VISSEQ Data Explorer
About
Lamin A
PTEN iPSC
PTEN Neurons
Data download
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Selected variants
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Use the search bar and the add/remove buttons to select any variants or groups of variants you are interested in. They will show up highlighted in the UMAP and heatmap plots below. When you have made your selections, click the "Update plots" button to reload the page
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Synonymous
Frameshift
3nt Deletion
Nonsense
ClinVar: LP
ClinVar: P
ClinVar: LB
PHTS
ASD/DD
Somatic cancer
gnomAD controls
Cluster 1
Cluster 2
Cluster 3
Cluster 4
Cluster 5
Cluster 6
Cluster 7
Cluster 8
Cluster 9
Cluster 10
Selected features
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Use the search bar and the add/remove buttons to select any cellular features you are interested in. By clicking on individual features they can be selected and removed using the remove button.
Search:
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Intensity MeanIntensity mEGFP-PTEN
Intensity MeanIntensity pAKT
Correlation Correlation DAPI mEGFP-PTEN
Variant UMAP
V119A|A120-
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161*
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170*
V133M
I122I|H123-
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144*
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163*
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
V166fs
A121D
M134*
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153-
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124*|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147*
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124*
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165*
I135W
A120D
R159-
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138*|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169*
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136*|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166*
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142*
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155*|G156-
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
V119A|A120-
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161*
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170*
V133M
I122I|H123-
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144*
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163*
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
V166fs
A121D
M134*
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153-
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124*|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147*
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124*
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165*
I135W
A120D
R159-
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138*|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169*
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136*|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166*
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142*
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155*|G156-
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
V119A|A120-
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161*
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170*
V133M
I122I|H123-
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144*
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163*
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
V166fs
A121D
M134*
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153-
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124*|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147*
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124*
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165*
I135W
A120D
R159-
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138*|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169*
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136*|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166*
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142*
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155*|G156-
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
V119A|A120-
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
Q171fs
P169I
K144R
H141D
F154-
