtD mEGFP-PTEN 3of5
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 10 03 256
Cytoplasm Correlation RWC ConA pAKT
Nuclei Texture InverseDifferenceMoment DAPI 20 02 256
Texture InverseDifferenceMoment DAPI 20 02 256
Nuclei Correlation K pAKT mEGFP-PTEN
Nuclei Intensity MinIntensity DAPI
Cytoplasm Texture InverseDifferenceMoment ConA 5 03 256
Cytoplasm Texture SumEntropy DAPI 20 03 256
Correlation Costes DAPI mEGFP-PTEN
Texture Entropy mEGFP-PTEN 5 03 256
Nuclei Texture InfoMeas2 mEGFP-PTEN 5 03 256
Cytoplasm RadialDistribution FracAtD DAPI 2of5
Texture Variance mEGFP-PTEN 20 00 256
Nuclei Texture SumVariance mEGFP-PTEN 10 02 256
Cytoplasm Texture SumVariance DAPI 20 03 256
Cytoplasm Texture InfoMeas2 DAPI 5 03 256
Granularity 4 ConA
Texture DifferenceEntropy ConA 10 03 256
Granularity 1 DAPI
Neighbors PercentTouching 30
Nuclei Intensity MADIntensity mEGFP-PTEN
Cytoplasm AreaShape ConvexArea
Nuclei Texture Contrast ConA 10 02 256
Cytoplasm Texture InfoMeas2 pAKT 10 01 256
Texture Correlation DAPI 5 02 256
Texture InverseDifferenceMoment mEGFP-PTEN 20 00 256
Texture Entropy ConA 5 02 256
Cytoplasm Texture Contrast mEGFP-PTEN 5 02 256
Texture SumEntropy pAKT 10 02 256
Granularity 2 MAP2
Correlation Overlap MAP2 ConA
Texture Correlation ConA 20 02 256
Texture InverseDifferenceMoment mEGFP-PTEN 5 00 256
Cytoplasm Texture DifferenceVariance ConA 10 02 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 5 02 256
Texture InverseDifferenceMoment mEGFP-PTEN 10 02 256
RadialDistribution FracAtD pAKT 1of5
Cytoplasm Texture InverseDifferenceMoment ConA 10 00 256
Cytoplasm Texture Variance ConA 20 02 256
Intensity IntegratedIntensityEdge mEGFP-PTEN
Cytoplasm Correlation Overlap MAP2 ConA
Cytoplasm Texture Entropy pAKT 10 02 256
Cytoplasm RadialDistribution MeanFrac MAP2 1of5
Nuclei Texture Correlation mEGFP-PTEN 5 03 256
Nuclei Intensity IntegratedIntensityEdge pAKT
Nuclei Texture Contrast mEGFP-PTEN 20 02 256
Nuclei Intensity MassDisplacement MAP2
Nuclei Correlation RWC MAP2 DAPI
Cytoplasm Texture DifferenceEntropy DAPI 10 02 256
Nuclei RadialDistribution MeanFrac DAPI 3of5
Cytoplasm Texture InfoMeas1 DAPI 20 00 256
Nuclei Texture InfoMeas1 ConA 20 02 256
Texture SumAverage pAKT 20 02 256
Cytoplasm Texture InfoMeas1 DAPI 10 01 256
Nuclei Granularity 3 mEGFP-PTEN
Cytoplasm Texture SumAverage mEGFP-PTEN 5 03 256
Cytoplasm Granularity 12 ConA
Cytoplasm Texture DifferenceEntropy DAPI 5 02 256
Nuclei Texture DifferenceVariance ConA 20 01 256
Nuclei Texture InfoMeas2 ConA 5 03 256
Nuclei Texture InverseDifferenceMoment ConA 10 00 256
Nuclei Texture SumVariance ConA 5 02 256
Nuclei Texture DifferenceVariance MAP2 20 03 256
Nuclei Texture InfoMeas1 pAKT 20 02 256
RadialDistribution MeanFrac ConA 5of5
Nuclei Texture InverseDifferenceMoment pAKT 20 00 256
Nuclei Correlation Overlap DAPI ConA
Texture SumAverage mEGFP-PTEN 10 02 256
Nuclei Texture SumEntropy pAKT 10 03 256
Cytoplasm Granularity 1 MAP2
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 20 00 256
Texture Variance mEGFP-PTEN 10 02 256
Granularity 6 ConA
Nuclei Texture Correlation pAKT 5 03 256
Nuclei Texture DifferenceEntropy pAKT 20 01 256
Texture InfoMeas2 mEGFP-PTEN 20 01 256
Cytoplasm Texture SumVariance DAPI 10 02 256
Cytoplasm Correlation RWC pAKT DAPI
Texture SumVariance DAPI 20 01 256
Nuclei Texture Entropy mEGFP-PTEN 20 02 256
Correlation RWC ConA DAPI
Cytoplasm Texture Variance ConA 5 02 256
Cytoplasm Texture Contrast ConA 10 01 256
Cytoplasm Texture DifferenceVariance pAKT 10 03 256
Nuclei RadialDistribution MeanFrac DAPI 5of5
Texture InfoMeas2 pAKT 5 03 256
Texture DifferenceVariance DAPI 10 03 256
Nuclei Texture DifferenceVariance ConA 20 02 256
Nuclei Texture SumVariance DAPI 5 02 256
Texture InverseDifferenceMoment DAPI 20 01 256
Texture SumAverage DAPI 20 01 256
Cytoplasm RadialDistribution RadialCV ConA 4of5
AreaShape MinFeretDiameter
Texture Correlation ConA 20 00 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 5 03 256
Texture InfoMeas2 DAPI 5 02 256
Cytoplasm Texture Contrast ConA 10 02 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 5 01 256
Intensity StdIntensity ConA
Nuclei Texture Variance ConA 20 00 256
Nuclei Texture DifferenceVariance pAKT 5 02 256
Correlation K pAKT MAP2
Correlation K ConA mEGFP-PTEN
Granularity 11 MAP2
Texture Variance ConA 20 00 256
Nuclei Intensity LowerQuartileIntensity MAP2
Nuclei Texture DifferenceVariance mEGFP-PTEN 10 01 256
Nuclei Texture SumAverage pAKT 20 00 256
Cytoplasm Texture Variance pAKT 5 00 256
Nuclei Texture Variance ConA 10 02 256
Nuclei RadialDistribution FracAtD MAP2 1of5
Correlation Overlap pAKT ConA
Texture Variance mEGFP-PTEN 10 00 256
Nuclei Texture Contrast mEGFP-PTEN 20 03 256
Texture Entropy mEGFP-PTEN 5 02 256
Nuclei Correlation K pAKT ConA
Cytoplasm AreaShape MajorAxisLength
Nuclei Correlation K pAKT MAP2
Texture InfoMeas2 DAPI 10 03 256
Nuclei Texture InfoMeas2 DAPI 20 02 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 5 01 256
Nuclei Texture Entropy DAPI 10 03 256
Texture InfoMeas2 pAKT 20 02 256
Nuclei Texture SumAverage DAPI 10 00 256
Cytoplasm Texture Correlation pAKT 20 01 256
Nuclei Texture Variance ConA 5 02 256
Nuclei Texture InfoMeas1 ConA 10 03 256
Cytoplasm Correlation Costes MAP2 DAPI
Cytoplasm Texture Variance ConA 20 01 256
Nuclei Texture InverseDifferenceMoment pAKT 10 01 256
Texture Contrast DAPI 5 00 256
Texture SumAverage mEGFP-PTEN 20 02 256
Texture SumAverage pAKT 20 00 256
Nuclei Intensity MaxIntensityEdge ConA
Nuclei Texture DifferenceEntropy ConA 5 00 256
Correlation Overlap DAPI MAP2
Nuclei Texture Variance DAPI 5 00 256
Cytoplasm Texture Contrast pAKT 10 00 256
Nuclei Texture InverseDifferenceMoment pAKT 5 01 256
Nuclei Texture InverseDifferenceMoment DAPI 5 03 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 20 01 256
Nuclei Texture InverseDifferenceMoment ConA 20 02 256
Texture InverseDifferenceMoment mEGFP-PTEN 5 01 256
Nuclei Texture SumEntropy mEGFP-PTEN 5 00 256
Nuclei Texture SumEntropy DAPI 20 03 256
Cytoplasm Texture SumAverage DAPI 10 01 256
Cytoplasm RadialDistribution MeanFrac mEGFP-PTEN 2of5
Correlation K DAPI mEGFP-PTEN
Cytoplasm Intensity IntegratedIntensity MAP2
Texture SumAverage ConA 10 01 256
Texture SumVariance pAKT 20 00 256
Nuclei Neighbors AngleBetweenNeighbors 10
Nuclei Texture SumAverage DAPI 5 01 256
AreaShape MajorAxisLength
Granularity 3 DAPI
Cytoplasm Intensity MedianIntensity DAPI
Nuclei Texture Correlation MAP2 20 02 256
Cytoplasm Texture InfoMeas1 pAKT 5 01 256
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 20 03 256
Nuclei Texture Entropy ConA 20 00 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 5 00 256
Nuclei Texture SumVariance ConA 20 00 256
Cytoplasm Correlation RWC MAP2 DAPI
Cytoplasm RadialDistribution FracAtD DAPI 4of5
Nuclei Texture DifferenceVariance DAPI 5 03 256
Correlation Costes pAKT mEGFP-PTEN
Texture Contrast mEGFP-PTEN 5 01 256
Cytoplasm Texture DifferenceVariance pAKT 5 03 256
Nuclei Texture DifferenceVariance pAKT 10 00 256
RadialDistribution MeanFrac MAP2 1of5
Nuclei Texture InfoMeas1 DAPI 5 00 256
Texture InfoMeas1 DAPI 5 02 256
Texture DifferenceEntropy pAKT 10 02 256
Granularity 1 ConA
Texture InfoMeas2 DAPI 5 03 256
Texture Correlation pAKT 20 00 256
Cytoplasm Correlation Costes DAPI pAKT
Nuclei Texture SumEntropy DAPI 20 02 256
Texture DifferenceEntropy ConA 20 02 256
Texture SumVariance mEGFP-PTEN 10 00 256
Cytoplasm Intensity IntegratedIntensity pAKT
Nuclei RadialDistribution FracAtD MAP2 2of5
Cytoplasm Texture SumAverage DAPI 5 01 256
Correlation RWC DAPI pAKT
Cytoplasm Correlation Correlation mEGFP-PTEN ConA
Cytoplasm Texture DifferenceVariance DAPI 10 02 256
Nuclei Texture InfoMeas2 DAPI 10 03 256
Cytoplasm Texture InfoMeas1 DAPI 5 02 256
Cytoplasm Texture Correlation mEGFP-PTEN 10 03 256
Cytoplasm Texture Variance pAKT 20 00 256
Cytoplasm Granularity 12 DAPI
Nuclei Texture SumAverage DAPI 20 00 256
Cytoplasm RadialDistribution MeanFrac ConA 4of5
Cytoplasm RadialDistribution FracAtD pAKT 2of5
Nuclei RadialDistribution MeanFrac mEGFP-PTEN 1of5
Cytoplasm Texture Variance pAKT 20 03 256
Texture InverseDifferenceMoment ConA 10 02 256
Cytoplasm Texture Correlation ConA 10 03 256
Cytoplasm RadialDistribution FracAtD MAP2 4of5
Texture SumEntropy mEGFP-PTEN 5 02 256
Nuclei Texture InfoMeas2 DAPI 10 00 256
Nuclei Texture InfoMeas2 pAKT 20 02 256
Intensity IntegratedIntensity ConA
Cytoplasm Texture InfoMeas1 DAPI 20 02 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 5 03 256
Nuclei Texture SumVariance pAKT 20 03 256
Texture InverseDifferenceMoment mEGFP-PTEN 5 03 256
Cytoplasm Texture DifferenceEntropy ConA 5 00 256
Cytoplasm Texture DifferenceEntropy DAPI 20 03 256
Cytoplasm Texture Correlation ConA 20 00 256
Nuclei Texture Correlation mEGFP-PTEN 20 03 256
Correlation K DAPI pAKT
Cytoplasm Texture InverseDifferenceMoment ConA 20 01 256