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
K128R|G129-
G143L
R161E
Y138L
R159R
T131D
A126Y
K147fs
A151V
V158H
E114A
I135H
G156G|E157-
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
R159S|T160-
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
K163K|K164-
M134I|I135-
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
V158fs
Y155R
M134W
H118H
A137D|Y138-
I168P
R130M
V133A
G165fs
A148N
R161K
V166Y
M134I
T160H
V166E
V119-
G143A
K125R
T167Q
H123Y
R130fs
I168K
Q149P
H123M
V166K
S170A
G156V
V133fs
F154A
R173fs
K6fs
D162E
K144H
L139G
Y138W
S113R
G127E|K128-
R161*
D162A
Q149Q|E150-
R142K
K125M
H118I
P169A
S170*
V133M
I122I|H123-
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
C136-
G165C
A126G|G127-
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
T167I|I168-
H123I
V133Y
V158-
L146C
K125E
G127V
L139fs
Q149fs
H141A
G143-
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152H|D153-
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
A126A|G127-
F154G
G165L
R142T
A126-
G129K
I168I
E150A
A126A
T160T|R161-
S113K|E114-
Q171P
I168R
K125-
R130F
S170fs
L112R
T131-
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
A137A|Y138-
T131C
K128fs
V119F
L140M
V166A|T167-
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
C136S|A137-
A137-
A151C
K125N|A126-
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R172-
R130A
G129M
R55fs
E114-
T167-
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
T131fs
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
P89fs
H141N
F145L
G132fs
H118L
T160V
T167W
K144*
R172fs
I168Q
R159I
F154Y|Y155-
D153M
D115G
K163*
T167H
M134V
D116M
A121fs
R142D
K164T
K125D
M134F
M134fs
Y155fs
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
V166fs
A121D
M134*
I135fs
Q171Y
N117F
Q171M
T160R
G127H
A148L
A151V|L152-
E150F
E157V
I168fs
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
L146L|K147-
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
R142fs
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153-
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
K125fs
D116E
L146N
F145-
I168W
T160Q
A148E
F154H
R161R
G165G
L152L|D153-
H141I
D116R
D162Q
C136K
D153P
E150G
T160fs
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
L146fs
S113S
H141G
A121-
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
C124*|K125-
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
K163-
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
Q149-
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
H118fs
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
K164K|G165-
L152P
I135Y
I122P
H141Q
G129I
A148T
A126fs
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
K164fs
L139I
G129W
R159fs
A126S
S170M
G156G
R161C
A126G
D116K
H123R|C124-
G156fs
K125N
Q149V
H118E
L139T
Q171R|R172-
K128E
F154S
R142F
G143Y
C124G
E150D|A151-
G156A
G156-
F145P
K163M
R172R
Q171R
A137V
A148fs
S170T
C124S
R159T|T160-
R234fs
G132V
I168V
V166W
K128-
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
H141Q|R142-
I168A
K164L
A151fs
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
Y155W|G156-
L112L|S113-
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
K147K|A148-
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
C124-
E114R
G165E
C124R
T167N
H123D
G127G|K128-
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
R172S|R173-
T131S|G132-
A151W
G156M
L139E
G143G|K144-
K147*
G132R
R172A
H118Q
H123V
W111fs
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
D162fs
C136Y
G143P
C136V
A120P
R130S
A148R
F154F|Y155-
G129-
K125L
D162C
T348fs
K164W
G165S
G156R
G127S
A120F
K144P
K144N|F145-
R130-
H61fs
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
F145L|L146-
T167Y
C124*
R142S
F145fs
K144C
G156W
D153H
T131Q
C124H
T160D
G127fs
V133T
R161N|D162-
Q149G
R142R
Q171S
G132V|V133-
A121A
I122L
M134R
R142I
R130E
S113R|E114-
G165*
I135W
A120D
R159-
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
H141-
D162K
C136fs
C136R
G127A
G132C
K125A
D153fs
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
F56fs
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
K144I|F145-
V166R
I168C
C124C
G127C
V158N
D153I
S113fs
I135F
V166Q
S113Q
R159L
A121I
P169R|S170-
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
Y138*|L139-
N117I
G127T
K128I
Y174fs
A126D
L140L
A126L
T160R|R161-
F145T
Q171-
K128K|G129-
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
H118-
D115D
R159A
L140K
P169*
A151A|L152-
T131W
K125Q
G143V
V166-
M134H
K125T|A126-
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