Texture DifferenceVariance ConA 10 03 256
Texture Entropy ConA 20 02 256
Cytoplasm Texture Contrast DAPI 10 02 256
Nuclei Correlation RWC MAP2 pAKT
Cytoplasm Texture SumVariance DAPI 5 01 256
Cytoplasm AreaShape Eccentricity
Texture SumVariance ConA 10 01 256
Cytoplasm Texture DifferenceVariance DAPI 20 00 256
Nuclei Texture SumEntropy pAKT 5 03 256
Cytoplasm Texture InverseDifferenceMoment pAKT 5 00 256
Texture Entropy DAPI 5 03 256
Nuclei Texture DifferenceEntropy ConA 20 01 256
Texture InfoMeas2 ConA 10 03 256
Cytoplasm Texture DifferenceVariance ConA 20 00 256
Texture SumEntropy ConA 5 03 256
Texture SumAverage pAKT 5 02 256
Intensity StdIntensity DAPI
Nuclei Texture InverseDifferenceMoment ConA 5 00 256
Nuclei Texture SumEntropy DAPI 5 00 256
Cytoplasm Texture SumEntropy DAPI 5 03 256
Nuclei Texture InfoMeas2 ConA 20 00 256
Nuclei Intensity IntegratedIntensityEdge MAP2
Texture InfoMeas1 mEGFP-PTEN 20 02 256
Cytoplasm Granularity 8 MAP2
RadialDistribution RadialCV mEGFP-PTEN 2of5
Intensity MassDisplacement ConA
Cytoplasm Texture InverseDifferenceMoment DAPI 20 03 256
Texture DifferenceEntropy pAKT 5 01 256
Cytoplasm Texture DifferenceVariance ConA 20 01 256
Texture Variance pAKT 20 00 256
Cytoplasm Texture Entropy pAKT 5 00 256
Cytoplasm Texture InfoMeas1 pAKT 10 03 256
Nuclei Texture DifferenceEntropy DAPI 20 03 256
Texture DifferenceVariance ConA 10 01 256
Cytoplasm Intensity MADIntensity pAKT
Cytoplasm Texture Correlation mEGFP-PTEN 10 02 256
Cytoplasm Texture Variance pAKT 10 01 256
Texture Variance ConA 10 00 256
Nuclei RadialDistribution MeanFrac DAPI 1of5
Cytoplasm Texture SumVariance ConA 20 03 256
Cytoplasm Texture Variance mEGFP-PTEN 5 02 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas2 DAPI 5 00 256
Cytoplasm Texture DifferenceVariance pAKT 20 00 256
Texture Contrast DAPI 5 02 256
RadialDistribution FracAtD DAPI 2of5
Nuclei Texture DifferenceVariance mEGFP-PTEN 20 01 256
Nuclei Texture SumEntropy ConA 10 01 256
Granularity 1 pAKT
Cytoplasm Texture SumAverage ConA 5 03 256
Cytoplasm Texture SumEntropy ConA 20 03 256
Nuclei Intensity IntegratedIntensity ConA
Texture DifferenceEntropy pAKT 20 01 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 5 01 256
Intensity MinIntensityEdge MAP2
Cytoplasm Texture Variance DAPI 5 02 256
Texture InverseDifferenceMoment pAKT 5 03 256
Cytoplasm Intensity MinIntensity DAPI
Cytoplasm Granularity 10 ConA
Nuclei Correlation Overlap DAPI mEGFP-PTEN
Nuclei Texture InfoMeas1 pAKT 5 00 256
Cytoplasm Texture SumEntropy DAPI 20 00 256
Texture Correlation ConA 10 03 256
Cytoplasm Texture InverseDifferenceMoment pAKT 10 03 256
Texture SumAverage DAPI 20 03 256
Cytoplasm Texture DifferenceEntropy ConA 10 00 256
Cytoplasm RadialDistribution RadialCV MAP2 5of5
Texture SumEntropy ConA 10 00 256
Texture DifferenceEntropy pAKT 5 00 256
Texture InfoMeas2 ConA 20 01 256
Texture Entropy mEGFP-PTEN 5 01 256
Cytoplasm Texture InfoMeas1 DAPI 5 00 256
Cytoplasm Granularity 1 ConA
Cytoplasm RadialDistribution MeanFrac ConA 5of5
Nuclei Intensity MedianIntensity pAKT
Texture Correlation pAKT 20 03 256
Nuclei Texture SumAverage pAKT 20 02 256
Texture Variance mEGFP-PTEN 10 03 256
Texture DifferenceEntropy DAPI 20 02 256
Nuclei Texture SumAverage DAPI 5 00 256
Texture SumAverage ConA 10 00 256
Nuclei Texture InfoMeas2 pAKT 5 03 256
Cytoplasm Granularity 9 MAP2
Nuclei Texture DifferenceEntropy mEGFP-PTEN 20 03 256
Cytoplasm Texture Variance DAPI 5 03 256
Cytoplasm RadialDistribution FracAtD ConA 2of5
Cytoplasm Correlation Correlation MAP2 pAKT
Nuclei Texture InverseDifferenceMoment pAKT 5 03 256
Cytoplasm RadialDistribution MeanFrac MAP2 4of5
Texture Correlation ConA 5 01 256
Nuclei Intensity MaxIntensityEdge MAP2
Cytoplasm Texture Variance ConA 5 03 256
Cytoplasm Texture Entropy DAPI 10 01 256
Texture Entropy ConA 10 01 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 10 03 256
Nuclei RadialDistribution MeanFrac MAP2 3of5
Nuclei Texture Contrast ConA 5 00 256
Nuclei Intensity LowerQuartileIntensity DAPI
Cytoplasm Texture SumVariance ConA 5 03 256
Texture SumEntropy DAPI 20 03 256
Cytoplasm Texture InfoMeas2 pAKT 10 03 256
Nuclei Correlation K ConA DAPI
Nuclei Texture SumAverage ConA 20 02 256
Cytoplasm Texture Contrast pAKT 5 03 256
Texture Entropy DAPI 5 01 256
RadialDistribution RadialCV DAPI 2of5
Texture SumAverage DAPI 10 02 256
Cytoplasm Intensity MedianIntensity MAP2