C136*|A137-
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
K144-
L112Y
P169-
D116D
L140T
S170-
A120R
K147G
V119I
G129G
T160P
S170K|Q171-
A126C
R142G
K128T
L140fs
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122fs
I122M
V166*
E150L
I122N|H123-
Q149M
Y155V
C136S
D115D|D116-
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
H141R|R142-
Y138L|L139-
I168N
Y138E
H141E
R130L
D153L
K144S
P169P|S170-
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
E157V|V158-
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
V133V|M134-
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G165-
G156L
R142W
T321fs
I135C
V166G
C124E
L140-
A148S
K144fs
C124K
K147W
G127D
L152W
K147D
F154fs
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
H123H|C124-
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
G143fs
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
R142R|G143-
G132-
G165N
V158G|R159-
I135I|C136-
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
S170R|Q171-
D116W
D116G
Q149Q
D162E|K163-
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
L152fs
R159H
E288fs
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
I168T|P169-
E157fs
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
I122-
T160F
R172V
M134-
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
A120fs
E157A
V119L
R159V
L112fs
L152S
Y155M
Q171W
R172S
D116D|N117-
A137I
A120L
E114D|D115-
V133P
H141fs
R142*
N117T
G156E|E157-
K147T|A148-
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E150fs
E157K
P169F
H123E
P169W
V158G
H118F
R161fs
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
R161S|D162-
L152N
K128P
L139N
D115W
I135S
G165V|V166-
I135K
H141C
I122W
T167fs
K163E
I135M
T131H
V133Q
Y155*|G156-
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
L265fs
K164M
V119H
F154V
A151M
I168-
G127E
C136P
R159P
Q149S
P169fs
I122Y
F154D
D162-
H123T
V133G
D162F
-9
-6
-3
0
3
6
9
Color UMAP plot by:
None
Intensity MeanIntensity mEGFP-PTEN
Intensity MeanIntensity pAKT
Correlation Correlation DAPI mEGFP-PTEN
Randomly selected cell images
Variant: Synonymous
Variant: Frameshift
Feature: Intensity MeanIntensity mEGFP-PTEN
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161*
D162A
R142K
K125M
H118I
P169A
S170*
V133M
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144*
I168Q
R159I
D153M
D115G
K163*
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
A121D
M134*
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147*
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124*
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165*
I135W
A120D
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169*
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166*
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142*
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
*
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
0
50
100
150
-6
-4
-2
0
2
4
6
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
1.0
10.0
100.0
-6
-4
-2
0
2
4
6
Log scale
Intensity MeanIntensity mEGFP-PTEN
Per variant images
Variant Synonymous
Variant Frameshift
Feature: Intensity MeanIntensity pAKT
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161*
D162A
R142K
K125M
H118I
P169A
S170*
V133M
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144*
I168Q
R159I
D153M
D115G
K163*
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
A121D
M134*
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147*
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124*
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165*
I135W
A120D
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169*
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166*
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142*
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
*
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
0
30
60
90
0
2
4
6
8
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
1.0
10.0
100.0
0
2
4
6
8
Log scale
Intensity MeanIntensity pAKT
Per variant images
Variant Synonymous
Variant Frameshift
Feature: Correlation Correlation DAPI mEGFP-PTEN
D153D
Y138*
S170Y
Q171N
F145*
Q171G
V133V
G129E
T160E
P169I
K144R
H141D
S170D
I122*
C124A
G132H
A121*
A151L
A121Y
F154Q
V119D
R161W
D153K
G132Q
G129L
V158P
K125F
G143L
R161E
Y138L
R159R
T131D
A126Y
A151V
V158H
E114A
I135H
G156E
I122Q
A148A
Q149H
S170K
D116L
S170I
G165K
D162M
L152M
G165Y
L146K
A151P
C136Q
G156I
S113T
S113W
C136N
R172E
A121T
L146L
I122R
G165A
I122E
I135A
T167L
S113N
E114V
T131S
L140H
Y155R
M134W
H118H
I168P
R130M
V133A
A148N
R161K
V166Y
M134I
T160H
V166E
G143A
K125R
T167Q
H123Y
I168K
Q149P
H123M
V166K
S170A
G156V
F154A
D162E
K144H
L139G
Y138W
S113R
R161*
D162A
R142K
K125M
H118I
P169A
S170*
V133M
D153W
D115*
L139A
Y155S
H141P
R172I
G132D
R161H
L146I
N117*
G143C
H118*
E114C
G165C
F145F
K125W
L139H
T160G
C124M
A137Q
Q149W
I168*
H123I
V133Y
L146C
K125E
G127V
H141A
K147M
R142A
K147N
V119*
Y138R
A120V
T131P
L140S
Y138A
C136C
G165Q
V158W
H141T
R142Q
E150H
G143D
Y155P
K147I
Y155W
D115A
L146G
L152Y
A148F
A151A
A137T
K164H
R159N
K125C
D116Q
A120M
L152F
R159D
E157N
F154G
G165L
R142T
G129K
I168I
E150A
A126A
Q171P
I168R
R130F
L112R
C124F
L139Y
D162R
R130T
L139M
A126I
V133N
D162L
T131C
V119F
L140M
A120C
L152*
Y138M
R161Q
K144F
A120S
L112I
D115P
L139D
R142H
E114L
G127M
V119K
D116T
P169K
T160N
A151C
E114F
Q149D
Y138P
K163C
C124L
I168T
H123L
K147Q
D153E
Y138I
R161L
R130A
G129M
T131L
R161F
K163F
C136T
I122H
N117N
G129C
A120T
R142L
R161D
L152E
V119P
S170Q
D115Y
T167A
D115Q
G143F
E157L
H141N
F145L
H118L
T160V
T167W
K144*
I168Q
R159I
D153M
D115G
K163*
T167H
M134V
D116M
R142D
K164T
K125D
M134F
Y138T
D115M
Y155C
R159F
C136D
H118D
D115H
P169C
E157S
H123K
I122F
E114K
A148K
D116*
K128Q
L139R
A137F
I135*
A120I
G165R
N117S
L112S
L152K
K164V
Q171*
K128G
V158Q
G129F
A121D
M134*
Q171Y
N117F
Q171M
T160R
G127H
A148L
E150F
E157V
K128S
A137S
T160I
Y155K
H123P
L152R
A137N
P169L
E114S
V133R
A121F
S170C
V166S
Y138S
D153V
M134S
K163S
E114I
H118R
T160K
H118T
G129Y
L112C
V158S
R172H
I135Q
R161N
G129H
G165D
N117M
R130I
I135G
A148I
R159W
V158D
L139V
P169Y
C124P
D116N
A148*
H118Y
D153F
S170H
A126*
L146P
I168G
L139P
I135D
F154L
C124D
D116E
L146N
I168W
T160Q
A148E
F154H
R161R
G165G
H141I
D116R
D162Q
C136K
D153P
E150G
V133E
V166A
G156T
C136A
H123G
T167C
A121R
K144Y
T160Y
V166V
G129*
H141H
A137K
Q149Y
L140W
K128M
G165V
K147F
S113S
H141G
D153T
Q171E
A120W
F145H
K163W
A148P
G129P
T131G
A137Y
T131E
R130P
R172F
K125G
T160W
P169G
K163V
V158V
D116A
C136I
A126N
A137L
R161S
V166D
L140A
F145D
T131F
Q171F
I122A
R172K
A126W
L140D
L146T
L146Q
A151R
A121C
G156Y
G127I
F154I
R130K
H123H
G165F
K125V
H141K
K163T
L139C
H118P
M134E
T131Y
V133I
E150P
R159T
Q171C
E157I
K164*
D153G
G132N
T160M
R130C
V166M
C124Y
Q149C
A151N
T131T
I135P
K144M
A121E
K125Y
T167K
R172M
A121H
F154F
E150Q
K125*
G165T
A148W
G143G
L139Q
Y138H
V158F
C124V
N117R
F145Q
R130H
K164E
L146R
H123N
D115C
L152P
I135Y
I122P
H141Q
G129I
A148T
T167S
E114Y
D162V
D153N
I168F
R130W
K147H
I122I
D153A
C136F
G127K
L140R
Y155G
L112*
D116I
T167E
L112V
L146S
E157W
L139I
G129W
A126S
S170M
G156G
R161C
A126G
D116K
K125N
Q149V
H118E
L139T
K128E
F154S
R142F
G143Y
C124G
G156A
F145P
K163M
R172R
Q171R
A137V
S170T
C124S
G132V
I168V
V166W
I135V
V133S
A137R
A148M
K128R
T131*
A126M
A120G
A121V
L146M
H123R
E114H
I168A
K164L
A120K
M134L
G156H
V158A
D115F
R159Q
S170F
A126V
L152A
P169E
L112F
K125P
P169V
L112L
E150Y
G129V
V119S
K144I
P169S
L152D
K128F
R142V
E157T
I168Y
Q171D
D115I
V158Y
K144E
E114P
E157F
V158I
H118M
G127P
T167P
G143*
D162W
A151G
T167I
N117Y
D116Y
L152L
G132P
D153Q
S113I
I168H
G132E
Q149I
K128L
Y138V
Q149F
V166F
E114R
G165E
C124R
T167N
H123D
E150I
A120N
V133C
P169R
E114Q
A148D
P169P
C136W
E114D
G132Y
A151W
G156M
L139E
K147*
G132R
R172A
H118Q
H123V
A151D
F145S
R172L
I122N
C124I
Y155E
Q149A
K128N
R161M
L140Q
L152H
H141W
G127R
C136Y
G143P
C136V
A120P
R130S
A148R
K125L
D162C
K164W
G165S
G156R
G127S
A120F
K144P
C124T
L112A
Y138N
K164I
V158M
T167F
D115N
L112K
M134Q
M134C
R161Y
F154T
T167Y
C124*
R142S
K144C
G156W
D153H
T131Q
C124H
T160D
V133T
Q149G
R142R
Q171S
A121A
I122L
M134R
R142I
R130E
G165*
I135W
A120D
C136G
Y155I
A126F
D153*
A137E
Y155Y
G156N
H123W
D153C
D116H
A120E
A121W
A121K
H118W
F154R
D162P
V133*
R161P
D162*
L146W
Y138Q
L139F
V133L
T167M
L146A
A121G
D162K
C136R
G127A
G132C
K125A
D162N
L112Q
R159Y
G143H
D116F
G127L
E150*
V133H
A137G
V119W
D162G
A120Q
G132F
L146F
H118N
A151Q
V119R
A126Q
D162H
H118V
K164D
Y155F
C136E
F154P
K144K
V166R
I168C
C124C
G127C
V158N
D153I
I135F
V166Q
S113Q
R159L
A121I
E157M
V166C
I135R
A151E
H141S
R161A
R142M
K144T
N117I
G127T
K128I
A126D
L140L
A126L
F145T
R130Q
R161T
F145E
R159G
F154K
E157H
A148Q
K125K
Y155A
V119T
A137C
D115D
R159A
L140K
P169*
T131W
K125Q
G143V
M134H
I122K
K147R
K164A
K144V
A151*
K128C
V133W
E157P
L140I
T167*
E150D
L152Q
R172Y
A151H
A121S
K144W
R172C
K128V
S113H
T167G
K164S
L146D
S113Y
I168D
L112Y
D116D
L140T
A120R
K147G
V119I
G129G
T160P
A126C
R142G
K128T
Q171K
I135E
L146V