Intensity StdIntensityEdge ConA
Nuclei Texture DifferenceEntropy ConA 20 03 256
Cytoplasm Texture InfoMeas1 mEGFP-PTEN 10 01 256
Intensity UpperQuartileIntensity ConA
Cytoplasm Texture Correlation mEGFP-PTEN 20 00 256
Cytoplasm Texture Contrast ConA 20 02 256
Cytoplasm Texture SumEntropy pAKT 10 03 256
Intensity IntegratedIntensity mEGFP-PTEN
Granularity 5 mEGFP-PTEN
Nuclei Texture SumVariance mEGFP-PTEN 5 00 256
Nuclei Granularity 6 mEGFP-PTEN
Nuclei Texture Entropy ConA 20 01 256
Cytoplasm Texture Correlation DAPI 10 00 256
AreaShape MaximumRadius
Cytoplasm Texture Entropy mEGFP-PTEN 5 02 256
Cytoplasm Intensity MassDisplacement MAP2
Texture Correlation pAKT 10 03 256
Nuclei Texture InverseDifferenceMoment ConA 5 03 256
Cytoplasm Texture SumAverage mEGFP-PTEN 20 03 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 20 03 256
Nuclei Texture InfoMeas1 DAPI 20 03 256
Cytoplasm RadialDistribution RadialCV mEGFP-PTEN 1of5
Texture DifferenceVariance DAPI 5 03 256
Nuclei Correlation RWC mEGFP-PTEN pAKT
Nuclei Texture DifferenceVariance DAPI 20 02 256
RadialDistribution RadialCV pAKT 3of5
Cytoplasm Texture DifferenceEntropy DAPI 10 03 256
Texture SumVariance DAPI 10 01 256
Cytoplasm Texture Entropy pAKT 5 02 256
Cytoplasm RadialDistribution MeanFrac DAPI 3of5
Neighbors SecondClosestDistance 30
Nuclei Texture Entropy pAKT 5 02 256
Cytoplasm Texture DifferenceEntropy DAPI 20 01 256
Cytoplasm RadialDistribution MeanFrac mEGFP-PTEN 4of5
Cytoplasm Texture Variance DAPI 5 00 256
Nuclei Texture Correlation mEGFP-PTEN 20 01 256
Texture Entropy DAPI 10 00 256
Nuclei Intensity LowerQuartileIntensity ConA
Cytoplasm Texture InfoMeas2 ConA 10 00 256
Cytoplasm Texture SumVariance ConA 5 02 256
Texture Variance DAPI 20 00 256
Nuclei Texture InverseDifferenceMoment DAPI 10 03 256
Cytoplasm Correlation K mEGFP-PTEN ConA
Nuclei Texture DifferenceEntropy ConA 5 01 256
Cytoplasm Texture SumEntropy mEGFP-PTEN 10 02 256
Cytoplasm Texture InfoMeas1 DAPI 5 01 256
Nuclei Granularity 3 DAPI
Nuclei Texture InfoMeas1 pAKT 20 03 256
Nuclei Granularity 11 MAP2
Cytoplasm Texture DifferenceVariance pAKT 5 01 256
Nuclei Granularity 11 ConA
Cytoplasm RadialDistribution FracAtD pAKT 1of5
Cytoplasm Texture DifferenceEntropy ConA 10 02 256
Texture Contrast pAKT 20 01 256
Nuclei Intensity MaxIntensity pAKT
Cytoplasm Texture InfoMeas1 pAKT 20 00 256
Texture InfoMeas2 DAPI 10 01 256
Texture InfoMeas1 pAKT 5 01 256
Texture Correlation mEGFP-PTEN 5 01 256
Texture Contrast ConA 20 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 5 01 256
Cytoplasm RadialDistribution MeanFrac DAPI 2of5
Cytoplasm Texture InfoMeas2 pAKT 5 00 256
Texture Variance ConA 20 01 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 10 03 256
Nuclei Texture InverseDifferenceMoment pAKT 10 00 256
Cytoplasm Texture DifferenceVariance DAPI 5 01 256
Nuclei Intensity IntegratedIntensity mEGFP-PTEN
RadialDistribution RadialCV pAKT 1of5
Cytoplasm Texture DifferenceEntropy pAKT 20 01 256
Nuclei Texture Variance mEGFP-PTEN 5 01 256
Nuclei RadialDistribution RadialCV MAP2 2of5
Nuclei Number Object Number
Cytoplasm Correlation Costes mEGFP-PTEN pAKT
Texture Contrast DAPI 10 03 256
Cytoplasm RadialDistribution FracAtD MAP2 2of5
Cytoplasm Correlation K ConA DAPI
Texture Variance DAPI 5 00 256
Texture InverseDifferenceMoment pAKT 20 03 256
Nuclei RadialDistribution FracAtD ConA 4of5
Nuclei RadialDistribution MeanFrac ConA 3of5
Nuclei Texture SumVariance mEGFP-PTEN 10 03 256
RadialDistribution RadialCV MAP2 5of5
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 20 01 256
Cytoplasm Texture Entropy DAPI 5 00 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 20 03 256
Nuclei Texture Correlation DAPI 20 03 256
Correlation RWC MAP2 pAKT
Texture Correlation pAKT 20 02 256
Cytoplasm Texture InverseDifferenceMoment mEGFP-PTEN 20 01 256
Texture SumEntropy ConA 20 00 256
Cytoplasm Texture Entropy pAKT 5 03 256
Nuclei Intensity MADIntensity pAKT
RadialDistribution FracAtD pAKT 5of5
Cytoplasm Texture DifferenceEntropy ConA 5 03 256
Nuclei Texture SumVariance ConA 10 00 256
Nuclei Texture SumEntropy DAPI 20 00 256
Texture SumAverage ConA 5 01 256
Cytoplasm Texture Variance pAKT 5 03 256
Cytoplasm Texture Variance mEGFP-PTEN 10 00 256
Cytoplasm Texture InfoMeas2 DAPI 5 01 256
Nuclei Texture SumAverage DAPI 20 01 256
Cytoplasm Texture Variance mEGFP-PTEN 10 03 256
RadialDistribution MeanFrac ConA 2of5