I168E
Y155L
A148Y
I122M
V166*
E150L
Q149M
Y155V
C136S
H123C
Y155T
Q171H
D115R
L152G
F154Y
C136M
I168N
Y138E
H141E
R130L
D153L
K144S
Q149K
L152I
E114M
C136H
L140F
G156P
F145Y
D115S
D115E
F145G
L140V
K164Y
E150N
Y155H
N117K
L139W
A148G
K163K
Q149L
F154*
G143R
F154M
A137P
A120Y
S170E
V119Q
F154E
V166I
D162T
G156L
R142W
I135C
V166G
C124E
A148S
C124K
K147W
G127D
L152W
K147D
H141F
K125H
L140P
L112M
V166L
L146*
S170W
G132S
G132T
N117P
V166P
G143M
K128W
S113F
G143N
V119N
K164N
A137H
S113D
K144N
K128A
I122S
F145M
K163Y
I122C
A151K
K128D
N117E
S113P
T131I
R159M
F154W
V119V
K144Q
A137A
I122T
K147T
G132A
K144D
M134T
R130N
S170G
H141R
E157E
F145V
K147S
K147L
Q149T
I135N
R130R
L140*
G165I
E157D
Q171T
R130D
E150K
R159S
K128K
I168L
G165N
E114E
L112D
R142E
H118K
R130Y
S170P
L140G
D116W
D116G
Q149Q
G156C
D162D
D153Y
G129Q
R172G
K164P
K164G
R159H
V158T
D162S
S170V
T131R
K163A
M134N
D116C
L140C
N117A
Q171L
D115L
Y138C
H123Q
F154C
P169H
T160C
H118G
F145C
L139K
T160F
R172V
S170N
L112N
K147Y
T160A
V119A
Q171I
V158E
E157C
C136*
G165H
E157A
V119L
R159V
L152S
Y155M
Q171W
R172S
A137I
A120L
V133P
R142*
N117T
F145A
E150V
L146Y
Q171Q
G127W
K164R
K147C
K144L
G143T
R172N
G132I
R172*
D162I
E114G
P169Q
A137D
E157K
P169F
H123E
P169W
V158G
H118F
L140E
Q149N
Y155Q
M134A
P169T
T131M
R142N
G156D
L139*
A151S
V133D
R161I
E157G
G143I
G132K
L152N
K128P
L139N
D115W
I135S
I135K
H141C
I122W
K163E
I135M
T131H
V133Q
Y138G
G156*
K164F
A137W
D116P
L146E
D116V
K164M
V119H
F154V
A151M
G127E
C136P
R159P
Q149S
I122Y
F154D
H123T
V133G
D162F
115
120
125
130
135
140
145
150
155
160
165
170
A
V
I
L
G
F
Y
W
C
M
P
S
T
N
Q
D
E
H
K
R
*
-9
-6
-3
0
3
6
9
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
0
20
40
60
80
-6
-3
0
3
6
External link
V119A|A120-
V119A|A120-
D153D
D153D
Y138*
Y138*
S170Y
S170Y
Q171N
Q171N
F145*
F145*
Q171G
Q171G
V133V
V133V
G129E
G129E
T160E
T160E
Q171fs
Q171fs
P169I
P169I
K144R
K144R
H141D
H141D
F154-
F154-
S170D
S170D
I122*
I122*
C124A
C124A
G132H
G132H
A121*
A121*
A151L
A151L
A121Y
A121Y
F154Q
F154Q
V119D
V119D
R161W
R161W
D153K
D153K
G132Q
G132Q
G129L
G129L
V158P
V158P
K125F
K125F
K128R|G129-
K128R|G129-
G143L
G143L
R161E
R161E
Y138L
Y138L
R159R
R159R
T131D
T131D
A126Y
A126Y
K147fs
K147fs
A151V
A151V
V158H
V158H
E114A
E114A
I135H
I135H
G156G|E157-
G156G|E157-
G156E
G156E
I122Q
I122Q
A148A
A148A
Q149H
Q149H
S170K
S170K
D116L
D116L
S170I
S170I
G165K
G165K
D162M
D162M
R159S|T160-
R159S|T160-
L152M
L152M
G165Y
G165Y
L146K
L146K
A151P
A151P
C136Q
C136Q
G156I
G156I
S113T
S113T
S113W
S113W
C136N
C136N
K163K|K164-
K163K|K164-
M134I|I135-
M134I|I135-
R172E
R172E
A121T
A121T
L146L
L146L
I122R
I122R
G165A
G165A
I122E
I122E
I135A
I135A
T167L
T167L
S113N
S113N
E114V
E114V
T131S
T131S
L140H
L140H
V158fs
V158fs
Y155R
Y155R
M134W
M134W
H118H
H118H
A137D|Y138-
A137D|Y138-
I168P
I168P
R130M
R130M
V133A
V133A
G165fs
G165fs
A148N
A148N
R161K
R161K
V166Y
V166Y
M134I
M134I
T160H
T160H
V166E
V166E
V119-
V119-
G143A
G143A
K125R
K125R
T167Q
T167Q
H123Y
H123Y
R130fs
R130fs
I168K
I168K
Q149P
Q149P
H123M
H123M
V166K
V166K
S170A
S170A
G156V
G156V
V133fs
V133fs
F154A
F154A
R173fs
R173fs
K6fs
K6fs
D162E
D162E
K144H
K144H
L139G
L139G
Y138W
Y138W
S113R
S113R
G127E|K128-
G127E|K128-
R161*
R161*
D162A
D162A
Q149Q|E150-
Q149Q|E150-
R142K
R142K
K125M
K125M
H118I
H118I
P169A
P169A
S170*
S170*
V133M
V133M
I122I|H123-
I122I|H123-
D153W
D153W
D115*
D115*
L139A
L139A
Y155S
Y155S
H141P
H141P
R172I
R172I
G132D
G132D
R161H
R161H
L146I
L146I
N117*
N117*
G143C
G143C
H118*
H118*
E114C
E114C
C136-
C136-
G165C
G165C
A126G|G127-
A126G|G127-
F145F
F145F
K125W
K125W
L139H
L139H
T160G
T160G
C124M
C124M
A137Q
A137Q
Q149W
Q149W
I168*
I168*
T167I|I168-
T167I|I168-
H123I
H123I
V133Y
V133Y
V158-
V158-
L146C
L146C
K125E
K125E
G127V
G127V
L139fs
L139fs
Q149fs
Q149fs
H141A
H141A
G143-
G143-
K147M
K147M
R142A
R142A
K147N
K147N
V119*
V119*
Y138R
Y138R
A120V
A120V
T131P
T131P
L140S
L140S
Y138A
Y138A
C136C
C136C
G165Q
G165Q
V158W
V158W
H141T
H141T
R142Q
R142Q
E150H
E150H
G143D
G143D
Y155P
Y155P
K147I
K147I
Y155W
Y155W
D115A
D115A
L146G
L146G
L152H|D153-
L152H|D153-
L152Y
L152Y
A148F
A148F
A151A
A151A
A137T
A137T
K164H
K164H
R159N
R159N
K125C
K125C
D116Q
D116Q
A120M
A120M
L152F
L152F
R159D
R159D
E157N
E157N
A126A|G127-
A126A|G127-
F154G
F154G
G165L
G165L
R142T
R142T
A126-
A126-
G129K
G129K
I168I
I168I
E150A
E150A
A126A
A126A
T160T|R161-
T160T|R161-
S113K|E114-
S113K|E114-
Q171P
Q171P
I168R
I168R
K125-
K125-
R130F
R130F
S170fs
S170fs
L112R
L112R
T131-
T131-
C124F