Texture DifferenceVariance ConA 20 03 256
Intensity LowerQuartileIntensity ConA
Cytoplasm Granularity 4 mEGFP-PTEN
Nuclei Texture SumVariance pAKT 5 01 256
Nuclei Texture InverseDifferenceMoment pAKT 10 03 256
Nuclei Texture SumVariance mEGFP-PTEN 5 01 256
Nuclei Texture Contrast mEGFP-PTEN 5 00 256
Texture SumEntropy DAPI 5 02 256
Correlation RWC mEGFP-PTEN MAP2
Cytoplasm Texture SumVariance pAKT 10 01 256
Nuclei Intensity MaxIntensity MAP2
Nuclei Texture Variance ConA 20 01 256
Cytoplasm Correlation Manders MAP2 DAPI
Texture Entropy pAKT 5 01 256
RadialDistribution MeanFrac MAP2 5of5
Nuclei Texture DifferenceEntropy pAKT 10 02 256
Nuclei Granularity 4 pAKT
Cytoplasm Granularity 6 DAPI
Cytoplasm Texture SumVariance mEGFP-PTEN 5 01 256
Cytoplasm Texture Correlation ConA 5 03 256
Nuclei Correlation K DAPI MAP2
Cytoplasm Texture InverseDifferenceMoment pAKT 10 01 256
Nuclei Texture InfoMeas2 DAPI 5 02 256
Nuclei Intensity MaxIntensityEdge mEGFP-PTEN
RadialDistribution RadialCV DAPI 5of5
Nuclei Intensity StdIntensityEdge mEGFP-PTEN
Nuclei Texture DifferenceEntropy mEGFP-PTEN 10 03 256
Cytoplasm Texture SumVariance mEGFP-PTEN 20 02 256
Nuclei Texture DifferenceEntropy DAPI 10 03 256
Nuclei Texture Contrast mEGFP-PTEN 5 02 256
Nuclei Texture Contrast DAPI 10 02 256
Nuclei Texture SumEntropy ConA 20 03 256
Intensity MinIntensity MAP2
Cytoplasm RadialDistribution FracAtD pAKT 4of5
Cytoplasm Texture Variance pAKT 20 01 256
Nuclei Texture Contrast DAPI 20 03 256
RadialDistribution MeanFrac mEGFP-PTEN 4of5
Cytoplasm Intensity MeanIntensityEdge pAKT
Texture InverseDifferenceMoment DAPI 10 02 256
Texture SumEntropy DAPI 20 01 256
Texture InfoMeas2 ConA 10 02 256
Nuclei AreaShape Solidity
Nuclei Texture Correlation mEGFP-PTEN 5 02 256
Nuclei Texture SumEntropy pAKT 5 02 256
Nuclei Texture DifferenceVariance DAPI 10 01 256
Nuclei Texture Correlation pAKT 10 00 256
Cytoplasm Texture InfoMeas2 pAKT 20 02 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 5 02 256
Nuclei Intensity MinIntensity ConA
Correlation Overlap mEGFP-PTEN pAKT
Texture Correlation mEGFP-PTEN 10 02 256
Nuclei Intensity StdIntensityEdge DAPI
Granularity 4 MAP2
Nuclei Texture DifferenceVariance DAPI 5 01 256
Cytoplasm Correlation Manders MAP2 ConA
Cytoplasm Intensity StdIntensityEdge pAKT
Cytoplasm Granularity 6 pAKT
Cytoplasm Intensity MaxIntensity pAKT
Texture SumEntropy ConA 10 02 256
Nuclei Texture SumAverage pAKT 10 01 256
Cytoplasm Correlation K pAKT DAPI
Texture Variance mEGFP-PTEN 20 03 256
Nuclei Texture SumEntropy pAKT 20 03 256
Cytoplasm Texture DifferenceEntropy mEGFP-PTEN 20 00 256
Cytoplasm Texture Contrast ConA 20 00 256
Cytoplasm Texture Contrast ConA 20 03 256
Cytoplasm Texture Contrast mEGFP-PTEN 10 03 256
Texture Variance ConA 20 03 256
Nuclei Texture Entropy pAKT 20 02 256
Nuclei Intensity IntegratedIntensityEdge DAPI
Texture SumEntropy pAKT 20 00 256
Cytoplasm Texture SumEntropy pAKT 20 00 256
Texture Variance DAPI 5 03 256
Cytoplasm Intensity IntegratedIntensity DAPI
Texture Variance mEGFP-PTEN 5 03 256
Nuclei Texture SumAverage mEGFP-PTEN 20 02 256
Cytoplasm Texture InfoMeas1 pAKT 20 02 256
Texture Entropy pAKT 10 02 256
Cytoplasm AreaShape MinFeretDiameter
Cytoplasm Texture InfoMeas2 mEGFP-PTEN 5 02 256
Nuclei Granularity 12 ConA
Cytoplasm Intensity MedianIntensity ConA
Nuclei RadialDistribution FracAtD DAPI 2of5
Cytoplasm Texture Contrast DAPI 5 03 256
Nuclei Texture DifferenceEntropy mEGFP-PTEN 5 00 256
Nuclei Texture SumAverage MAP2 20 01 256
Granularity 7 ConA
Cytoplasm Texture SumVariance DAPI 20 00 256
Texture SumAverage mEGFP-PTEN 10 01 256
Cytoplasm Correlation Manders mEGFP-PTEN ConA
Intensity MinIntensityEdge DAPI
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 10 02 256
Cytoplasm Texture SumAverage ConA 10 00 256
Cytoplasm Texture InfoMeas2 pAKT 10 02 256
Nuclei Texture Entropy pAKT 10 00 256
Cytoplasm Texture Contrast mEGFP-PTEN 20 01 256
Nuclei Texture InverseDifferenceMoment ConA 5 02 256
Cytoplasm Texture DifferenceVariance mEGFP-PTEN 20 00 256
Nuclei RadialDistribution RadialCV MAP2 4of5
Nuclei RadialDistribution FracAtD mEGFP-PTEN 2of5
Texture SumEntropy DAPI 10 02 256
Nuclei Granularity 8 mEGFP-PTEN
Texture Variance DAPI 20 03 256
Cytoplasm Texture SumVariance pAKT 5 03 256
Cytoplasm Correlation Costes MAP2 mEGFP-PTEN
Correlation K MAP2 ConA
Cytoplasm Texture InfoMeas2 pAKT 5 01 256
Texture Entropy mEGFP-PTEN 20 01 256
Nuclei Texture SumAverage pAKT 10 02 256