C124F
L139Y
L139Y
D162R
D162R
R130T
R130T
L139M
L139M
A126I
A126I
V133N
V133N
D162L
D162L
A137A|Y138-
A137A|Y138-
T131C
T131C
K128fs
K128fs
V119F
V119F
L140M
L140M
V166A|T167-
V166A|T167-
A120C
A120C
L152*
L152*
Y138M
Y138M
R161Q
R161Q
K144F
K144F
A120S
A120S
L112I
L112I
D115P
D115P
L139D
L139D
R142H
R142H
E114L
E114L
G127M
G127M
V119K
V119K
D116T
D116T
P169K
P169K
T160N
T160N
C136S|A137-
C136S|A137-
A137-
A137-
A151C
A151C
K125N|A126-
K125N|A126-
E114F
E114F
Q149D
Q149D
Y138P
Y138P
K163C
K163C
C124L
C124L
I168T
I168T
H123L
H123L
K147Q
K147Q
D153E
D153E
Y138I
Y138I
R161L
R161L
R172-
R172-
R130A
R130A
G129M
G129M
R55fs
R55fs
E114-
E114-
T167-
T167-
T131L
T131L
R161F
R161F
K163F
K163F
C136T
C136T
I122H
I122H
N117N
N117N
G129C
G129C
A120T
A120T
R142L
R142L
R161D
R161D
L152E
L152E
T131fs
T131fs
V119P
V119P
S170Q
S170Q
D115Y
D115Y
T167A
T167A
D115Q
D115Q
G143F
G143F
E157L
E157L
P89fs
P89fs
H141N
H141N
F145L
F145L
G132fs
G132fs
H118L
H118L
T160V
T160V
T167W
T167W
K144*
K144*
R172fs
R172fs
I168Q
I168Q
R159I
R159I
F154Y|Y155-
F154Y|Y155-
D153M
D153M
D115G
D115G
K163*
K163*
T167H
T167H
M134V
M134V
D116M
D116M
A121fs
A121fs
R142D
R142D
K164T
K164T
K125D
K125D
M134F
M134F
M134fs
M134fs
Y155fs
Y155fs
Y138T
Y138T
D115M
D115M
Y155C
Y155C
R159F
R159F
C136D
C136D
H118D
H118D
D115H
D115H
P169C
P169C
E157S
E157S
H123K
H123K
I122F
I122F
E114K
E114K
A148K
A148K
D116*
D116*
K128Q
K128Q
L139R
L139R
A137F
A137F
I135*
I135*
A120I
A120I
G165R
G165R
N117S
N117S
L112S
L112S
L152K
L152K
K164V
K164V
Q171*
Q171*
K128G
K128G
V158Q
V158Q
G129F
G129F
V166fs
V166fs
A121D
A121D
M134*
M134*
I135fs
I135fs
Q171Y
Q171Y
N117F
N117F
Q171M
Q171M
T160R
T160R
G127H
G127H
A148L
A148L
A151V|L152-
A151V|L152-
E150F
E150F
E157V
E157V
I168fs
I168fs
K128S
K128S
A137S
A137S
T160I
T160I
Y155K
Y155K
H123P
H123P
L152R
L152R
A137N
A137N
P169L
P169L
E114S
E114S
V133R
V133R
A121F
A121F
S170C
S170C
V166S
V166S
Y138S
Y138S
L146L|K147-
L146L|K147-
D153V
D153V
M134S
M134S
K163S
K163S
E114I
E114I
H118R
H118R
T160K
T160K
H118T
H118T
G129Y
G129Y
L112C
L112C
V158S
V158S
R172H
R172H
I135Q
I135Q
R161N
R161N
G129H
G129H
G165D
G165D
N117M
N117M
R130I
R130I
I135G
I135G
R142fs
R142fs
A148I
A148I
R159W
R159W
V158D
V158D
L139V
L139V
P169Y
P169Y
C124P
C124P
D116N
D116N
A148*
A148*
H118Y
H118Y
D153-
D153-
D153F
D153F
S170H
S170H
A126*
A126*
L146P
L146P
I168G
I168G
L139P
L139P
I135D
I135D
F154L
F154L
C124D
C124D
K125fs
K125fs
D116E
D116E
L146N
L146N
F145-
F145-
I168W
I168W
T160Q
T160Q
A148E
A148E
F154H
F154H
R161R
R161R
G165G
G165G
L152L|D153-
L152L|D153-
H141I
H141I
D116R
D116R
D162Q
D162Q
C136K
C136K
D153P
D153P
E150G
E150G
T160fs
T160fs
V133E
V133E
V166A
V166A
G156T
G156T
C136A
C136A
H123G
H123G
T167C
T167C
A121R
A121R
K144Y
K144Y
T160Y
T160Y
V166V
V166V
G129*
G129*
H141H
H141H
A137K
A137K
Q149Y
Q149Y
L140W
L140W
K128M
K128M
G165V
G165V
K147F
K147F
L146fs
L146fs
S113S
S113S
H141G
H141G
A121-
A121-
D153T
D153T
Q171E
Q171E
A120W
A120W
F145H
F145H
K163W
K163W
A148P
A148P
G129P
G129P
T131G
T131G
A137Y
A137Y
T131E
T131E
R130P
R130P
R172F
R172F
K125G
K125G
T160W
T160W
P169G
P169G
K163V
K163V
V158V
V158V
D116A
D116A
C136I
C136I
C124*|K125-
C124*|K125-
A126N
A126N
A137L
A137L
R161S
R161S
V166D
V166D
L140A
L140A
F145D
F145D
T131F
T131F
Q171F
Q171F
I122A
I122A
K163-
K163-
R172K
R172K
A126W
A126W
L140D
L140D
L146T
L146T
L146Q
L146Q
A151R
A151R
A121C
A121C
G156Y
G156Y
G127I
G127I
F154I
F154I
R130K
R130K
H123H
H123H
G165F
G165F
K125V
K125V
H141K
H141K
K163T
K163T
L139C
L139C
Q149-
Q149-
H118P
H118P
M134E
M134E
T131Y
T131Y
V133I
V133I
E150P
E150P
R159T
R159T
Q171C
Q171C
E157I
E157I
K164*
K164*
H118fs
H118fs
D153G
D153G
G132N
G132N
T160M
T160M
R130C
R130C
V166M
V166M
C124Y
C124Y
Q149C
Q149C
A151N
A151N
T131T
T131T
I135P
I135P
K144M
K144M
A121E
A121E
K125Y
K125Y
T167K
T167K
R172M
R172M
A121H
A121H
F154F
F154F
E150Q
E150Q
K125*
K125*
G165T
G165T
A148W
A148W
G143G
G143G
L139Q
L139Q
Y138H
Y138H
V158F
V158F
C124V
C124V
N117R
N117R
F145Q
F145Q
R130H
R130H
K164E
K164E
L146R
L146R
H123N
H123N
D115C
D115C
K164K|G165-
K164K|G165-
L152P
L152P
I135Y
I135Y
I122P
I122P
H141Q
H141Q
G129I
G129I
A148T
A148T
A126fs
A126fs
T167S
T167S
E114Y
E114Y
D162V
D162V
D153N
D153N
I168F
I168F
R130W
R130W
K147H
K147H
I122I
I122I
D153A
D153A
C136F
C136F
G127K
G127K
L140R
L140R
Y155G
Y155G
L112*
L112*
D116I
D116I
T167E
T167E
L112V
L112V
L146S
L146S
E157W
E157W
K164fs
K164fs
L139I
L139I
G129W
G129W
R159fs
R159fs
A126S
A126S
S170M
S170M
G156G
G156G
R161C
R161C
A126G
A126G
D116K
D116K
H123R|C124-