Nuclei Granularity 5 pAKT
Nuclei Texture Contrast pAKT 20 03 256
Cytoplasm Texture Contrast pAKT 10 03 256
Nuclei Correlation K pAKT DAPI
Cytoplasm Texture InfoMeas2 DAPI 20 00 256
Nuclei RadialDistribution RadialCV DAPI 3of5
Nuclei Granularity 12 DAPI
Texture InfoMeas2 pAKT 10 03 256
Texture SumAverage pAKT 10 02 256
Granularity 6 pAKT
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 5 02 256
Cytoplasm Texture Entropy ConA 5 01 256
Cytoplasm RadialDistribution RadialCV mEGFP-PTEN 3of5
Texture DifferenceVariance mEGFP-PTEN 5 02 256
Texture Variance mEGFP-PTEN 5 02 256
Nuclei Texture Contrast mEGFP-PTEN 20 01 256
Texture SumAverage pAKT 10 01 256
Texture InfoMeas2 mEGFP-PTEN 5 03 256
Intensity StdIntensityEdge DAPI
Cytoplasm Texture DifferenceVariance ConA 10 01 256
Nuclei Texture SumEntropy DAPI 10 01 256
Cytoplasm RadialDistribution FracAtD mEGFP-PTEN 5of5
Texture DifferenceVariance DAPI 5 01 256
Nuclei Texture Variance mEGFP-PTEN 5 02 256
Nuclei Granularity 4 mEGFP-PTEN
Nuclei Texture InfoMeas2 ConA 10 00 256
Nuclei AreaShape MaximumRadius
ObjectSkeleton NumberBranchEnds ExtSkeleton
Texture DifferenceEntropy pAKT 5 02 256
Texture SumAverage ConA 5 00 256
Nuclei Texture DifferenceEntropy pAKT 5 01 256
Texture SumVariance mEGFP-PTEN 5 03 256
Cytoplasm Texture SumEntropy DAPI 10 01 256
Correlation Overlap MAP2 pAKT
Texture SumEntropy ConA 5 00 256
Nuclei Texture SumVariance DAPI 5 00 256
Texture SumVariance pAKT 5 01 256
Granularity 5 MAP2
Cytoplasm Texture Correlation pAKT 10 00 256
Nuclei Texture InfoMeas2 pAKT 5 01 256
Cytoplasm Texture SumAverage ConA 10 02 256
Nuclei Texture InfoMeas2 DAPI 20 03 256
Nuclei Correlation RWC DAPI mEGFP-PTEN
Texture Contrast pAKT 20 03 256
RadialDistribution RadialCV ConA 3of5
Texture DifferenceEntropy mEGFP-PTEN 20 01 256
Cytoplasm Texture Entropy pAKT 20 01 256
Cytoplasm Intensity MADIntensity MAP2
Nuclei Correlation K DAPI mEGFP-PTEN
Texture Correlation ConA 10 01 256
Nuclei Correlation K mEGFP-PTEN ConA
Cytoplasm Correlation RWC DAPI MAP2
Nuclei Texture DifferenceEntropy ConA 5 02 256
RadialDistribution RadialCV pAKT 4of5
Nuclei Texture InfoMeas2 pAKT 10 00 256
Cytoplasm Texture DifferenceVariance pAKT 10 02 256
Nuclei Texture InfoMeas2 DAPI 10 01 256
Cytoplasm Intensity StdIntensity MAP2
Texture Entropy mEGFP-PTEN 20 03 256
Nuclei Texture SumAverage mEGFP-PTEN 10 00 256
Texture DifferenceEntropy pAKT 10 01 256
Cytoplasm Texture Variance ConA 10 00 256
Cytoplasm Intensity MassDisplacement pAKT
Granularity 3 pAKT
Cytoplasm Texture Correlation ConA 20 02 256
Cytoplasm Correlation RWC ConA mEGFP-PTEN
Granularity 2 DAPI
ObjectSkeleton NumberNonTrunkBranches ExtSkeleton
Cytoplasm Correlation RWC ConA DAPI
Texture InverseDifferenceMoment pAKT 5 00 256
Texture SumEntropy ConA 5 01 256
Nuclei Texture InverseDifferenceMoment mEGFP-PTEN 10 01 256
Nuclei Texture DifferenceVariance ConA 5 02 256
Nuclei Texture DifferenceVariance mEGFP-PTEN 5 03 256
Texture Correlation DAPI 20 02 256
Cytoplasm RadialDistribution MeanFrac mEGFP-PTEN 5of5
Nuclei Texture Contrast pAKT 5 03 256
Cytoplasm Texture DifferenceVariance ConA 20 03 256
Cytoplasm Texture Entropy mEGFP-PTEN 5 01 256
Texture InverseDifferenceMoment pAKT 10 00 256
Texture DifferenceVariance mEGFP-PTEN 10 02 256
Intensity StdIntensity pAKT
Texture InfoMeas2 pAKT 10 01 256
Nuclei Correlation RWC ConA mEGFP-PTEN
Cytoplasm Texture SumEntropy pAKT 20 03 256
Texture SumVariance DAPI 5 02 256
Cytoplasm Texture SumVariance DAPI 5 02 256
Texture DifferenceVariance mEGFP-PTEN 20 02 256
Intensity MassDisplacement pAKT
Texture DifferenceVariance DAPI 20 01 256
Texture Correlation ConA 20 03 256
Cytoplasm Texture Contrast DAPI 10 01 256
Cytoplasm Texture Contrast pAKT 5 00 256
Cytoplasm Texture InfoMeas1 DAPI 10 00 256
Cytoplasm Texture Contrast mEGFP-PTEN 20 02 256
Cytoplasm Intensity MaxIntensity ConA
Nuclei Granularity 3 ConA
Texture Contrast ConA 5 02 256
Cytoplasm Texture Variance DAPI 10 02 256
Cytoplasm Texture Entropy ConA 10 00 256
Texture InverseDifferenceMoment ConA 5 00 256
Cytoplasm Texture InfoMeas2 pAKT 5 03 256
Cytoplasm RadialDistribution MeanFrac pAKT 2of5
Cytoplasm Texture Entropy DAPI 5 02 256
Cytoplasm Texture SumEntropy ConA 10 02 256
Cytoplasm Texture DifferenceVariance DAPI 5 02 256
Texture SumAverage DAPI 10 01 256
Nuclei Granularity 7 DAPI
Cytoplasm Texture SumEntropy ConA 10 01 256
Intensity UpperQuartileIntensity MAP2
Nuclei Texture InfoMeas1 pAKT 20 01 256
Texture DifferenceVariance DAPI 5 02 256
Nuclei Texture InfoMeas1 mEGFP-PTEN 20 02 256
Texture Variance pAKT 20 02 256
Texture DifferenceEntropy DAPI 10 03 256
Cytoplasm Intensity MeanIntensityEdge mEGFP-PTEN
Nuclei RadialDistribution MeanFrac MAP2 4of5
Cytoplasm RadialDistribution RadialCV ConA 2of5
Nuclei Texture SumAverage pAKT 5 03 256
Texture Entropy pAKT 20 02 256
Cytoplasm Texture InverseDifferenceMoment DAPI 10 00 256
Texture Entropy ConA 20 00 256
Nuclei Correlation Overlap MAP2 pAKT
Nuclei Texture DifferenceEntropy mEGFP-PTEN 20 00 256
Nuclei RadialDistribution FracAtD DAPI 5of5
Texture DifferenceEntropy pAKT 20 02 256
50
40
30
20
10
0
-9
-6
-3
0
3
6
9
Feature z-score
Feature: Intensity MeanIntensity mEGFP-PTEN
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161X
D162A
R142K
K125M
H118I
P169A
S170X
V133M
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144X
I168Q
R159I
D153M
D115G
K163X
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
A121D
M134X
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147X
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124X
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165X
I135W
A120D
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169X
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166X
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142X
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
X
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
0
50
100
150
-6
-4
-2
0
2
4
6
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
1.0
10.0
100.0
-6
-4
-2
0
2
4
6
Log scale
Intensity MeanIntensity mEGFP-PTEN
Per variant images
Variant Synonymous
Variant Frameshift
Feature: Intensity MeanIntensity pAKT
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161X
D162A
R142K
K125M
H118I
P169A
S170X
V133M
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144X
I168Q
R159I
D153M
D115G
K163X
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
A121D
M134X
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147X
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124X
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165X
I135W
A120D
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169X
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166X
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142X
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
X
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
0
30
60
90
0
2
4
6
8
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
1.0
10.0
100.0
0
2
4
6
8
Log scale
Intensity MeanIntensity pAKT
Per variant images
Variant Synonymous
Variant Frameshift
Feature: Correlation Correlation DAPI mEGFP-PTEN
D153D
Y138X
S170Y
Q171N
F145X
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122X
C124A
G132H
A121X
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161X
D162A
R142K
K125M
H118I
P169A
S170X
V133M
D153W
D115X
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117X
G143C
H118X
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168X
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119X
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152X
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144X
I168Q
R159I
D153M
D115G
K163X
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116X
K128Q
L139R
A137F
I135X
A120I
G165R
N117S
L112S
L152K
K164V
Q171X
K128G
V158Q
G129F
A121D
M134X
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148X
H118Y
D153F
S170H
A126X
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129X
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164X
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125X
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112X
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131X
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143X
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147X
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124X
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165X
I135W
A120D
C136G
Y155I
A126F
D153X
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133X
R161P
D162X
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150X
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169X
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151X
K128C
V133W
E157P
L140I
T167X
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166X