H123R|C124-
G156fs
G156fs
K125N
K125N
Q149V
Q149V
H118E
H118E
L139T
L139T
Q171R|R172-
Q171R|R172-
K128E
K128E
F154S
F154S
R142F
R142F
G143Y
G143Y
C124G
C124G
E150D|A151-
E150D|A151-
G156A
G156A
G156-
G156-
F145P
F145P
K163M
K163M
R172R
R172R
Q171R
Q171R
A137V
A137V
A148fs
A148fs
S170T
S170T
C124S
C124S
R159T|T160-
R159T|T160-
R234fs
R234fs
G132V
G132V
I168V
I168V
V166W
V166W
K128-
K128-
I135V
I135V
V133S
V133S
A137R
A137R
A148M
A148M
K128R
K128R
T131*
T131*
A126M
A126M
A120G
A120G
A121V
A121V
L146M
L146M
H123R
H123R
E114H
E114H
H141Q|R142-
H141Q|R142-
I168A
I168A
K164L
K164L
A151fs
A151fs
A120K
A120K
M134L
M134L
G156H
G156H
V158A
V158A
D115F
D115F
R159Q
R159Q
S170F
S170F
A126V
A126V
L152A
L152A
Y155W|G156-
Y155W|G156-
L112L|S113-
L112L|S113-
P169E
P169E
L112F
L112F
K125P
K125P
P169V
P169V
L112L
L112L
E150Y
E150Y
G129V
G129V
V119S
V119S
K144I
K144I
P169S
P169S
L152D
L152D
K128F
K128F
R142V
R142V
E157T
E157T
I168Y
I168Y
Q171D
Q171D
D115I
D115I
K147K|A148-
K147K|A148-
V158Y
V158Y
K144E
K144E
E114P
E114P
E157F
E157F
V158I
V158I
H118M
H118M
G127P
G127P
T167P
T167P
G143*
G143*
D162W
D162W
A151G
A151G
T167I
T167I
N117Y
N117Y
D116Y
D116Y
L152L
L152L
G132P
G132P
D153Q
D153Q
S113I
S113I
I168H
I168H
G132E
G132E
Q149I
Q149I
K128L
K128L
Y138V
Y138V
Q149F
Q149F
V166F
V166F
C124-
C124-
E114R
E114R
G165E
G165E
C124R
C124R
T167N
T167N
H123D
H123D
G127G|K128-
G127G|K128-
E150I
E150I
A120N
A120N
V133C
V133C
P169R
P169R
E114Q
E114Q
A148D
A148D
P169P
P169P
C136W
C136W
E114D
E114D
G132Y
G132Y
R172S|R173-
R172S|R173-
T131S|G132-
T131S|G132-
A151W
A151W
G156M
G156M
L139E
L139E
G143G|K144-
G143G|K144-
K147*
K147*
G132R
G132R
R172A
R172A
H118Q
H118Q
H123V
H123V
W111fs
W111fs
A151D
A151D
F145S
F145S
R172L
R172L
I122N
I122N
C124I
C124I
Y155E
Y155E
Q149A
Q149A
K128N
K128N
R161M
R161M
L140Q
L140Q
L152H
L152H
H141W
H141W
G127R
G127R
D162fs
D162fs
C136Y
C136Y
G143P
G143P
C136V
C136V
A120P
A120P
R130S
R130S
A148R
A148R
F154F|Y155-
F154F|Y155-
G129-
G129-
K125L
K125L
D162C
D162C
T348fs
T348fs
K164W
K164W
G165S
G165S
G156R
G156R
G127S
G127S
A120F
A120F
K144P
K144P
K144N|F145-
K144N|F145-
R130-
R130-
H61fs
H61fs
C124T
C124T
L112A
L112A
Y138N
Y138N
K164I
K164I
V158M
V158M
T167F
T167F
D115N
D115N
L112K
L112K
M134Q
M134Q
M134C
M134C
R161Y
R161Y
F154T
F154T
F145L|L146-
F145L|L146-
T167Y
T167Y
C124*
C124*
R142S
R142S
F145fs
F145fs
K144C
K144C
G156W
G156W
D153H
D153H
T131Q
T131Q
C124H
C124H
T160D
T160D
G127fs
G127fs
V133T
V133T
R161N|D162-
R161N|D162-
Q149G
Q149G
R142R
R142R
Q171S
Q171S
G132V|V133-
G132V|V133-
A121A
A121A
I122L
I122L
M134R
M134R
R142I
R142I
R130E
R130E
S113R|E114-
S113R|E114-
G165*
G165*
I135W
I135W
A120D
A120D
R159-
R159-
C136G
C136G
Y155I
Y155I
A126F
A126F
D153*
D153*
A137E
A137E
Y155Y
Y155Y
G156N
G156N
H123W
H123W
D153C
D153C
D116H
D116H
A120E
A120E
A121W
A121W
A121K
A121K
H118W
H118W
F154R
F154R
D162P
D162P
V133*
V133*
R161P
R161P
D162*
D162*
L146W
L146W
Y138Q
Y138Q
L139F
L139F
V133L
V133L
T167M
T167M
L146A
L146A
A121G
A121G
H141-
H141-
D162K
D162K
C136fs
C136fs
C136R
C136R
G127A
G127A
G132C
G132C
K125A
K125A
D153fs
D153fs
D162N
D162N
L112Q
L112Q
R159Y
R159Y
G143H
G143H
D116F
D116F
G127L
G127L
E150*
E150*
V133H
V133H
A137G
A137G
V119W
V119W
D162G
D162G
A120Q
A120Q
G132F
G132F
F56fs
F56fs
L146F
L146F
H118N
H118N
A151Q
A151Q
V119R
V119R
A126Q
A126Q
D162H
D162H
H118V
H118V
K164D
K164D
Y155F
Y155F
C136E
C136E
F154P
F154P
K144K
K144K
K144I|F145-
K144I|F145-
V166R
V166R
I168C
I168C
C124C
C124C
G127C
G127C
V158N
V158N
D153I
D153I
S113fs
S113fs
I135F
I135F
V166Q
V166Q
S113Q
S113Q
R159L
R159L
A121I
A121I
P169R|S170-
P169R|S170-
E157M
E157M
V166C
V166C
I135R
I135R
A151E
A151E
H141S
H141S
R161A
R161A
R142M
R142M
K144T
K144T
Y138*|L139-
Y138*|L139-
N117I
N117I
G127T
G127T
K128I
K128I
Y174fs
Y174fs
A126D
A126D
L140L
L140L
A126L
A126L
T160R|R161-
T160R|R161-
F145T
F145T
Q171-
Q171-
K128K|G129-
K128K|G129-
R130Q
R130Q
R161T
R161T
F145E
F145E
R159G
R159G
F154K
F154K
E157H
E157H
A148Q
A148Q
K125K
K125K
Y155A
Y155A
V119T
V119T
A137C
A137C
H118-
H118-
D115D
D115D
R159A
R159A
L140K
L140K
P169*
P169*
A151A|L152-
A151A|L152-
T131W
T131W
K125Q
K125Q
G143V
G143V
V166-
V166-
M134H
M134H
K125T|A126-
K125T|A126-
I122K
I122K
K147R
K147R
K164A
K164A
K144V
K144V
A151*
A151*
K128C
K128C
V133W
V133W
E157P
E157P
L140I
L140I
T167*
T167*
E150D
E150D
L152Q
L152Q
R172Y
R172Y
A151H
A151H
A121S
A121S
K144W
K144W
R172C
R172C
C136*|A137-
C136*|A137-
K128V
K128V
S113H
S113H
T167G
T167G
K164S
K164S
L146D
L146D
S113Y
S113Y
I168D