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154X
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146X
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140X
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136X
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142X
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172X
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139X
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156X
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
X
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
0
20
40
60
80
-6
-3
0
3
6
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138X
Y138X
S170Y
S170Y
Q171N
Q171N
F145X
F145X
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122X
I122X
C124A
C124A
G132H
G132H
A121X
A121X
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161X
R161X
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170X
S170X
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115X
D115X
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117X
N117X
G143C
G143C
H118X
H118X
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168X
I168X
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119X
V119X
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152X
L152X
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144X
K144X
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163X
K163X
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116X
D116X
K128Q
K128Q
L139R
L139R
A137F
A137F
I135X
I135X
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171X
Q171X
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134X
M134X
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148X
A148X
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126X
A126X
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129X
G129X
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124X|K125-
C124X|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164X
K164X
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125X
K125X
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112X
L112X
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131X
T131X
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143X
G143X
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147X
K147X
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124X
C124X
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165X
G165X
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153X
D153X
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133X
V133X
R161P
R161P
D162X
D162X
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150X
E150X
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138X|L139-
Y138X|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169X
P169X
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151X
A151X
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167X
T167X
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136X|A137-
C136X|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166X
V166X
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154X
F154X
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146X
L146X
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140X
L140X
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136X
C136X
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142X
R142X
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172X
R172X
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139X
L139X
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155X|G156-
Y155X|G156-
Y138G
Y138G
G156X
G156X
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
D153*
D*
*D
Nonsense
Cluster 2
Single Missense
*Y
S170*
S*
Cluster 9
*N
Q171*
Q*
Cluster 6
*G
V133*
V*
*V
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
G129*
G*
*E
T160*
T*
Frameshift
Cluster 7
*I
P169*
P*
gnomAD controls
K144*
K*
*R
H141*
H*
*A
C124*
C*
G132*
*H
A151*
A*
*L
A121*
F154*
F*
*Q
V119*
Cluster 1
*W
R161*
R*
Cluster 5
*K
V158*
*P
*F
K125*
G143*
Y138*
Y*
R159*
T131*
A126*
E114*
E*
I135*
I*
G156*
I122*
Cluster 10
A148*
Q149*
D116*
ClinVar: P
G165*
*M
D162*
L152*
L*
L146*
C136*
S113*
*T
T167*
*S
L140*
Y155*
M134*
M*
H118*
I168*
R130*
V166*
H123*
L139*
R142*
*C
F145*
A137*
G127*
K147*
A120*
ClinVar: LB
E150*
D115*
K164*
E157*
L112*
K163*
N117*
N*
K128*
1.0
10.0
-6
-3
0
3
6
Log scale
Correlation Correlation DAPI mEGFP-PTEN
Per variant images
Variant Synonymous
Variant Frameshift