I168D
K144-
K144-
L112Y
L112Y
P169-
P169-
D116D
D116D
L140T
L140T
S170-
S170-
A120R
A120R
K147G
K147G
V119I
V119I
G129G
G129G
T160P
T160P
S170K|Q171-
S170K|Q171-
A126C
A126C
R142G
R142G
K128T
K128T
L140fs
L140fs
Q171K
Q171K
I135E
I135E
L146V
L146V
I168E
I168E
Y155L
Y155L
A148Y
A148Y
I122fs
I122fs
I122M
I122M
V166*
V166*
E150L
E150L
I122N|H123-
I122N|H123-
Q149M
Q149M
Y155V
Y155V
C136S
C136S
D115D|D116-
D115D|D116-
H123C
H123C
Y155T
Y155T
Q171H
Q171H
D115R
D115R
L152G
L152G
F154Y
F154Y
C136M
C136M
H141R|R142-
H141R|R142-
Y138L|L139-
Y138L|L139-
I168N
I168N
Y138E
Y138E
H141E
H141E
R130L
R130L
D153L
D153L
K144S
K144S
P169P|S170-
P169P|S170-
Q149K
Q149K
L152I
L152I
E114M
E114M
C136H
C136H
L140F
L140F
G156P
G156P
F145Y
F145Y
D115S
D115S
E157V|V158-
E157V|V158-
D115E
D115E
F145G
F145G
L140V
L140V
K164Y
K164Y
E150N
E150N
Y155H
Y155H
N117K
N117K
L139W
L139W
A148G
A148G
K163K
K163K
Q149L
Q149L
F154*
F154*
G143R
G143R
V133V|M134-
V133V|M134-
F154M
F154M
A137P
A137P
A120Y
A120Y
S170E
S170E
V119Q
V119Q
F154E
F154E
V166I
V166I
D162T
D162T
G165-
G165-
G156L
G156L
R142W
R142W
T321fs
T321fs
I135C
I135C
V166G
V166G
C124E
C124E
L140-
L140-
A148S
A148S
K144fs
K144fs
C124K
C124K
K147W
K147W
G127D
G127D
L152W
L152W
K147D
K147D
F154fs
F154fs
H141F
H141F
K125H
K125H
L140P
L140P
L112M
L112M
V166L
V166L
L146*
L146*
S170W
S170W
G132S
G132S
G132T
G132T
N117P
N117P
V166P
V166P
G143M
G143M
K128W
K128W
S113F
S113F
G143N
G143N
V119N
V119N
K164N
K164N
A137H
A137H
S113D
S113D
K144N
K144N
K128A
K128A
I122S
I122S
H123H|C124-
H123H|C124-
F145M
F145M
K163Y
K163Y
I122C
I122C
A151K
A151K
K128D
K128D
N117E
N117E
S113P
S113P
T131I
T131I
R159M
R159M
F154W
F154W
V119V
V119V
K144Q
K144Q
A137A
A137A
I122T
I122T
K147T
K147T
G132A
G132A
K144D
K144D
M134T
M134T
R130N
R130N
S170G
S170G
H141R
H141R
E157E
E157E
G143fs
G143fs
F145V
F145V
K147S
K147S
K147L
K147L
Q149T
Q149T
I135N
I135N
R130R
R130R
L140*
L140*
G165I
G165I
E157D
E157D
Q171T
Q171T
R130D
R130D
E150K
E150K
R159S
R159S
K128K
K128K
I168L
I168L
R142R|G143-
R142R|G143-
G132-
G132-
G165N
G165N
V158G|R159-
V158G|R159-
I135I|C136-
I135I|C136-
E114E
E114E
L112D
L112D
R142E
R142E
H118K
H118K
R130Y
R130Y
S170P
S170P
L140G
L140G
S170R|Q171-
S170R|Q171-
D116W
D116W
D116G
D116G
Q149Q
Q149Q
D162E|K163-
D162E|K163-
G156C
G156C
D162D
D162D
D153Y
D153Y
G129Q
G129Q
R172G
R172G
K164P
K164P
K164G
K164G
L152fs
L152fs
R159H
R159H
E288fs
E288fs
V158T
V158T
D162S
D162S
S170V
S170V
T131R
T131R
K163A
K163A
M134N
M134N
D116C
D116C
L140C
L140C
I168T|P169-
I168T|P169-
E157fs
E157fs
N117A
N117A
Q171L
Q171L
D115L
D115L
Y138C
Y138C
H123Q
H123Q
F154C
F154C
P169H
P169H
T160C
T160C
H118G
H118G
F145C
F145C
L139K
L139K
I122-
I122-
T160F
T160F
R172V
R172V
M134-
M134-
S170N
S170N
L112N
L112N
K147Y
K147Y
T160A
T160A
V119A
V119A
Q171I
Q171I
V158E
V158E
E157C
E157C
C136*
C136*
G165H
G165H
A120fs
A120fs
E157A
E157A
V119L
V119L
R159V
R159V
L112fs
L112fs
L152S
L152S
Y155M
Y155M
Q171W
Q171W
R172S
R172S
D116D|N117-
D116D|N117-
A137I
A137I
A120L
A120L
E114D|D115-
E114D|D115-
V133P
V133P
H141fs
H141fs
R142*
R142*
N117T
N117T
G156E|E157-
G156E|E157-
K147T|A148-
K147T|A148-
F145A
F145A
E150V
E150V
L146Y
L146Y
Q171Q
Q171Q
G127W
G127W
K164R
K164R
K147C
K147C
K144L
K144L
G143T
G143T
R172N
R172N
G132I
G132I
R172*
R172*
D162I
D162I
E114G
E114G
P169Q
P169Q
A137D
A137D
E150fs
E150fs
E157K
E157K
P169F
P169F
H123E
H123E
P169W
P169W
V158G
V158G
H118F
H118F
R161fs
R161fs
L140E
L140E
Q149N
Q149N
Y155Q
Y155Q
M134A
M134A
P169T
P169T
T131M
T131M
R142N
R142N
G156D
G156D
L139*
L139*
A151S
A151S
V133D
V133D
R161I
R161I
E157G
E157G
G143I
G143I
G132K
G132K
R161S|D162-
R161S|D162-
L152N
L152N
K128P
K128P
L139N
L139N
D115W
D115W
I135S
I135S
G165V|V166-
G165V|V166-
I135K
I135K
H141C
H141C
I122W
I122W
T167fs
T167fs
K163E
K163E
I135M
I135M
T131H
T131H
V133Q
V133Q
Y155*|G156-
Y155*|G156-
Y138G
Y138G
G156*
G156*
K164F
K164F
A137W
A137W
D116P
D116P
L146E
L146E
D116V
D116V
L265fs
L265fs
K164M
K164M
V119H
V119H
F154V
F154V
A151M
A151M
I168-
I168-
G127E
G127E
C136P
C136P
R159P
R159P
Q149S
Q149S
P169fs
P169fs
I122Y
I122Y
F154D
F154D
D162-
D162-
H123T
H123T
V133G
V133G
D162F
D162F
3nt Deletion
Cluster 8
Synonymous
Cluster 4
Nonsense
Cluster 2
Single Missense
Cluster 9
Cluster 6
Cluster 3
PHTS
ASD/DD
Somatic cancer
ClinVar: LP
Frameshift
Cluster 7
gnomAD controls
Cluster 1
Cluster 5
Cluster 10
ClinVar: P
ClinVar: LB
1.0
10.0
-6
-3
0
3
6
Log scale
Correlation Correlation DAPI mEGFP-PTEN
Per variant images
Variant Synonymous
Variant Frameshift